The effect of curcumin supplementation on circulating adiponectin and leptin concentration in adults: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials

British Journal Of Nutrition, Journal Year: 2023, Volume and Issue: 131(6), P. 964 - 973

Published: Nov. 20, 2023

Abstract Curcumin is a phytocompound found in the root of turmeric, common herbal ingredient many Asian cuisines. The compound contains anti-inflammatory activity, which mediated through an upregulation adiponectin and reduction leptin. Results randomised controlled trials (RCT) have shown that effects curcumin on adipokines are conflicting. Therefore, current systematic review meta-analysis RCT were conducted with aim elucidating role supplementation serum search included PubMed, Embase, Cochrane Library, Scopus, Web Science Google Scholar from inception to August 2023. For net changes adipokines, standardised mean differences (SMD) calculated using random models. Thirteen fourteen treatment arms eligible for inclusion this meta-analysis. was effective increasing (SMD = 0·86, 95 % CI (0·33, 1·39), P < 0·001; I 2 93·1 %, 0·001) reducing leptin −1·42, (−2·29, −0·54), 94·7 0·001). In conclusion, significantly increased circulating decreased levels adults.

Language: Английский

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Nanocarrier-mediated curcumin delivery: An adjuvant strategy for CNS disease treatment

Experimental Biology and Medicine, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 6, 2023

Neurological disorders are a major global challenge, which counts for substantial slice of disease burden around the globe. In these, challenging landscape central nervous system (CNS) diseases, including Alzheimer’s disease, Parkinson’s multiple sclerosis, and neuro-AIDS, demands innovative novel therapeutic approaches. Curcumin, versatile natural compound with antioxidant anti-inflammatory properties, shows great potential as CNS adjuvant therapy. However, its limited bioavailability suboptimal permeability to blood–brain barrier (BBB) hamper efficacy curcumin. This review explores how nanocarrier facilitates curcumin delivery, has shown various non-CNS example, cancers, can also revolutionize treatment outcomes in patients diseases. Toward this, intranasal administration non-invasive drug delivery route aid an therapy Intranasal nanocarriers improves BBB permeability, is instrumental promoting potential. Furthermore, curcumin’s inhibitory effect on efflux transporters will help enhance cellular drugs. The yield synergistic effects drugs reduce doses improve their safety profile. Taken together, this approach holds promise reshaping management by maximizing other drugs’ benefits.

Language: Английский

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Low curcumin concentrations combined with blue light inhibits cutibacterium acnes biofilm-induced inflammatory response through suppressing MAPK and NF-κB in keratinocytes

Photodiagnosis and Photodynamic Therapy, Journal Year: 2022, Volume and Issue: 40, P. 103204 - 103204

Published: Nov. 17, 2022

Language: Английский

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Synaptic and mitochondrial alterations in traumatic brain injury (TBI): neuroprotective effects of phytochemicals and herbal products

Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 205 - 228

Published: Jan. 1, 2023

Language: Английский

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Chemical Features and Therapeutic Applications of Curcumin (A Review)

Russian Journal of General Chemistry, Journal Year: 2022, Volume and Issue: 92(9), P. 1785 - 1805

Published: Sept. 1, 2022

Language: Английский

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