Association of the Drug Burden Index (DBI) exposure with outcomes: A systematic review
Journal of the American Geriatrics Society,
Journal Year:
2023,
Volume and Issue:
72(2), P. 589 - 603
Published: Nov. 25, 2023
Abstract
Background
The
Drug
Burden
Index
(DBI)
measures
an
individual's
total
exposure
to
anticholinergic
and
sedative
medications.
This
systematic
review
aimed
investigate
the
association
of
DBI
with
clinical
prescribing
outcomes
in
observational
pharmaco‐epidemiological
studies,
effect
on
functional
pre‐clinical
models.
Methods
A
search
nine
electronic
databases,
citation
indexes
gray
literature
was
performed
(April
1,
2007–December
31,
2022).
Studies
that
reported
primary
data
or
conducted
any
setting
humans
aged
≥18
years
animals
were
included.
Quality
assessment
using
Joanna
Briggs
Institute
critical
appraisal
tools
Systematic
Review
Centre
for
Laboratory
animal
Experimentation
risk
bias
tool.
Results
Of
2382
studies
screened,
70
met
inclusion
criteria
(65
humans,
five
animals).
In
included
function
(
n
=
56),
cognition
20),
falls
14),
frailty
7),
mortality
9),
quality
life
8),
hospitalization
length
stay
5),
readmission
1),
other
15)
2).
higher
significantly
associated
increased
(11/14,
71%),
poorer
(31/56,
55%),
(11/20,
55%)
related
outcomes.
Narrative
synthesis
used
due
significant
heterogeneity
study
population,
setting,
type,
definition
DBI,
outcome
measures.
could
not
be
pooled
heterogeneity.
animals,
18),
2),
1).
a
caused
frailty.
Conclusions
may
decreased
cognition.
Higher
inconsistently
mortality,
stay,
frailty,
reduced
life.
Human
findings
respect
are
supported
by
preclinical
interventional
studies.
as
tool
identify
older
adults
at
harm.
Language: Английский
Setting of initiation and factors associated with antidepressant use on entry to long‐term care facilities
British Journal of Clinical Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
Aims
Antidepressant
use
increases
around
long‐term
care
facility
(LTCF)
entry,
and
initiation
during
hospitalizations
may
contribute
to
this.
This
study
characterized
the
setting
(i.e.,
community‐based,
hospital
or
LTCF)
where
antidepressants
were
initiated
determined
associated
resident
characteristics.
Methods
A
cross‐sectional
including
non‐Indigenous
individuals
aged
65–105
years
who
entered
LTCFs
in
two
Australian
states
2015–2019,
dispensed
an
antidepressant
within
2
months,
was
conducted.
Care
settings
(community‐based,
from
linked
LTCF
records,
≤30
days
before
entry.
Pharmaceutical
claims
after
entry
screened
determine
initiation.
Multivariate
multinomial
logistic
regression
estimated
adjusted
odds
ratios
(aORs)
95%
confidence
intervals
(95%
CIs)
for
characteristics
with
of
Results
included
34
525
residents
1046
LTCFs.
Overall,
27
160
(78.7%)
commenced
prior
2552
(7.4%)
4813
(13.9%)
Mirtazapine
constituted
44.8%
(
n
=
1143)
hospitals
39.5%
1902)
Residents
≥90
more
likely
start
compared
community‐based
(aOR
1.97,
CI
1.74–2.23).
recently
using
a
psychotropic
LTCF.
Conclusions
Individuals
receiving
transition
are
often
already
taking
Future
interventions
optimize
should
consider
setting,
recency
indication
initiation,
ongoing
monitoring
safety.
Language: Английский
Anticholinergic burden risk and prevalence of medications carrying anticholinergic properties in elderly cancer patients in Jordan
Saudi Pharmaceutical Journal,
Journal Year:
2023,
Volume and Issue:
31(9), P. 101710 - 101710
Published: July 27, 2023
Geriatric
cancer
patients
are
susceptible
to
adverse
drug
events
due
the
complexity
of
their
chemotherapy
regimens
and
collateral
treatments
for
comorbid
conditions.
Prescribing
medications
with
anticholinergic
burden
characteristics
can
complicate
condition,
leading
negative
impacts
on
health
outcomes
quality
life,
including
an
increase
in
event
frequency,
physical
cognitive
impairments.This
study
aims
examine
prevalence
prescribing
identify
cumulative
load
risk
associated
drugs
prescribed
elderly
patients.
Also,
predictors
that
might
lead
raised
these
patients.This
retrospective
cross-sectional
included
(age
≥
65)
diagnosed
admitted
adult
oncology
unit
at
King
Abdullah
University
Hospital
(KAUH)
Jordan
during
period
between
(January
1st,
2019,
January
2022).
The
medication
charts
420
were
evaluated
outcomes.Of
total
subjects,
females
represented
49.3%,
average
age
was
72.95
(SD
=
7.33).
A
354
(84.3%)
least
one
carrying
properties.
Median
3
(IQR
4).
Our
found
194
(46.2%)
a
high
(cumulative
score
3).
Metoclopramide,
furosemide,
tramadol
most
frequently
Alimentary
tract
action
commonly
encountered
items
our
population.Our
revealed
significantly
among
Nearly
half
developing
serious
effects
related
activity
from
administered.
Polypharmacy
strongly
increased
score.
Evidence-based
recommendations
utilizing
strategies
safer
alternatives
deprescribing
inappropriate
could
reduce
such
prescribing.
Language: Английский