Transcriptomic era of cancers in females: new epigenetic perspectives and therapeutic prospects DOI Creative Commons

Runhe Zhu,

Jiawei Ni,

Jiangshan Ren

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 13, 2024

In the era of transcriptomics, role epigenetics in study cancers females has gained increasing recognition. This article explores impact epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNA, on females, including breast, cervical, ovarian ( 1 ). Our findings suggest that these markers not only influence tumor onset, progression, metastasis but also present novel targets for therapeutic intervention. Detailed analyses methylation patterns have revealed aberrant events cancer cells, particularly promoter region hypermethylation, which may lead to silencing suppressor genes. Furthermore, we examined complex roles modifications long RNAs regulating expression cancer-related genes, thereby providing a scientific basis developing targeted therapies. research emphasizes importance understanding functions mechanisms develop effective treatment strategies. Future approaches include drugs targeting specific markers, could improve outcomes enhance patient survival quality life. Through efforts, aim offer new perspectives hope prevention, diagnosis, females.

Language: Английский

Effectiveness of Pelvic Floor Muscle and Education-based Therapies on Bladder, Bowel, Vaginal, Sexual, Psychological Function, Quality of Life, and Pelvic Floor Muscle Function in Females Treated for Breast Cancer: A Systematic Review DOI Creative Commons
Marie‐Pierre Cyr, Tamara L. Jones, Udari N. Colombage

et al.

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Purpose of review Breast malignancy is the most common cancer in females. Symptoms pelvic floor disorders and sexual dysfunction secondary to systemic treatment may occur. Non-surgical, non-pharmaceutical conservative therapies, namely muscle (PFM) education-based could be beneficial reduce these symptoms this population. This systematic aimed examine evidence regarding their effectiveness on bladder, bowel, vaginal, sexual, psychological function, quality life, PFM function breast populations. Recent findings Six databases were searched identify interventional studies effect or combined (multimodal) therapies any outcome interest. The search yielded 603 results, from which 12 included. Of these, six (50%) RCTs, one (8%) was a non-RCT with two groups, five (42%) non-RCTs single group. Findings suggest that (active) beneficial, education format CBT improve bladder function. No data found for bowel results RCTs inconclusive draw conclusions vaginal Sexual frequently reported outcome. (active > passive) more likely than not For + unlikely although physical exercise provide further improvement. ± Given limited number methodological limitations, caution should exercised when interpreting study results. More research needed confirm investigate clinical value combined, multimodal Summary helpful Clinicians consider highest level available guide practice use judgement select components appropriate dosages.

Language: Английский

Citations

0
Cancer and Stress: Understanding the Connections and Interventions DOI
Stacy D. D’Andre,

Lauretta J. Ellsworth,

Janae L. Kirsch

et al.

American Journal of Lifestyle Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Stress is ubiquitous in our modern society and contributes to many disease states. This narrative review describes the effect of stress/distress on cancer development progression. Seminal randomized controlled trials, systematic reviews/meta-analyses, distress management guidelines from National Comprehensive Cancer Network (NCCN), American Society Clinical Oncology (ASCO), for Integrative LinearOncology (SIO) are highlighted. We describe physiological effects distress, assessment, management. Psychological treatments summarized. Evidence-based lifestyle modifications integrative therapies reviewed detail, including mindfulness-based techniques, yoga, guided imagery, breathing hypnosis, exercise, music therapy, qigong/Tai Chi, eye movement desensitization reprocessing, improving sleep heart rate variability. Recognition treatment can improve quality life. More research needed determine managing outcomes, as well best type duration intervention, noting that benefits interventions may be specific patients with different types.

Language: Английский

Citations

2
Exercise interventions for self-perceived body image, self-esteem and self-efficacy in women diagnosed with breast cancer: a systematic review with meta-analysis and meta-regressions DOI Creative Commons
María Jesús Casuso-Holgado, Javier Martínez-Calderón, Patricia Martínez-Miranda

et al.

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(10)

Published: Sept. 17, 2024

Language: Английский

Citations

1
Transcriptomic era of cancers in females: new epigenetic perspectives and therapeutic prospects DOI Creative Commons

Runhe Zhu,

Jiawei Ni,

Jiangshan Ren

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 13, 2024

In the era of transcriptomics, role epigenetics in study cancers females has gained increasing recognition. This article explores impact epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNA, on females, including breast, cervical, ovarian ( 1 ). Our findings suggest that these markers not only influence tumor onset, progression, metastasis but also present novel targets for therapeutic intervention. Detailed analyses methylation patterns have revealed aberrant events cancer cells, particularly promoter region hypermethylation, which may lead to silencing suppressor genes. Furthermore, we examined complex roles modifications long RNAs regulating expression cancer-related genes, thereby providing a scientific basis developing targeted therapies. research emphasizes importance understanding functions mechanisms develop effective treatment strategies. Future approaches include drugs targeting specific markers, could improve outcomes enhance patient survival quality life. Through efforts, aim offer new perspectives hope prevention, diagnosis, females.

Language: Английский

Citations

1