Nanocarriers in Skin Cancer Treatment: Emerging Drug Delivery Approaches and Innovations.

Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100068 - 100068

Published: Dec. 1, 2024

Language: Английский

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Poly(oligoethylene glycol methylether methacrylate-co-methyl methacrylate) Aggregates as Nanocarriers for Curcumin and Quercetin

Polymers, Journal Year: 2025, Volume and Issue: 17(5), P. 635 - 635

Published: Feb. 27, 2025

Amphiphilic statistical copolymers can be utilized for the formulation of nanocarriers drug delivery insoluble substances. Oligoethylene glycol methylether methacrylate and methyl are two biocompatible monomers that used biological applications. In this work, synthesis linear poly(oligoethylene methacrylate-co-methyl methacrylate), P(OEGMA-co-MMA), via reversible addition fragmentation chain transfer (RAFT) polymerization is reported. P(OEGMA-co-MMA) with different comonomer compositions were synthesized characterized by size exclusion chromatography (SEC), 1H-NMR, ATR-FTIR spectroscopy. Self-assembly studies carried out dissolution polymers in water co-solvent protocol. For characterization formed nanoaggregates, DLS, zeta potential, fluorescence spectroscopy (FS) experiments performed. Such measurements delineate association into aggregates structural characteristics dependent on copolymer composition. order to investigate encapsulation properties nanoparticles, curcumin quercetin loaded them. The protocol was followed varying concentrations drugs. Nanocarrier confirmed DLS while UV-Vis FS revealed loading optical drug-loaded nanosystems each case. maximum efficiency found 54% 49% quercetin. all nanocarriers, preliminary qualitive biocompatibility conducted FBS medium aqueous solutions which resulted no significant interactions between serum proteins. Novel fabricated as a first step utilization these nanomedicine.

Language: Английский

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Fabrication and Characterization of Curcumin and Piperine Loaded CMTG/rGO Electrospun for Breast Cancer Treatment

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 7, 2025

Language: Английский

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Oral Bioavailability Enhancement of Anti-Cancer Drugs Through Lipid Polymer Hybrid Nanoparticles

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 381 - 381

Published: March 17, 2025

Cancer is considered as the second leading cause of death worldwide. Chemotherapy, radiotherapy, immunotherapy, and targeted drug delivery are main treatment options for treating cancers. Chemotherapy drugs either available oral or parenteral use. Oral chemotherapy, also known chemotherapy at home, more likely to improve patient compliance convenience. anti-cancer have bioavailability issues associated with lower aqueous solubility, first-pass metabolism, poor intestinal permeability absorption, degradation throughout its journey in gastrointestinal tract. A highly developed carrier system lipid polymer hybrid nanoparticles (LPHNs) has been introduced. These nanocarriers enhance stability, reduce metabolism. Consequently, this will a positive impact on enhancement. This article provides an in-depth analysis LPHNs novel agents. It discusses overview limited drugs, their reasons consequences, based delivery, conventional modern preparation methods well loading entrapment efficiencies. In addition, gives insight into mechanistic approach enhancement, potential applications limitations, future prospects delivery.

Language: Английский

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Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Ginseng-Based Nanotherapeutics in Cancer Treatment: State-of-the-Art Progress, Tackling Gaps, and Translational Achievements

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 250 - 250

Published: April 3, 2025

Among medicinal plants, the Panax genus (family: Araliaceae) includes plant species widely recognized for their multi-faceted pharmacological attributes. The triterpenoids, designated as ginsenosides, are increasingly drug-like molecules in cancer therapies due to therapeutic role restricting tumor invasion, proliferation, metastasis, apoptosis, and drug resistance reversal cells. In nanobiotechnological era, nano-delivery systems provide feasible solutions address bottlenecks associated with traditional delivery methods (low bioavailability, instability gastrointestinal tract, high dosage requirements, side effects, poor absorption, incomplete utilization body). dedicated efforts precise effective treatment have directed development of ginsenoside-based achieve potent anticancer efficacies limitations ginseng pharmacokinetics, facilitating trials. Studies into pharmacokinetics showed a remarkable prolonged clearance free levels ~15% (ginsenoside RB1 nanoparticles) mice (compared only ~5% ginsenosides) better antitumor efficacies, demonstrating key success biotechnology development. Delving interventions ginseng-derived therapeutics, this study summarizes current advances achievements, particularly treatment, tackles existing gaps, focuses on solutions, examines prospects translational success.

