Janus Dual Self‐Strengthening Structure of Bi₂O₃/Gd₂O₃ Nanofibrous Membranes for Superior X‐Ray Shielding

Small, Journal Year: 2023, Volume and Issue: 19(40)

Published: June 1, 2023

Bi2 O3 /rare earth oxide biphasic absorbers are attractive for high-efficiency X-ray shielding due to the complementary absorption effects. However, its application is severely hindered by poor interphasic contact. Here, a new Janus interface engineering strategy reported construction of continuous and flexible /Gd2 crystal nanofibrous membranes (FJNMs) with micro/nano dual self-strengthening adhesion. This facilitates online micro-interlocking between nanofibers in situ nano-grain fusion crystals, significantly enhancing adhesive strength at interface. Additionally, synergistic effect from multiple reflections Gd2 lattices make superior radiation barrier. The FJNMs demonstrate integrated features exceptional efficiency (91%-100%), robust interfacial adhesion (lap-shear >3.8 MPa), prominent flexibility, lightweight, outstanding breathability. design concepts fibrosing absorber assemblies pave way asymmetrically assembling materials, setting stage fundamental shift next-generation materials.

Language: Английский

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Smart Responsive and Controlled-Release Hydrogels for Chronic Wound Treatment

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(12), P. 2735 - 2735

Published: Dec. 6, 2023

Chronic wounds are a major health challenge that require new treatment strategies. Hydrogels promising drug delivery systems for chronic wound healing because of their biocompatibility, hydration, and flexibility. However, conventional hydrogels cannot adapt to the dynamic complex environment, which involves low pH, high levels reactive oxygen species, specific enzyme expression. Therefore, smart responsive can sense respond these stimuli needed. Crucially, modulate release eliminate pathological factors by changing properties or structures in response internal external stimuli, such as enzymes, light, electricity. These also be used trigger antibacterial responses, angiogenesis, cell proliferation enhance healing. In this review, we introduce synthesis principles hydrogels, describe design applications healing, discuss future development directions. We hope review will inspire

Language: Английский

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Interfacial blending in co-axially electrospun polymer core-shell fibers and their interaction with cells via focal adhesion point analysis

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 237, P. 113864 - 113864

Published: March 20, 2024

Language: Английский

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Adhesive Antibacterial Moisturizing Nanostructured Skin Patch for Sustainable Development of Atopic Dermatitis Treatment in Humans

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(25), P. 32128 - 32146

Published: June 14, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin disease with complex etiology that lacks effective treatment. The therapeutic goals include alleviating symptoms, such as moisturizing and applying antibacterial anti-inflammatory medications. Hence, there an urgent need to develop patch effectively alleviates most of the AD symptoms. In this study, we employed "green" cross-linking approach poly(vinyl alcohol) (PVA) using glycerol, combined it polyacrylonitrile (PAN) fabricate core–shell (CS) nanofibers through electrospinning. Our designed structure offers multiple benefits core ensures controlled drug release increases strength patch, while shell provides moisturization exudate absorption. efficient PVA method facilitates inclusion sensitive molecules fermented oils. vitro studies demonstrate patches' exceptional biocompatibility efficacy in minimizing cell ingrowth into CS containing argan oil, property highly desirable for easy removal patch. Histological examinations conducted on ex vivo model showed nonirritant properties developed patches. Furthermore, eradication Staphylococcus aureus bacteria confirms potential use loaded oil or norfloxacin, separately, infected wounds. application patients, including one AD, demonstrated ideal effect. This innovative shows significant promise enhancing life quality sufferers by improving hydration avoiding infections.

Language: Английский

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Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1017 - 1017

Published: July 31, 2024

Over the last decade, scientists have shifted their focus to development of smart carriers for delivery chemotherapeutics in order overcome problems associated with traditional chemotherapy, such as poor aqueous solubility and bioavailability, low selectivity targeting specificity, off-target drug side effects, damage surrounding healthy tissues. Nanofiber-based systems recently emerged a promising system cancer therapy owing unique structural functional properties, including tunable interconnected porosity, high surface-to-volume ratio entrapment efficiency loading capacity, mass transport which allow controlled targeted delivery. In addition, they are biocompatible, biodegradable, capable surface functionalization, allowing target-specific release. One most common fiber production methods is electrospinning, even though relatively two-dimensional (2D) tightly packed structures rates limited its performance. Forcespinning an alternative spinning technology that generates high-throughput, continuous polymeric nanofibers 3D structures. Unlike forcespinning fibers by centrifugal forces rather than electrostatic forces, resulting significantly higher production. The functionalization nanocarriers on can result anticancer capabilities be activated external stimuli, light. This review addresses current trends potential applications light-responsive dual-stimuli-responsive electro- forcespun therapy, particular emphasis functionalizing nanofiber surfaces developing nano-in-nanofiber emerging dual-controlled release high-precision tumor targeting. progress prospective diagnostic therapeutic discussed context combination therapy.

