Preliminary Evaluation of a Mindfulness Intervention Program in Women with Long COVID Dysautonomia Symptoms

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100963 - 100963

Published: Feb. 1, 2025

The symptom burden for patients with Long COVID-associated dysautonomia is high, yet there are currently no effective treatments. Mindfulness programs reduce psychological and physical symptoms as well inflammatory gene expression in a variety of medical conditions. study aim was to evaluate the effect six-week mindfulness program women COVID symptoms. Using single arm, pre- posttest design, aged 18-54 years orthostatic intolerance suggestive were recruited from center. Participants attended standardized, six-week, virtual program. An active stand test 6-min walk (6MWT) performed at baseline post-intervention. Self-reported measures mental health collected baseline, post-intervention 4 week follow up included composite autonomic score (COMPASS-31), perceived stress (PSS), anxiety (GAD7), depression (PHQ8), COVID-19 event specific distress (IES-R), fatigue (FSI), sleep (ISI), well-being (MHC-SF), resilience (CD-RISC 10), quality life (SF-20). effects on conserved transcriptional response adversity (CTRA) examined by next-generation sequencing dried whole blood samples. Twenty participants enrolled mean age 39.9 (range 21-52 years). No significant changes observed or 6MWT. A reduction insomnia severity (ISI: 16.6 vs. 13.6; p = 0.001) post-intervention, but scores reverted toward levels 4-week follow-up. improvements seen symptoms, anxiety, stress, depression, well-being, related distress. Pro-inflammatory CTRA decreased significantly pre-to (p 0.004). Declines most among those 3 positive events 0.01), followed 2 0.04) 1 0.05). did not vary function recent illness, hospitalization, demographic characteristics, general history. virtual, may improve dysautonomia. While objective improvement observed, our findings suggest favorable intervention antiviral biology decrease expression. Nonetheless, this population very more attention needed provide multi-modal clinical therapies population.

Language: Английский

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Language Matters: What Not to Say to Patients with Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, and Other Complex Chronic Disorders

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(2), P. 275 - 275

Published: Feb. 13, 2025

People with Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and other complex chronic disorders consistently report having difficulty obtaining effective compassionate medical care being disbelieved, judged, gaslighted, even dismissed by healthcare professionals. We believe that these adversarial interactions language are more likely to arise when professionals confronting illnesses without proper training, diagnostic biomarkers, or FDA-approved therapies. These problematic conversations between practitioners patients often involve specific words phrases-termed the "never-words"-can leave in significant emotional distress negatively impact clinician-patient relationship recovery. Seeking prevent destructive interactions, we review key literature on best practices for difficult clinical discuss application of people ME/CFS, dysautonomia, disorders. provide recommendations alternative, preferred phrasing never-words, which can enhance therapeutic illness patient via compassionate, encouraging, non-judgmental language.

Language: Английский

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Identification of a multi-omics factor predictive of long COVID in the IMPACC study

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Following SARS-CoV-2 infection, ∼10-35% of COVID-19 patients experience long COVID (LC), in which often debilitating symptoms persist for at least three months. Elucidating the biologic underpinnings LC could identify therapeutic opportunities. We utilized machine learning methods on analytes and patient reported outcome surveys provided over 12 months after hospital discharge from >500 hospitalized IMPACC cohort to a multi-omics "recovery factor". participants who experienced had lower recovery factor scores compared without LC. Biologic characterization revealed increased levels plasma proteins associated with inflammation, elevated transcriptional signatures heme metabolism, decreased androgenic steroids patients. The was also altered circulating immune cell frequencies. Notably, were predictive occurrence as early admission, irrespective acute disease severity. Thus, identifies risk infection reveals biomarkers potential treatment targets.

Language: Английский

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Autonomic dysfunction in long COVID patients: a review

Bulletin of Rehabilitation Medicine, Journal Year: 2025, Volume and Issue: 24(1), P. 103 - 111

Published: Feb. 25, 2025

INTRODUCTION. The new coronavirus infection COVID-19 has had a significant impact on the health of populations around world, causing not only respiratory symptoms, but also wide range systemic disorders, including autonomic dysfunction. nervous system plays key role in regulating vital body functions such as heart rate, blood pressure, respiration and metabolism. Disorders can lead to serious consequences, chronic fatigue, orthostatic hypotension, tachycardia other symptoms that markedly impair quality life patients. AIM. To analyze available scientific data dysfunction long COVID patients, its possible pathophysiological mechanisms development potential methods correction. MATERIALS AND METHODS. We have searched for full-text publications Russian English over past four years eLIBRARY.RU, PubMed, Web Science databases using keywords: dysfunction, SARS-CoV-2, insufficiency, COVID-19, COVID. RESULTS DISCUSSION. review examines detail clinical manifestations approaches correction are considered. date, many been identified CONCLUSION. analyzed studies indicate presence causal relationship between However, it is necessary further study pathophysiology characteristics spectrum associated with infection, understand natural course, optimize treatment rehabilitation measures based personalized approach.

Language: Английский

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A Post-Pandemic Enigma: The Cardiovascular Impact of Post-Acute Sequelae of SARS-CoV-2

Circulation Research, Journal Year: 2023, Volume and Issue: 132(10), P. 1358 - 1373

Published: May 11, 2023

COVID-19 has become the first modern-day pandemic of historic proportion, affecting >600 million individuals worldwide and causing >6.5 deaths. While acute infection had devastating consequences, postacute sequelae SARS-CoV-2 appears to be a its own, impacting up one-third survivors often symptoms suggestive cardiovascular phenomena. This review will highlight suspected pathophysiology SARS-CoV-2, influence on system, potential treatment strategies.

Language: Английский

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