Frontiers in Aging,
Journal Year:
2024,
Volume and Issue:
5
Published: July 11, 2024
Introduction
Centella
asiatica
(CA)
is
known
in
Ayurvedic
medicine
as
a
rejuvenating
herb
with
particular
benefits
the
nervous
system.
Two
groups
of
specialized
metabolites
found
CA
and
purported
to
contribute
its
beneficial
effects
are
triterpenes
(TTs)
caffeoylquinic
acids
(CQAs).
In
order
evaluate
role
interactions
TTs
CQAs
CA,
we
examined
neurotrophic
water
extract
(CAW)
combinations
TT
CQA
components
mouse
primary
hippocampal
neurons
vitro
Drosophila
melanogaster
flies
vivo
.
Methods
Primary
were
isolated
from
embryos
exposed
for
5
days
CAW
(50
μg/mL),
mixtures
TTs,
or
+
4
8
individual
compounds
CAW.
Dendritic
arborization
was
evaluated
using
Sholl
analysis.
aged
28
treated
2
weeks
(10
mg/mL)
food,
compounds.
tested
at
concentrations
matching
their
levels
treatment
used.
After
treatment,
42
phototaxis
responses.
Results
neurons,
mix,
all
most
significantly
increased
dendritic
greater
than
control
levels.
However,
combination
decreased
arborization.
Drosophila,
marked
age-related
decline
fast
response
observed
both
males
females
over
60
period.
resilience
this
afforded
male
female
by
onwards
mg/mL),
equivalent
mixed
mix.
Of
compounds,
only
1,5-diCQA
slowed
flies.
Discussion
This
study
confirmed
ability
increase
neuronal
arborization,
provide
neurological
The
these
but
do
not
have
synergistic
effect.
While
concentrations,
model,
able
slow
down
phototaxis.
suggests
that
(or
potentially
higher
concentrations)
other
needed
model.
Life,
Journal Year:
2023,
Volume and Issue:
13(7), P. 1514 - 1514
Published: July 5, 2023
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
inflammatory
disease
characterized
by
joint
inflammation,
swelling
and
pain.
Although
RA
mainly
affects
the
joints,
can
also
have
systemic
implications.
The
presence
of
autoantibodies,
such
as
anti-cyclic
citrullinated
peptide
antibodies
rheumatoid
factors,
hallmark
disease.
significant
cause
disability
worldwide
associated
with
advancing
age,
genetic
predisposition,
infectious
agents,
obesity
smoking,
among
other
risk
factors.
Currently,
treatment
depends
on
anti-inflammatory
disease-modifying
anti-rheumatic
drugs
intended
to
reduce
inflammation
pain,
preventing
or
slowing
down
damage
progression.
However,
these
are
severe
side
effects
upon
long-term
use,
including
immunosuppression
development
opportunistic
infections.
Natural
products,
namely
triterpenes
properties,
shown
relevant
anti-arthritic
activity
in
several
animal
models
without
undesirable
effects.
Therefore,
this
review
covers
recent
studies
(2017-2022)
safe
promising
drug
candidates
for
RA.
These
bioactive
compounds
were
able
produce
reduction
indices
immunological
markers.
Celastrol,
betulinic
acid,
nimbolide
some
ginsenosides
stand
out
most
treatment.
Compounds,
Journal Year:
2025,
Volume and Issue:
5(1), P. 2 - 2
Published: Jan. 3, 2025
Plant-derived
secondary
metabolites
such
as
triterpenes
and
triterpenoids
are
present
in
a
wide
range
of
plant
species.
These
compounds
particularly
attractive
due
to
their
extensive
biological
properties
potential
applications
intermediates
the
synthesis
novel
pharmacologically
promising
medications.
Saponins,
which
glycosylated
found
nature,
exhibit
same
properties.
At
this
point,
effectiveness
saponins
an
anti-inflammatory
medication
has
been
verified.
This
review
article
examines
primary
connections
between
immune
responses
activity,
focusing
specifically
on
correlation
triterpenoids.
have
investigated
various
cell
models,
well
vitro
vivo
studies.