Language: Английский

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NIR‐Light Activable 3D Printed Platform Nanoarchitectured with Electrospun Plasmonic Filaments for On Demand Treatment of Infected Wounds

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Bacterial infections can lead to severe complications that adversely affect wound healing. Thus, the development of effective dressings has become a major focus in biomedical field, as current solutions remain insufficient for treating complex, particularly chronic wounds. Designing an optimal environment healing and tissue regeneration is essential. This study aims optimize multi-functional 3D printed hydrogel infected A dexamethasone (DMX)-loaded electrospun mat, incorporated with gold nanorods (AuNRs), structured into short filaments (SFs). The SFs are gelatine methacrylate (GelMA) sodium alginate (SA) scaffold. photo-responsive AuNRs within significantly enhanced DXM release when exposed near-infrared (NIR) light. material exhibits excellent photothermal properties, biocompatibility, antibacterial activity under NIR irradiation, effectively eliminating Staphylococcus aureus Escherichia coli vitro. In vivo, combined light treatment facilitate infectes healing, killing S. bacteria, reduced inflammation, induced vascularization. final materials' shape be adjusted skin defect, anti-inflammatory on-demand, provide antimicrobial protection, accelerate

Language: Английский

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Magnetic two-dimensional nanocomposites for multimodal antitumor therapy: a recent review

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(6), P. 1404 - 1428

Published: Jan. 1, 2024

Magnetic 2D nanocomposites exhibit advanced antitumor applications, including magnetically targeted hyperthermia, drug delivery, phototherapy, nanozyme therapy, immunotherapy and multimodal imaging.

Language: Английский

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Solar‐to‐NIR Light Activable PHBV/ICG Nanofiber‐Based Face Masks with On‐Demand Combined Photothermal and Photodynamic Antibacterial Properties

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Hierarchical nanostructures fabricate by electrospinning in combination with light‐responsive agents offer promising scenarios for developing novel activable antibacterial interfaces. This study introduces an innovative face mask developed from poly(3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHBV) nanofibers integrated indocyanine green (ICG), targeting the urgent need effective antimicrobial protection community health workers. The research focuses on fabricating and characterizing this nanofibrous material, evaluating mask's mechanical chemical properties, investigating its particle filtration, assessing efficacy under photothermal conditions reactive oxygen species (ROS) generation. PHBV/ICG are produced using process, construct's morphology, structure, response investigated. of is tested, substantial bacterial inactivation both near‐infrared (NIR) solar irradiation demonstrated due to nanofibers. material's further analyzed cyclic simulate real‐world conditions, confirming durability consistency. highlights synergistic impact PHBV ICG enhancing activity, presenting a biocompatible environmentally friendly solution. These findings path masks that contribute significantly field materials solve critical public challenges.

Language: Английский

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Stimuli‐Responsive Core‐Shell Electrospun Nanofibers for Drug Delivery: A Mini‐Review

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

ABSTRACT Core‐shell nanofibers have the potential to surpass traditional monolithic electrospun in drug delivery, due their ability encapsulate sensitive therapeutics within core, protect them from degradation, and enable controlled release profiles through shell. When designed be stimuli‐responsive, these evolve “smart” delivery platforms for advanced therapeutic applications. This mini‐review examines recent advancements fabrication applications of stimuli‐responsive core‐shell nanofibers. Key techniques, such as coaxial electrospinning, single‐nozzle electrospinning using water‐in‐oil or oil‐in‐water emulsions immiscible blends (e.g., polyethylene oxide chitosan; polyvinylpyrrolidone polyvinylidene), needleless post‐fabrication coating methods, are discussed along with respective advantages limitations. Additionally, review also explores how can engineered respond stimuli like near‐infrared (NIR) light, ultrasound, temperature, pH changes. Representative examples illustrate reduce initial burst release, on‐demand chemodrug implement photothermal therapy against cancer cells. At end, we offer perspectives on challenges, opportunities, new directions future development.

Language: Английский

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Gold Nanostar‐Decorated Electrospun Nanofibers Enable On‐Demand Drug Delivery

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract This study explores the development of a photo‐responsive bicomponent electrospun platform and its drug delivery capabilities. is composed two polymers poly(lactide‐ co ‐glycolide) (PLGA) poly(3‐hydroxybutyrate‐ ‐3‐hydroxyvalerate) (PHBV). Then, decorated with plasmonic gold nanostars (Au NSs) that are capable on‐demand release. Using Rhodamine‐B (RhB) as model drug, release behavior bi‐polymer system compared versus homopolymer fibers. The RhB incorporated in PHBV part platform, which provides more sustained release, both absence presence near‐infrared (NIR) irradiation. Under NIR exposure, thermal imaging reveals notable increase surface temperature, facilitating enhanced Furthermore, demonstrates upon multiple irradiation cycles. offers promising approach for stimuli‐responsive delivery, making it strong candidate therapy applications.

Language: Английский

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