Electrically conductive lignin reinforced PAA/HA scaffolds with enhanced biological activity via polyelectrolyte multilayer coatings for tissue engineering applications DOI Creative Commons
Caitriona Winters, Mario Culebras, Maurice N. Collins

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 10, 2025

In this study, a layer-by-layer deposition of poly(L-lysine) and hyaluronic acid (HA) as polyelectrolyte multilayer (PEM) film on polyacrylic (PAA) /HA/ lignin (LIG) disc shaped scaffolds is presented to increase the biological activity for tissue engineering applications. These are electrically conductive via introduction poly(3,4-ethylene dioxythiophene):hyaluronic (PEDOT:HA) nanoparticles (NPs), with diameter 10 mm thickness 3-4 mm. The formation was confirmed through contact angle measurements, fluorescence microscopy scanning electron (SEM) imaging. It found that PEM layers had unexpected benefit increased compression strength decreased swelling tend reinforce struts whilst possibly interfering diffusion pathways. Importantly, results show statistically significant improved attachment proliferation L929 fibroblast cells surface scaffolds. Furthermore, effect varied PEDOT:HA NP addition assessed it concluded samples containing 1% (w/v) exhibited desirable balance between good mechanical characteristics, high conductivity, cell adhesion proliferation. novel composite offer future potential in biomedical applications such engineering, wound healing biosensors.

Language: Английский

Facile synthesis of conductive PVA/HA/PEDOT composite hydrogel for human motion monitoring DOI
Xinbo Ding, Honghui Xu, Yanmin Wang

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: 43, P. 111848 - 111848

Published: Feb. 1, 2025

Language: Английский

Citations

0
Electrically conductive lignin reinforced PAA/HA scaffolds with enhanced biological activity via polyelectrolyte multilayer coatings for tissue engineering applications DOI Creative Commons
Caitriona Winters, Mario Culebras, Maurice N. Collins

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 10, 2025

In this study, a layer-by-layer deposition of poly(L-lysine) and hyaluronic acid (HA) as polyelectrolyte multilayer (PEM) film on polyacrylic (PAA) /HA/ lignin (LIG) disc shaped scaffolds is presented to increase the biological activity for tissue engineering applications. These are electrically conductive via introduction poly(3,4-ethylene dioxythiophene):hyaluronic (PEDOT:HA) nanoparticles (NPs), with diameter 10 mm thickness 3-4 mm. The formation was confirmed through contact angle measurements, fluorescence microscopy scanning electron (SEM) imaging. It found that PEM layers had unexpected benefit increased compression strength decreased swelling tend reinforce struts whilst possibly interfering diffusion pathways. Importantly, results show statistically significant improved attachment proliferation L929 fibroblast cells surface scaffolds. Furthermore, effect varied PEDOT:HA NP addition assessed it concluded samples containing 1% (w/v) exhibited desirable balance between good mechanical characteristics, high conductivity, cell adhesion proliferation. novel composite offer future potential in biomedical applications such engineering, wound healing biosensors.

Language: Английский

Citations

0