Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics DOI Creative Commons
Peng Liu, Xizhuo Hu, Zhiqiang Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 25, 2024

Resveratrol, a naturally occurring polyphenolic compound, has captivated the scientific community with its promising therapeutic potential across spectrum of diseases. This review explores complex role resveratrol in modulating ferroptosis, newly identified form programmed cell death, and implications for managing cardiovascular cerebrovascular disorders, cancer, other conditions. Ferroptosis is intricately linked to pathogenesis diverse diseases, exerting multifaceted effects on this process. It mitigates ferroptosis by lipid peroxidation, iron accumulation, engaging specific cellular receptors, thereby manifesting profound benefits conditions, as well oncological settings. Moreover, resveratrol's capacity either suppress or induce through modulation signaling pathways, including Sirt1 Nrf2, unveils novel avenues. Despite limited bioavailability, advancements molecular modification drug delivery optimization have amplified clinical utility. Future investigations are poised unravel comprehensive mechanisms underpinning action expand repertoire. We hope could furnish detailed insight into exploration regulation prospects.

Language: Английский

Recent advances and applications of novel advanced materials in solid-phase microextraction for natural products DOI

Huang-Fei Jin,

Ying Shi,

Jun Cao

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 178, P. 117858 - 117858

Published: July 6, 2024

Language: Английский

Citations

17
Rabdosia rubescens (Hemsl.) H. Hara: A Potent Anti-Tumor Herbal Remedy - Botany, Phytochemistry, and Clinical Breakthroughs DOI
Shiyong Gao,

Li JianWen,

Weiya Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119200 - 119200

Published: Dec. 3, 2024

Language: Английский

Citations

9
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

8
Targeting ferroptosis regulators by natural products in colorectal cancer DOI Creative Commons
Yiping Zhang, Jun Xie

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 27, 2024

Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed and second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such delayed diagnosis, multidrug resistance, limited therapeutic effectiveness persist, emphasizing need for innovative approaches. This review explores potential natural products, nutraceuticals, phytochemicals targeting ferroptosis-related regulators novel strategy CRC. Ferroptosis, form regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance CRC progression therapy resistance. Natural known their diverse bioactive effects favorable safety profiles, emerge promising candidates to induce ferroptosis cells. Exploring amino acid, iron, metabolism regulators, oxidative stress reveals avenues inducing comprehensive provides insights into multifaceted products on proteins integral regulation, including GPX4, SLC7A11, ACSL4, NCOA4, HO-1. By elucidating intricate mechanisms through which modulate these proteins, this lays foundation

Language: Английский

Citations

7
Synthesis of Ethylphosphonate Curcumin Mimics: Substituents Allow Switching Between Cytotoxic and Cytoprotective Activities DOI Creative Commons
Valeria Romanucci, Rita Pagano, Solveigh C. Koeberle

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 412 - 412

Published: March 29, 2025

Curcumin is recognized for its diverse biological activities, including the ability to induce apoptosis and ferroptosis. Therefore, it represents a promising candidate development of new compounds with neuroprotective anticancer properties. In order synthesize mimics improved pharmacokinetic properties (better solubility stability than curcumin) here, we present design synthesis novel curcumin analogues named Ethylphosphonate-based (EPs), which preserve pharmacophoric features curcumin. New EP were synthesized by tyrosol- melatonin-based building blocks using an orthogonal protection approach different precursors’ OH functions good yields in few steps. Comparative screenings cytotoxic cytoprotective (curcumin was used as reference compound) carried out on all cell lines (HeLa, A375, WM266, MDA-MB-231, LX2, HDF). Assays inhibitors ferroptosis (Ferrostatin-1, Fer-1) (Quinoline-Val-Asp-difluorophenoxymethyl ketone, Q-VD), combination curcumin, suggested specific death pathway (apoptotic or ferroptotic) EPs, depending aromatic moieties contained them. Interestingly, EP4 exhibited substantial effects against various human cancer WM266) while sparing normal cells (HDFs). displayed five-times-higher toxicity triple-negative MDA-MB-231 LX2 stellate The cytotoxicity exerted involves only apoptotic mechanism, contrary exerts both ferroptotic effects. Additionally, also found be very potent inhibitor ubiquitin-activating enzyme E1, reinforcing potential this compound. Furthermore, EP2 possesses high antioxidant properties, efficiently protects ferroptosis, inhibits amyloid aggregation involved AD.

