Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(51)
Published: Nov. 1, 2023
Abstract
The
glutathione
(GSH)
system
is
one
of
the
most
powerful
intracellular
antioxidant
systems
for
elimination
reactive
oxygen
species
(ROS)
and
maintaining
cellular
redox
homeostasis.
However,
rapid
kinetics
information
(at
millisecond
to
second
level)
during
dynamic
antioxidation
process
GSH
remains
unclear.
As
such,
we
specifically
developed
a
novel
dual‐wire
nanosensor
(DWNS)
that
can
selectively
synchronously
measure
levels
ROS
with
high
temporal
resolution,
applied
it
monitor
transient
generation
as
well
in
individual
cancer
cells.
These
measurements
revealed
peroxidase
(GPx)
rapidly
initiated
against
burst
sub‐second
time
scale,
but
short‐lived,
ending
after
few
seconds,
while
some
are
still
present
This
study
expected
open
new
perspectives
understanding
studying
imbalance‐related
physiological.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: April 2, 2025
Cellular
senescence,
a
stable
state
of
cell
cycle
arrest
induced
by
various
stressors
or
genomic
damage,
is
recognized
as
hallmark
cancer.
It
exerts
context-dependent
dual
role
in
cancer
initiation
and
progression,
functioning
tumor
suppressor
promoter.
The
complexity
senescence
arises
from
its
mechanistic
diversity,
potential
reversibility,
heterogeneity.
A
key
mediator
these
effects
the
senescence-associated
secretory
phenotype
(SASP),
repertoire
bioactive
molecules
that
influence
microenvironment
(TME)
remodeling,
modulate
behavior,
contribute
to
therapeutic
resistance.
Given
intricate
biology,
presents
both
challenges
opportunities
for
intervention.
Strategies
targeting
pathways,
including
senescence-inducing
therapies
senolytic
approaches,
offer
promising
avenues
treatment.
This
review
provides
comprehensive
analysis
regulatory
mechanisms
governing
cellular
tumors.
We
also
discuss
emerging
strategies
highlighting
novel
opportunities.
deeper
understanding
processes
essential
developing
precision
improving
clinical
outcomes.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3136 - 3136
Published: July 13, 2023
Polyphenols
derived
from
fruits,
vegetables,
and
plants
are
bioactive
compounds
potentially
beneficial
to
human
health.
Notably,
such
as
quercetin,
curcumin,
epigallocatechin-3-gallate
(EGCG),
resveratrol
have
been
highlighted
antiproliferative
agents
for
cancer.
Due
their
low
solubility
limited
bioavailability,
some
alternative
nanotechnologies
applied
encapsulate
these
compounds,
aiming
improve
efficacy
against
In
this
comprehensive
review,
we
evaluate
the
main
nanotechnology
approaches
therapeutic
potential
of
polyphenols
cancer
using
in
vitro
studies
vivo
preclinical
models,
highlighting
recent
advancements
field.
It
was
found
that
polymeric
nanomaterials,
lipid-based
inorganic
carbon-based
nanomaterials
most
used
classes
nanocarriers
encapsulating
polyphenols.
These
delivery
systems
exhibit
enhanced
antitumor
activity
pro-apoptotic
effects,
particularly
breast,
lung,
prostate,
cervical,
colorectal
cells,
surpassing
performance
free
compounds.
Preclinical
trials
xenograft
animal
models
revealed
decreased
tumor
growth
after
treatment
with
polyphenol-loaded
systems.
Moreover,
interaction
polyphenol
co-delivery
polyphenol–drug
is
a
promising
approach
increase
anticancer
decrease
chemotherapy
side
effects.
innovative
hold
significant
implications
advancement
clinical
research.
Frontiers in Bioscience-Landmark,
Journal Year:
2023,
Volume and Issue:
28(9)
Published: Sept. 14, 2023
Pulmonary
fibrosis
(PF)
is
a
feared
component
in
over
200
interstitial
pulmonary
diseases,
which
are
characterized
by
increased
alveolar
wall
thickness,
excessive
scarring,
and
aberrant
extracellular
matrix
restructuring
that,
ultimately,
affect
lung
compliance
capacity.
