Field Enhancement Tuning through Subnanoscale Polymer Encapsulation of Gold–Silver Alloy Plasmon Nanoparticles for SERS Applications

ACS Applied Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

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In vitro anticancer activity of melanin-like nanoparticles for multimodal therapy of glioblastoma

Nanotechnology Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract Glioblastoma (GBM) is one of the most aggressive and hard to treat cancers. Traditional anti-cancer treatment methods have low efficiency lifespan after diagnosis only 12–18 months. Brain tumor cells overexpress many proteins that play an important role in progression can be used as therapeutic targets. One promising approaches cancer down-regulation extracellular matrix glycoprotein – Tenascin-C (TN-C) through RNA interference therapy. However, effective delivery double stranded with strand complementary TN-C mRNA sequence difficult due rapid degradation by nucleases intracellular uptake. Polydopamine (PDA), a biomimetic polymer characterized high biocompatibility simple modification ability, commonly nanobiomedicine create drug/gene vehicle. Furthermore, photothermal characteristics this enable its application therapy (PTT), which great option for treatment. Here we synthesize PDA nanoparticles (NPs) coated polyamidoamine dendrimers generation 3.0 (DD3.0) anti-TN-C doxorubicin delivery. As prepared [email protected] NPs are then combined drug delivery, gene silencing, PTT GBM. The obtained materials analyzed terms physicochemical properties well their cytotoxicity, using human GBM cells. results demonstrate nanocarriers non-viral vehicle approach killing glioma via chemo-PTT (CT-PTT). contributed 3-fold reduction proliferation rate cells, decrease level expression (by 30%) number viable up 20%.

Language: Английский

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Three‐phase bio‐nanocomposite natural‐rubber‐based microfibers reinforced with cellulose nanowhiskers and 45S5 bioglass obtained by solution blow spinning

Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 140(45)

Published: Sept. 5, 2023

Abstract Aiming at biomedical applications, the present work developed a new bio‐nanocomposite fibrous mat based on natural rubber (NR) reinforced with 45S5 bioglass particles (BG) and cellulose nanowhiskers (CNW), which reveals excellent mechanical properties, good biocompatibility bioactivity properties. Analyses of specimens were conducted by means morphological observations (SEM) thermal analysis (TG/DTG), as well tests used to verify effect incorporation BG CNW ultimate properties these flexible NR‐CWN/BG membranes. An SEM revealed that all filaments possessed ribbon‐like morphology, increasing diameters concentration increased. This likely results from an increased viscosity solution for fiber blowing. In comparison neat NR mats, bio‐nanocomposites significantly improved due presence dispersed in matrix. According TG/DTG analysis, specimens' stability was unaffected high content, profiles similar, isoprene chains decomposition occurring between 350 450°C. In‐vitro fibroblasts confirmed mats are noncytotoxic. It found enhanced cellular growth hold great promise tissue engineering applications.

Language: Английский

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Heat-conducting elastic ultrafine fiber sponges with boron nitride networks for noise reduction

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 649, P. 1023 - 1030

Published: June 8, 2023

Language: Английский

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Biomedical Applications of Nanomaterials

Courses and lectures, Journal Year: 2024, Volume and Issue: unknown, P. 139 - 209

Published: Jan. 1, 2024

Language: Английский

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