Vitamin D: A Nutraceutical Supplement at the Crossroad Between Respiratory Infections and COVID-19 DOI Open Access
Manuela Rizzi, Pier Paolo Sainaghi

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2550 - 2550

Published: March 12, 2025

Even though in mid-2023 the World Health Organization declared end of public health emergency international concern status for COVID-19, many areas uncertainty about SARS-CoV-2 infection pathophysiology remain. Although last 4 years pharmaceutical industries widely invested development effective antiviral treatments and vaccines, large disparities their availability worldwide still exist, thus fostering investigation nutritional supplements as adjuvant therapeutic approaches disease management, especially resource-limited settings. During COVID-19 pandemic, vitamin D has been used an over-the-counter solution to improve evolution, thanks its known immunomodulatory anti-inflammatory actions. Ecological observational studies support a relationship between hypovitaminosis negative outcomes and, according this evidence, several research groups investigated role supplementation protecting from and/or improving evolution. This narrative review is intended offer insights into existing data on D’s biological effects respiratory infections, COVID-19. Furthermore, it will also brief overview complex interplay vaccine-elicited immune response, with special attention anti-COVID-19 vaccines.

Language: Английский

Vitamin D in Orthopädie und Unfallchirurgie DOI

Stefan Karger,

Andreas Röth

Arthritis und Rheuma, Journal Year: 2025, Volume and Issue: 45(01), P. 09 - 20

Published: Feb. 1, 2025

Zusammenfassung Ziel der vorliegenden Arbeit ist es, das Verständnis Physiologie, des Stoffwechsels und biologischen Funktionen von Vitamin D zu vertiefen sowie Hinweise zur Identifizierung Risikopatienten schließlich Behandlung eines Vitamin-D-Mangels geben. Die Ausführungen stützen sich im Wesentlichen auf einen Artikel Holick aus dem Jahr 2024 1 die et al. 2011 Demay publizierten Leitlinien Endocrine Society 2, 3, wobei jüngste Leitlinie Gegensatz eine Risikobewertung Vitamin-D-assoziierten Erkrankungen bei Individuen mit bisher nicht etablierten Indikationen für Vitamin-D-Supplementation bzw. -Messung abzielt.

Citations

0
Vitamin D: A Nutraceutical Supplement at the Crossroad Between Respiratory Infections and COVID-19 DOI Open Access
Manuela Rizzi, Pier Paolo Sainaghi

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2550 - 2550

Published: March 12, 2025

Even though in mid-2023 the World Health Organization declared end of public health emergency international concern status for COVID-19, many areas uncertainty about SARS-CoV-2 infection pathophysiology remain. Although last 4 years pharmaceutical industries widely invested development effective antiviral treatments and vaccines, large disparities their availability worldwide still exist, thus fostering investigation nutritional supplements as adjuvant therapeutic approaches disease management, especially resource-limited settings. During COVID-19 pandemic, vitamin D has been used an over-the-counter solution to improve evolution, thanks its known immunomodulatory anti-inflammatory actions. Ecological observational studies support a relationship between hypovitaminosis negative outcomes and, according this evidence, several research groups investigated role supplementation protecting from and/or improving evolution. This narrative review is intended offer insights into existing data on D’s biological effects respiratory infections, COVID-19. Furthermore, it will also brief overview complex interplay vaccine-elicited immune response, with special attention anti-COVID-19 vaccines.

Language: Английский

Citations

0