As
result
of
its
broad
range
biological
activities,
including
antioxidant,
anti-inflammatory,
antiapoptotic,
many
others,
resveratrol
has
been
shown
to
be
an
effective
treatment
for
respiratory
system
disease,
infectious
cancer.
This
work
reviews
the
known
molecular
therapeutic
targets
potential
mechanisms
action
attenuating
PF
cancer,
COVID-19,
diseases
(ILDs)
etiologies,
idiopathic
pneumonia,
ILDs
associated
with
systemic
disorders,
such
as
rheumatoid
arthritis,
sclerosis,
Schrödinger’s
syndrome,
lupus
erythematosus,
hypertension.
The
current
issues
controversies
related
possible
use
pharmaceutical
drug
or
supplement
also
discussed.
iScience,
Journal Year:
2024,
Volume and Issue:
27(2), P. 108885 - 108885
Published: Jan. 13, 2024
Resistance
to
cisplatin
(cis-dichlorodiamineplatinum,
DDP)
in
ovarian
cancer
is
a
significant
clinical
challenge.
Epigallocatechin-3-gallate
(EGCG)
has
shown
promise
therapy.
However,
its
effects
on
DDP-resistant
remain
understudied.
This
study
aims
assess
the
impact
of
EGCG
cells
and
elucidate
associated
molecular
mechanisms.
cell
lines
were
utilized
for
biological
characterization.
effectively
inhibited
proliferation,
mobility,
induced
apoptosis
OC/DDP
cells.
It
downregulated
expression
S100A4
NF-κB
while
upregulating
p53
expression.
These
reversed
upon
overexpression
or
NF-κB.
In
vivo
experiments
confirmed
tumor
inhibition
KI67
by
EGCG.
Moreover,
xenograft
mice
compared
those
without
treatment.
suggests
that
suppresses
progression
through
S100A4/NF-κB
signaling
pathway,
involving
interaction
with
p53.
holds
potential
as
an
anticancer
candidate
OC/DDP.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(51)
Published: Nov. 1, 2023
Abstract
The
glutathione
(GSH)
system
is
one
of
the
most
powerful
intracellular
antioxidant
systems
for
elimination
reactive
oxygen
species
(ROS)
and
maintaining
cellular
redox
homeostasis.
However,
rapid
kinetics
information
(at
millisecond
to
second
level)
during
dynamic
antioxidation
process
GSH
remains
unclear.
As
such,
we
specifically
developed
a
novel
dual‐wire
nanosensor
(DWNS)
that
can
selectively
synchronously
measure
levels
ROS
with
high
temporal
resolution,
applied
it
monitor
transient
generation
as
well
in
individual
cancer
cells.
These
measurements
revealed
peroxidase
(GPx)
rapidly
initiated
against
burst
sub‐second
time
scale,
but
short‐lived,
ending
after
few
seconds,
while
some
are
still
present
This
study
expected
open
new
perspectives
understanding
studying
imbalance‐related
physiological.
Cell Reports,
Journal Year:
2025,
Volume and Issue:
44(4), P. 115517 - 115517
Published: April 1, 2025
Resveratrol
(RSV)
is
a
plant-derived
natural
compound
with
multiple
biological
activities.
Upon
entering
the
intestine,
RSV
undergoes
rapid
metabolism
and
transformation
by
gut
microbiota.
In
this
study,
we
isolated
bacterium
capable
of
efficiently
metabolizing
RSV,
Eggerthella
lenta
J01.
Through
induced
enrichment
transcriptomics
bioinformatic
analyses,
identified
an
reductase
(RER)
from
E.
Using
RER
structure
simulation,
site-directed
mutagenesis,
biochemical
assays,
further
determined
key
amino
acids
in
associated
catalytic
activity.
Studies
animal
models
demonstrated
that
enhances
RSV's
ability
to
alleviate
inflammatory
bowel
disease.
Additionally,
bioinformatics
analysis
revealed
abundance
rer
gene
microbiota
healthy
individuals
was
higher
than
patients
enteritis.
Collectively,
these
findings
suggest
activity
products
may
be
modulated
through
metabolic
transformations.
