The first complete mitochondrial genome of Curcuma amarissima (Zingiberaceae): insights into multi-branch structure, codon usage, and phylogenetic evolution

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 5, 2025

As a key genus in Zingiberaceae, Curcuma is widely studied for its taxonomic diversity, the presence of bioactive curcuminoids and volatile oils, extensive applications traditional medicine economic products such as spices cosmetics. Although chloroplast genomes have been assembled published over 20 species, mitochondrial genomic data remain limited. We successfully sequenced, assembled, annotated mitogenome amarissima (C. amarissima) using both Illumina short reads Nanopore long reads, achieving first complete characterization Zingiberaceae family. The C. features unique multi-branched structure, spanning 6,505,655 bp consisting 39 distinct segments. It contains total 43 protein-coding genes, 63 tRNA 4 rRNA with GC content 44.04%. Codon usage analysis indicated weak bias, neutrality plot suggesting natural selection factor shaping codon amarissima. provides valuable insights into genome size, coding structural features, RNA editing, repetitive sequences, sequence migration, enhancing our understanding evolution molecular biology mitochondria Zingiberaceae. high frequency repeat sequences may contribute to stability mitochondria. Comparing genome, phylogenetic based on establishes foundation further exploration evolutionary relationships within In short, characterized here advances organization offers useful resources that support future breeding, germplasm conservation, studies, though research necessary.

Language: Английский

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Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trial

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

Migraines are neurological disorders which significantly impact quality of life. Current pharmacological treatments often have adverse effects, prompting the search for alternatives with fewer side effects. Several studies described antimigraine properties palmitoylethanolamide (PEA) and melatonin. Our research assessed efficacy association hydrodispersible PEA (1,200 mg) melatonin (0.2 by a randomized, three-month, double-blind, placebo-controlled trial (PEATONIDE®; n = 30 patients; placebo; patients). The participants were recruited "I.N.B.B. Consortium" in Italy. primary outcome was reduction migraine frequency, while secondary outcomes included intensity, duration, grade disability. parameters self-reported daily headache diary. formulation displayed significant frequency (T3 months: 2.2 ± 0.4 MMDs; T0 baseline: 3.4 0.5 MMDs, ***p < 0.001 vs baseline T0) disability, incidence associated symptoms attacks after 3 months treatment. No effects observed during In addition, mitigation migraine-related symptomatology observed. These findings suggest that PEATONIDE® may be promising adjunctive approach management. However, given relatively small sample size, further large-scale multicenter trials needed to confirm its clinical applicability broader population.

Language: Английский

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Phytochemical studies of plant extracts enclosed in chitosan microparticles and the effect of phytoformulations on skin condition

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113968 - 113968

Published: May 1, 2025

Language: Английский

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Curcumin: a potential anti-photoaging agent

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 6, 2025

Turmeric, also referred to as Curcuma longa, is a commonly used spice, recognized for its demonstrated effects in reducing inflammation, combating microbes, providing antioxidant benefits, slowing the aging process, and exhibiting anticancer potential. The process of skin intricate, with ultraviolet radiation being significant extrinsic factor. Increasing evidence suggests that curcumin, active component turmeric, can prevent radiation-induced photoaging related inflammation. Its include inhibition melanin production, wrinkle reduction, anti-inflammatory actions. This review primarily focuses on specific signaling pathways involved mechanisms by which curcumin mitigates photoaging. Key topics properties regulation matrix metalloproteinase, autophagy apoptosis, improvement pigmentation, microbial balance. Additionally, addressing critical issue curcumin's low bioavailability, summarizes latest advancements formulation improvements. article aims provide comprehensive overview progress research offer further clinical application dermatological treatments. contributes deeper understanding potential molecular presents new insights development curcumin-based anti-photoaging products.

