The Hormetic Adaptative Capacity and Resilience to Oxidative Stress Is Strengthened by Exposome Enrichment with Air Cold Atmospheric Plasma: A Metabolome Targeted Follow-Up Approach DOI Creative Commons
Lucía González-Llorente, Miguel Ángel Andrés Gasco, Miguel Aranda

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 949 - 949

Published: April 12, 2025

Background/Objectives: The exposome, encompassing all environmental influences on health, plays a pivotal role in oxidative stress-related diseases. Negative air ions (NAIs), generated via cold atmospheric plasma (CAP), have been proposed as potential modulators of resilience. This study aims to investigate the metabolic adaptations induced by prolonged exposure an NAI-enriched environment mice, focusing its effects stress markers and energy metabolism liver blood. Methods: Twenty male C57BL/6J mice were divided into four groups: two experimental groups exposed Air Cold Atmospheric Plasma–Nanoparticle Removal (aCAP-NR) device for either 18 days (short-term, ST) or 28 (long-term, LT), control without exposure. Targeted metabolomics was performed whole blood using ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS). Statistical pathway analyses conducted assess alterations. Results: Metabolic profiling revealed significant shifts pathways, including enhanced glutathione metabolism, reduced lipid peroxidation, modulation purine metabolism. Short-term led increased mitochondrial efficiency homeostasis, while long-term adaptive reprogramming, with higher inosine levels suggesting antioxidant anti-inflammatory responses. No adverse systemic hepatic health observed. Conclusions: NAI aCAP-NR elicits hormetic response, enhancing resilience stress. These findings suggest that controlled enrichment NAIs may serve novel non-invasive strategy mitigating damage improving adaptative capacity stress, warranting further translational research.

Language: Английский

Plasma jets effectively promoting cloud condensation nuclei formation and aerosol activation in artificial weather modification DOI
Chuan Li, Tingyu Liang,

Zutao Wang

et al.

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(3)

Published: March 1, 2025

Enhancing precipitation is of paramount importance in water-scarce regions. The availability cloud condensation nuclei (CCN) a critical prerequisite for formation. This study investigates novel approach to promoting CCN formation by using plasma jets. results indicate that after 30 min jet operating, the concentration increases factor 1.1–2.6, while aerosol activation rate approximately 2.5 times. remains high even turned off, which attributed significant number electrons and ions generated jet, facilitating charging. main mechanisms driving are ion-ion recombination reduced free energy barrier during water vapor following These experimental findings demonstrate feasibility jets enhance CCN, with implications artificial weather modification, particularly context climate change.

Language: Английский

Citations

3
Special Issue: Plasma and Liquids—Fundamentals and Applications DOI Creative Commons
Stephan Reuter, Ahmad Hamdan

Plasma Processes and Polymers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Citations

0
The Hormetic Adaptative Capacity and Resilience to Oxidative Stress Is Strengthened by Exposome Enrichment with Air Cold Atmospheric Plasma: A Metabolome Targeted Follow-Up Approach DOI Creative Commons
Lucía González-Llorente, Miguel Ángel Andrés Gasco, Miguel Aranda

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 949 - 949

Published: April 12, 2025

Background/Objectives: The exposome, encompassing all environmental influences on health, plays a pivotal role in oxidative stress-related diseases. Negative air ions (NAIs), generated via cold atmospheric plasma (CAP), have been proposed as potential modulators of resilience. This study aims to investigate the metabolic adaptations induced by prolonged exposure an NAI-enriched environment mice, focusing its effects stress markers and energy metabolism liver blood. Methods: Twenty male C57BL/6J mice were divided into four groups: two experimental groups exposed Air Cold Atmospheric Plasma–Nanoparticle Removal (aCAP-NR) device for either 18 days (short-term, ST) or 28 (long-term, LT), control without exposure. Targeted metabolomics was performed whole blood using ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS). Statistical pathway analyses conducted assess alterations. Results: Metabolic profiling revealed significant shifts pathways, including enhanced glutathione metabolism, reduced lipid peroxidation, modulation purine metabolism. Short-term led increased mitochondrial efficiency homeostasis, while long-term adaptive reprogramming, with higher inosine levels suggesting antioxidant anti-inflammatory responses. No adverse systemic hepatic health observed. Conclusions: NAI aCAP-NR elicits hormetic response, enhancing resilience stress. These findings suggest that controlled enrichment NAIs may serve novel non-invasive strategy mitigating damage improving adaptative capacity stress, warranting further translational research.

Language: Английский

Citations

0