From injury to repair: the therapeutic potential of induced pluripotent stem cells in heart failure

Regenerative medicine reports ., Journal Year: 2025, Volume and Issue: 2(1), P. 22 - 30

Published: March 1, 2025

Heart failure is a complex clinical syndrome characterized by the heart’s inability to pump sufficient blood meet body’s metabolic demands, resulting in symptoms such as dyspnea, fatigue, and fluid retention. Despite significant advances pharmacological treatments device therapies, prognosis for patients with advanced heart remains poor. This underscores urgent need innovative regenerative therapies aimed at restoring cardiac function improving quality of life suffering from this debilitating condition. article provides comprehensive overview pathophysiologic mechanisms underlying end-stage failure, which include myocardial systolic diastolic dysfunction, neuroendocrine activation, inflammation, oxidative stress. Collectively, these lead progressive deterioration structure function, culminating failure. The also examines differences between ischemic non-ischemic cardiomyopathies their implications treatment strategies prognosis. Furthermore, review explores application medicine focusing on its potential repair functional recovery. In field medicine, induced pluripotent stem cells derived cardiomyocytes are considered cutting-edge technologies repair. Induced can differentiate into cardiomyocytes, thereby offering new hope regeneration. However, current research faces several challenges, including maturity integration immunogenicity concerns, difficulties scaling up production applications. Additionally, ethical issues related cell technology, sourcing tumorigenic risks, must be carefully addressed. highlights technology treating while emphasizing complexities involved transitioning laboratory practice.

Language: Английский

Exploring additive manufacturing of elastomers in biomedical applications

Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Language: Английский

Advances in in vitro cultivation techniques for comprehensive analysis of human gut microbiome

Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108595 - 108595

Published: May 1, 2025

Language: Английский