Covid-19 vaccination and menstrual bleeding disturbances among women of fertile age: a Norwegian registry study

European Journal of Epidemiology, Journal Year: 2024, Volume and Issue: 39(10), P. 1127 - 1138

Published: Oct. 1, 2024

Abstract This study evaluated the relationship between Covid-19 vaccination and menstrual bleeding disturbances using a large national registry linkage including 666,467 women 20 40 years of age residing in Norway on January 1st, 2019. Information vaccination—BNT162b2 mRNA-1273 — was obtained from Norwegian registry. Diagnoses (absent/scanty, excessive, irregular/frequent menstruation, intermenstrual bleeding) general practitioner database. We examined new-onset Cox regression comparing vaccinated to unvaccinated women, where contributed follow-up time as until day vaccination. In addition, we conducted self-controlled case-series analysis, sensitivity analysis excluding all those who remained throughout pandemic, evaluate role unmeasured confounding. observed an increased risk several after against Covid-19, ranging adjusted HR (aHR) 1.18 (95% CI: 1.04, 1.33) for 1.29 1.23, 1.36) periods. However, estimates were fully attenuated when at end (aHRs 0.97 1.08). No differences identified according vaccine dose or type. Our case series confirmed no first vaccination, though there slightly 61 days with 2. conclusion, modestly appeared reflect confounding by never received vaccinations, associations did not remain compared before among ever women.

Language: Английский

Prevalence of menstrual alterations following COVID-19 vaccination: systematic review & meta-analysis

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 19, 2024

Language: Английский