Language: Английский

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Anti-Aging Potential of Plants of the Anak Dalam Tribe, Jambi, Indonesia

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1300 - 1300

Published: Sept. 14, 2023

The process of skin aging is a physiological phenomenon that can not be avoided. According to global population data, the rate increases by approximately 13% every year. impact has become significant concern and challenge for developed countries. Consequently, there been search potential new anti-aging agents. This review aims provide an overview current research status plants Anak Dalam Tribe (Indonesian: Suku [SAD]; referred as SAD henceforth) in Jambi Province, Indonesia, development One such discovery product derived from natural ingredients with ability prevent premature aging. These have used centuries tribe, treating diseases maintaining health through traditional remedies. Recent on herbal formulations community Indonesia beauty treatments, reported Research Medicinal Plants Herbs or RISTOJA, indicates 64 plant species are care. Among these plants, Toona sinensis, Curcuma heyneana, zedoaria, longa, Kaempferia rotunda most commonly medicinal properties. T. sinensis tree, while others herbs. shows highest agent, its extracts, active fractions, bioactive quercetin isolates known possess strong activities both vitro vivo. Furthermore, C. K. also show further research, three them demonstrated good vivo activities. Only demonstrates relatively weaker antioxidant activity compared zedoaria. Nevertheless, still opportunities agents other activities, zedoaria findings could opportunity explore In conclusion, five traditionally Jambi, longa received extensive solutions. heyneana activity. least-studied plant. it development, widely medicine

Language: Английский

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Effects of Food-Derived Antioxidant Compounds on In Vitro Heavy Metal Intestinal Bioaccessibility

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 610 - 610

Published: May 16, 2024

Environmental contamination by heavy metals (HMs) has emerged as a significant global issue in recent decades. Among natural substances, food-deriving polyphenols have found valuable application chelating therapy, partially limited their low water solubility. Thus, three different hydroalcoholic extracts titrated quercetin (QE), ellagic acid (EA), and curcumin (CUR) were formulated using maltodextrins carriers, achieving powder with solubility (MQE 91.3 ± 1.2%, MEA 93.4 2.1, MCUR 89.3 2%). Overcoming the problem of solubility, such formulations tested an vitro simulated gastrointestinal digestion experiment conducted on sample standardized concentrations principal HMs. Our results indicate that regarding nonessential HMs investigated (Pb, Cd, As, Sb, Hg), MQE been shown to be most effective increasing HMs’ non-bioaccessible concentration, resulting concentration increases Cd 68.3%, As 51.9%, Hg 58.9%, Pb 271.4, Sb 111.2% (vs control, p < 0.001) fractions. Regarding essential HMs, greatest capability increase intestinal bioaccessibility, +68.5%, +61.1, +22.3% Cu, Zn, Fe, respectively. Finally, considering strong relation between antiradical activities, radical scavenging potentials was assayed DPPH ABTS assays.

Language: Английский

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NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4282 - 4282

Published: April 12, 2024

In recent years, there has been increasing interest in utilizing Traditional Chinese Medicine principles and natural bioactive compounds to combat age-related ailments enhance longevity. A Cordyceps sinensis mycelium hydroethanolic extract (CsEx), which was standardized cordycepin adenosine using UHPLC-DAD, investigated for its adaptogenic properties vitro assays a double-blind, placebo-controlled clinical trial involving 40 subjects. The CsEx demonstrated activity at concentration of 0.0006%, significantly sirtuin expression (SirT1: +33%, SirT3: +10%, SirT6: +72%, vs. CTR, p < 0.05) NAD+ synthesis HaCat cells (+20% 0.001). Moreover, the boosted ATP production by 68% skin cells, correlating with higher energy values (+52.0% D28, 0.01) trial. Additionally, notably reduced cytosolic reactive oxygen species (ROS) 30% HaCaT (p enhanced collagen both (+69% vivo (+10% D0, 0.01), confirmed ultrasound examination. Furthermore, CsEx’s stimulation fibroblasts, coupled antioxidant energizing properties, led significant reduction wrinkles 28.0% (D28, This study underscores extract’s potential regulating cell metabolism positively influencing mechanisms associated longevity control.