The
research
provides
comprehensive
overview
current
understanding
therapeutic
capabilities
inflammatory
processes.
It
also
highlights
emerging
standards
utilization
pharmaceutical
clinical
settings.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 217 - 234
Published: March 7, 2025
Terpenes
are
a
broad
and
varied
group
of
organic
compounds
found
in
numerous
plants,
especially
conifers,
some
insects.
They
known
for
imparting
aromatic
properties
to
these
organisms.
Recently,
there
is
growing
interest
terpenes
due
their
wide-range
applications
increase
demand
natural
products.
This
surge
particularly
evident
the
cosmetic,
pharmaceutical,
food
industries,
where
ingredients
has
significantly
boosted
appeal
terpenes.
Additionally,
role
traditional
medicine
provided
historical
context
that
supported
modern
use,
subsequent
cancer
therapeutics.
For
past
few
decades,
studies
have
been
conducted
delve
deeper
into
potential
oncotherapeutic
effect
terpenes,
with
in-vivo
in-vitro
being
carried
out
rapidly.
However,
lack
clinical
trials,
use
practically
as
well
commercially,
become
questionable
recent
times.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(4), P. 269 - 269
Published: April 10, 2025
With
the
increasing
attention
of
modern
medicine
to
natural
medicinal
agents,
Inonotus
obliquus
(chaga),
a
macrofungus
with
remarkable
value,
has
gradually
garnered
widespread
academic
interest.
This
paper
reviews
primary
bioactive
components
I.
in
recent
years,
including
polysaccharides,
phenolic
compounds,
and
triterpenoids,
which
exhibit
diverse
pharmacological
effects
such
as
antioxidant,
anti-inflammatory,
immunomodulatory,
antitumor
activities.
It
further
discusses
how
these
enhance
human
health
disease
resistance
through
distinct
biological
mechanisms,
activation
antioxidant
systems,
regulation
immune
responses,
modulation
apoptosis
pathways.
Additionally,
article
explores
biosynthetic
pathways
metabolites
their
relevance.
Finally,
we
summarize
potential
resource
envisage
its
future
applications
clinical
drug
development.
review
aims
provide
novel
perspectives
for
cultivation,
utilization,
industrial-scale
exploitation
obliquus.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: April 11, 2025
Polygonatum
is
a
traditional
medicinal
and
edible
plant
often
prepared
by
steaming
it
with
ingredients
like
yellow
rice
wine
black
beans.
However,
the
metabolic
changes
in
kingianum
(PK)
during
method
beans
have
not
been
previously
reported.
This
study
aims
to
explore
how
addition
of
degree
affect
quality
PK.
quantified
polysaccharides,
reducing
sugars,
saponins,
flavonoids
PK
subjected
varied
cycles,
while
also
integrating
color
measurement,
sensory
evaluation,
non-targeted
metabolomics
analysis.
rich
lipids,
amino
acids,
flavonoids,
organic
acids.
Notably,
we
observed
production
significant
accumulation
daidzein
daidzin
(two
primary
active
compounds
derived
from
beans)
as
well
triterpenoid
saponins
(including
Sandosaponin
A,
Soyasaponin
II-III,
V,
Pisumsaponin
I-II)
steamed
(p
<
0.05).
After
three
multiple
bioactive
levels
peaked
or
stabilized,
which
was
consistent
(score:
94/100).
Compared
raw
PK,
P3
stage
exhibited
increases
total
21.29,
35.02,
49.13,
44.76%,
respectively
0.05),
sugars
showed
remarkable
increase
160.94-fold
0.01),
polysaccharides
decreased
significantly
43.33%
0.01).
provides
first
evidence
that
can
synergistically
diversity
isoflavones
optimal
achieved
after
rounds
steaming.
These
findings
validate
scientific
efficacy
processing
method.
Our
results
advocate
for
continued
use
bean
enhance
nutritional
health-promoting
value
providing
template
innovation
herbal
techniques
based
on
auxiliary
ingredients.
