Life Cycle, Journal Year: 2024, Volume and Issue: 4
Published: Nov. 22, 2024
Language: Английский
Pharmacology Research & Perspectives, Journal Year: 2024, Volume and Issue: 12(3)
Published: June 1, 2024
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2n first appeared in Wuhan, China 2019. Soon after, it was declared a pandemic World Health Organization. The health crisis imposed new virus and its rapid spread worldwide prompted fast development of vaccines. For time human history, two vaccines based on recombinant genetic material technology were approved for use. These mRNA applied massive immunization programs around world, followed other more traditional approaches. Even though all tested clinical trials prior to their general administration, serious adverse events, usually very low incidence, mostly identified after application millions doses. Establishing direct correlation (the cause-effect paradigm) between vaccination appearance effects has proven challenging. This review focuses main observed vaccination, including anaphylaxis, myocarditis, vaccine-induced thrombotic thrombocytopenia, Guillain-Barré syndrome, transverse myelitis reported context COVID-19 vaccination. We highlight symptoms, laboratory tests required an adequate diagnosis, briefly outline recommended treatments these effects. aim this work is increase awareness among healthcare personnel about events that may arise post-vaccination. Regardless ongoing discussion safety must be promptly treated effectively reduce risk complications.
Language: Английский
Citations
9
Deleted Journal, Journal Year: 2025, Volume and Issue: 22(1)
Published: Jan. 2, 2025
Abstract COVID-19 vaccines effectively reduce morbidity and mortality but are associated with Events Supposedly Attributable to Vaccination or Immunization (ESAVI). This cross-sectional study examined the incidence characteristics of ESAVI in Brazil during 2021, using data from e-SUS Notifica Vacivida. Among 109,424 reports, rates were 30.82 83.08 symptoms per 100,000 doses. Most reports involved women (70.83%), individuals aged 30–39, residents southern region. Common included headache, fever, myalgia. AstraZeneca accounted for 56.79% cases. Non-severe cases predominated (95.03%), 78.7% classified as “product-related according literature.” Mortality was rare (0.03%), a significant association identified between DNA deaths (χ 2 = 4.333; p 0.037; OR 2.673; 95% CI 1.020–7.007). Regional disparities evident, higher incidences South Southeast. Underreporting non-severe remains challenge. Logistic regression showed lower odds severe among adults Black/Brown individuals, while Pfizer initial doses linked odds. These results highlight safety emphasizing need strengthened post-vaccination surveillance address regional disparities, health inequities, vaccine hesitancy.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139395 - 139395
Published: Jan. 1, 2025
Language: Английский
Citations
0
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: Feb. 4, 2025
Language: Английский
Citations
0
International Journal of Vaccine Theory Practice and Research, Journal Year: 2024, Volume and Issue: 3(2), P. 1275 - 1344
Published: Aug. 16, 2024
The COVID-19 modified mRNA (modmRNA) lipid nanoparticle-based “vaccines” are not classical antigen-based vaccines but instead prodrugs informed by gene therapy technology. Of considerable note, these products have been linked to atypical adverse and serious event profiles. As discussed in Part 1, health-related risks drawbacks were drastically misreported underreported the Pfizer Moderna trial evaluations of genetic products. Now 2, we examine main structural functional aspects injectables. modmRNA injectable introduce a unique set biological challenges human body with potential induce an extensive range adverse, crippling, life-threatening effects. Based on fact that there is no current method quantify host (cell-based) spike protein production vivo following injection prodrugs, standard “dose”. This part due differences output, which depends cell metabolism transfection efficiency. It therefore difficult predict profiles individual basis, considering millions adults across world reported severe events context products, valid concerns raised regarding infants younger age groups for whom poses only minimal risks. We address process-related impurities inherent mass posed contaminants. then categorize principal associated brief systems-based synopsis each six domains harms: (1) cardiovascular, (2) neurological, (3) hematologic; (4) immunological, (5) oncological, (6) reproductive. conclude discussion primary public health regulatory issues arising from this evidence-informed synthesis literature reiterate urgency imposing global moratorium modmRNA-LNP-based platform.
Language: Английский
Citations
2
Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 1059 - 1059
Published: Sept. 17, 2024
Conventional vaccines rarely cause severe allergic reactions. However, the rapid development and approval of COVID-19 left limited initial data on their adverse reactions, particularly in individuals with a history allergy. The aim this study was to assess compare safety profile different doses brands subjects allergy vs. those without
Language: Английский
Citations
1
Pharmacology Research & Perspectives, Journal Year: 2024, Volume and Issue: 12(5)
Published: Sept. 12, 2024
Language: Английский
Citations
0
Medical Principles and Practice, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33
Published: Dec. 19, 2024
Although COVID-19 vaccines exhibit diverse side effects, taste and saliva secretory disorders have remained poorly understood despite their negative impact on the overall quality of life. The present study aimed to characterize oral adverse effects following vaccination assess similarities with symptoms in patients. A literature search was conducted databases, including PubMed, LitCovid, Google Scholar, retrieve relevant studies. narrative review indicated that a certain number vaccinated people develop ageusia, dysgeusia, hypogeusia, xerostomia, dry mouth, while they are rare compared symptoms. prevalence varies by country/region such geographical differences may be related type vaccine used. Similar SARS-CoV-2 infection, adversely affects perception salivary secretion females older subjects more frequently than males younger subjects. Their impairments mostly appear withing three days after vaccination, bitter is specifically impaired some cases. Considering share characteristics patients, it speculated spike protein derived from infection pathophysiologically responsible for disorders. This because has potential interact ACE2 expressed cells, produce proinflammatory cytokines, form antiphospholipid antibodies. Our results do not deny advantage but attention should paid post-vaccination addition
Language: Английский
Citations
0
Life Cycle, Journal Year: 2024, Volume and Issue: 4
Published: Nov. 22, 2024
Language: Английский
Citations
0