Language: Английский

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Optimization and Validation of Procyanidins Extraction and Phytochemical Profiling of Seven Herbal Matrices of Nutraceutical Interest

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 586 - 586

Published: May 10, 2024

Several medicinal herbal plants are extensively used as sources of bioactive compounds with beneficial effects on human health. This study assessed the procyanidin and polyphenol profiles together antioxidant potential seven medical matrices. To achieve this aim, extraction from grape pomace was optimized validated by monitoring monomeric-trimeric procyanidins. The proposed quantification method applied to herbs, it proved be a very efficient protocol for procyanidin-rich extracts analysis. In addition, Paullinia cupana Kunth. seed identified rich source procyanidins (about 5 mg/g dry matrix each dimeric about 3 trimeric) high properties. polyphenolic profile HPLC-HESI-MS/MS in vitro activity evaluated DPPH assay explore properties extracts, which were substantially higher Peumus boldus Molina leaves (935.23 ± 169 μmol Trolox equivalent/g weight) concerning other Moreover, Pearson coefficient value observed between total flavonoid content (TFC) comparison (TPC) DPPH, indicating flavonoids principal extracts.

Language: Английский

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A Study of Efficacy and Safety of Ashwagandha (Withania somnifera) Lotion on Facial Skin in Photoaged Healthy Adults

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: March 15, 2023

Background Facial skin has an essential cosmetic function in both men and women, photoaged can affect the quality of life healthy people. Ashwagandha (Withania somnifera) which is also called Indian ginseng adaptogenic properties used traditional medicine to maintain balance, energize, rejuvenate. Objective This randomized, double-blind, placebo-controlled study assessed efficacy safety topical application lotion containing 8% standardized root extract on improvement parameters facial subjects. Methods Fifty-six women aged between 18 60 years with Fitzpatrick phototype III-VI grade were randomized receive (lotion skin) either (AG, n=28), or identical placebo (PL, n=28) for days. The primary outcome was change from baseline day scores global physician assessment scoring five dermatological signs (skin wrinkles, pores, hydration/moisture, brightness/tone, pigmentation) skin. Secondary outcomes changes transepidermal water loss (TEWL), melanin index, hydration, elasticity (R2 ratio). Another using health-specific Short Form Health Survey-12 (SF-12). Safety local reactions adverse events. Three (1 AG, 2 PL) patients lost follow-up per-protocol (PP) data included 53 (27 26 PL). For measurement data, repeated measures analysis variance (ANOVA) assess treatment effect at different time periods PP dataset (n=53). Two groups compared differences a t-test continuous Mann-Whitney ‘U’ test ordinal data. Adverse events two chi-square test. Results Greater reduction (p<0.0001) total observed AG (-74.69%) PL (-48.68%). There greater TEWL, ratio) as (p<0.0001). However, index similar end (p=0.969). percentage increase by -2.82% -1.78% PL, whereas TEWL -15.12% -8.34% PL. Similarly, improvements seen hydration (20.66% 9.5% R2 ratio (16.34% 3.73% comparable groups. Conclusions Topical improves condition individuals. Further studies types standard comparators are warranted substantiate these claims benefit.

Language: Английский

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Advancing Lip Augmentation: State-of-the-Art 2D and 3D Analysis for Assessing Volume Enhancement and Lip Line Redefinition

Cosmetics, Journal Year: 2024, Volume and Issue: 11(3), P. 70 - 70

Published: May 3, 2024

Over the preceding five decades, there has been a noticeable surge in pursuit of achieving voluminous and well-defined lips. This trend prompted an escalating number individuals to undergo lip augmentation procedures, aiming for natural three-dimensional enhancement volume distinct vermilion borders. Despite proliferation techniques, remains dearth comprehensive investigations into their precise effects on structural integrity research endeavors address this gap by employing stereophotogrammetry as quantitative tool scrutinize outcomes appraise efficacy plumpers. The study methodology involves comparative analysis dimensions among subjects treated with commercial plumper using multi-spectral imaging dimension assessment, coupled markerless tracking technology 3D interpolating surface analyze shape. Additionally, evaluated youth state, including moisture level, softness, firmness, tissue density. demand procedures is driven perceived advantages such quick recovery minimal risk. Therefore, it crucial substantiate robust findings. investigation suggests that both 2D techniques are reliable evaluating size before after augmentation, whether through cosmetic or aesthetic approaches. Overall, provides treatment aimed at enhancing redesigning lines. It demonstrates effective assessing correlation internal structure. could be particularly valuable duration various dermal fillers, implants, topical formulations, offering reproducible assessments over time.

Language: Английский

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