Language: Английский

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Transformative potential of plant-based nanoparticles in cancer diagnosis and treatment: bridging traditional medicine and modern therapy

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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Potential of integrating phytochemicals with standard treatments for enhanced outcomes in TBI

Brain Injury, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 21, 2025

TBI's intricate pathophysiology, which includes oxidative stress, neuroinflammation, apoptosis, and mechanical injury, makes it a serious public health concern. Although stabilization secondary damage management are the main goals of current treatments, their efficacy is still restricted. The potential for improving patient outcomes by combining phytochemicals with traditional medicines examined in this review. study neuroprotective qualities ginsenosides, ginkgolides, resveratrol, curcumin as well antioxidant anti-inflammatory activities. Analysis was done on molecular pathways medication delivery techniques to improve translational drug availability clinical practice. Phytochemical substances directly influence TBI-related neurogenic functional restoration while also affecting subsequent neural processes. Particle-based medicine platforms enhance therapeutic efficacy, emerging innovative solutions targeted delivery. When medical therapies integrate phytochemicals, becomes possible achieve better results through enhanced synergy. This review uniquely integrates standard TBI emphasizing advanced strategies neuroprotection outcomes. Unlike previous studies, explores novel platforms, such nanoparticle-based systems, highlights synergy between conventional recovery.

Language: Английский

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Nano-Engineered Therapies for Breast Cancer

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 413 - 438

Published: April 25, 2025

The effectiveness of the conventional treatment strategies is falling, as tumors are gradually becoming chemoresistant. Breast cancer cells persistently overexposed to therapeutic agents, leading them develop multidrug resistance. Molecular mechanisms causing Multidrug Resistance (MDR) include overexpression drug efflux transporters, evasion apoptosis, activation NF-κB and other signaling pathways supporting tumor proliferation, dysregulation DNA repair mechanisms, epigenetic modulations tumor-supportive microenvironment. This present study explores biomedical applications nanoparticles combat resistance in breast cancer. We focus on that can bypass pumps, deliver agents precisely, co-deliver siRNA/miRNA for repair, release drugs responsively. Looking ahead, we identify future research opportunities multi-targeting pathways, hypoxia/enzyme-triggered release, genetic/epigenetic modulation, personalized medicines, AI-driven optimization nanoparticle properties. ‎

Language: Английский

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Improving the Biopharmaceutical Properties of Cannabinoids in Glioblastoma Multiforme Therapy With Nanotechnology: A Drug Delivery Perspective

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(8)

Published: Dec. 1, 2024

ABSTRACT Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor in adults and known for its rapid proliferation infiltrative nature. Current therapeutic strategies include surgical resection followed by radio‐ chemotherapy. Still, they are hindered GBM biological characteristics physical‐chemical properties of chemotherapeutic drugs, leading to limited efficacy poor prognosis. Cannabinoids have emerged as potential anti‐GBM agents, exhibiting antiangiogenic, antimetastatic, antiproliferative effects. However, their hydrophobicity oral bioavailability pose significant challenges clinical applications. This study evaluates nanocarriers enhancing solubility targeted delivery cannabinoids therapy. The innovative combination nanotechnology with cannabinoid‐based treatment offers a promising strategy improve outcomes. We addressed application deliver cannabinoids, which can enhance passage across blood‐brain barrier enable Studies demonstrate improving solubility, stability, controlled release highlighting advancements nanocarrier design optimized glioma cells. exert antitumor effect, including induction apoptosis through ceramide p8‐regulated pathways modulation immune responses. evidence found this supports nanotechnologies regimens patient

Language: Английский

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