Citric Acid-Catalyzed Three-Component Synthesis of (E)-3-Aryl-2-styryl-2,3-dihydroquinazoline-4(1H)-ones and Their Mild Oxidation with I2/DMSO System into (E)-3-Aryl-2-styrylquinazolin-4(3H)-ones DOI Creative Commons
Vladímir V. Kouznetsov,

Angélica Peñaranda Gómez,

Carlos E. Puerto Galvis

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(2), P. 42 - 42

Published: March 16, 2025

We hereby report a simple and efficient method for the preparation of (E)-3-aryl-2-styryl-2,3-dihydroquinazolin-4-(1H)-ones, from isatoic anhydride, anilines, cinnamaldehydes in presence 20 mol% citric acid methanol at 60 °C 2 h. The styryl-dihydroquinazolin-4-(1H)-one products were obtained moderate good yields (30–80%) through three-component condensation reaction, under an environment-friendly protocol. latter easily transformed into styrylquinazolin-4-(3H)-one derivatives with 57–91% using mild oxidation I2/DMSO system less than min.

Language: Английский

Citric Acid-Catalyzed Three-Component Synthesis of (E)-3-Aryl-2-styryl-2,3-dihydroquinazoline-4(1H)-ones and Their Mild Oxidation with I2/DMSO System into (E)-3-Aryl-2-styrylquinazolin-4(3H)-ones DOI Creative Commons
Vladímir V. Kouznetsov,

Angélica Peñaranda Gómez,

Carlos E. Puerto Galvis

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(2), P. 42 - 42

Published: March 16, 2025

We hereby report a simple and efficient method for the preparation of (E)-3-aryl-2-styryl-2,3-dihydroquinazolin-4-(1H)-ones, from isatoic anhydride, anilines, cinnamaldehydes in presence 20 mol% citric acid methanol at 60 °C 2 h. The styryl-dihydroquinazolin-4-(1H)-one products were obtained moderate good yields (30–80%) through three-component condensation reaction, under an environment-friendly protocol. latter easily transformed into styrylquinazolin-4-(3H)-one derivatives with 57–91% using mild oxidation I2/DMSO system less than min.

Language: Английский

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