Language: Английский

Citations

0
Natural compounds targeting ferroptosis in ovarian cancer: research progress and application potential DOI Creative Commons

Yuanyuan Zhao,

Ling Lü, Xingying Chen

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107729 - 107729

Published: April 1, 2025

Ovarian cancer (OC) is among the most common malignancies in female reproductive system, marked by high rates of recurrence and mortality. Conventional chemotherapy, however, faces limitations due to development drug resistance, which hinders its effectiveness. Ferroptosis, an atypical form programmed cell death distinct from autophagy, apoptosis, necrosis, relationship with tumors has become a hot research area studies recent years. Anticancer therapies that target ferroptosis show strong potential improving prognosis counteracting chemotherapy resistance. Natural compounds, as valuable source novel targeted anticancer agents, significant role inhibiting tumor proliferation metastasis therapeutic sensitivity been demonstrated numerous existing studies. This review summarizes range natural compounds OC cells, discussing their active components, mechanisms action, potential, thereby providing useful insights for future therapy OC.

Language: Английский

Citations

0
Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy DOI Creative Commons

Jingchao He,

Guangtian Wang, Yongfang Zhou

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.

Language: Английский

Citations

0
Isoliensinine activated the Nrf2/GPX4 pathway to inhibit glutamate‐induced ferroptosis in HT‐22 cells DOI
Hui‐Zhi Long,

Feng-jiao Li,

Lichen Gao

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(9)

Published: Aug. 20, 2024

Abstract Isoliensinine (ISO), a natural compound, is bibenzyl isoquinoline alkaloid monomer in lotus seed, which has strong antioxidant and free radical scavenging activities. The oxidative toxicity caused by glutamic acid overdose one of the important mechanisms nerve cell injury, related to ferroptosis. This study aims establish glutamate‐induced injury model mouse hippocampal neurons HT‐22 cells, investigate protective effect ISO on neurotoxicity cells. results showed that inhibited ferroptosis neuronal cells through nuclear factor E2‐related 2/glutathione peroxidase 4 (Nrf2/GPX4) signaling pathway. Pretreatment with significantly reduced death. Ferroptosis inhibitors have same effect. decrease mitochondrial membrane potential detection increase iron content induced glutamate, malondialdehyde reactive oxygen species cytoplasm lipid, protected activities GPx superoxide dismutase enzymes. In addition, WB could induce upregulated expression long‐chain esteryl coA synthase (ACSL4) protein downregulated SLC7A11 GPX4 while prevent abnormal these proteins acid. translocation Nrf2 was increased, downstream heme oxygenase‐1 upregulated. summary, protects from novel mechanism Nrf2/GPX4

Language: Английский

Citations

1
Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics DOI Creative Commons
Peng Liu, Xizhuo Hu, Zhiqiang Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 25, 2024

Resveratrol, a naturally occurring polyphenolic compound, has captivated the scientific community with its promising therapeutic potential across spectrum of diseases. This review explores complex role resveratrol in modulating ferroptosis, newly identified form programmed cell death, and implications for managing cardiovascular cerebrovascular disorders, cancer, other conditions. Ferroptosis is intricately linked to pathogenesis diverse diseases, exerting multifaceted effects on this process. It mitigates ferroptosis by lipid peroxidation, iron accumulation, engaging specific cellular receptors, thereby manifesting profound benefits conditions, as well oncological settings. Moreover, resveratrol's capacity either suppress or induce through modulation signaling pathways, including Sirt1 Nrf2, unveils novel avenues. Despite limited bioavailability, advancements molecular modification drug delivery optimization have amplified clinical utility. Future investigations are poised unravel comprehensive mechanisms underpinning action expand repertoire. We hope could furnish detailed insight into exploration regulation prospects.

Language: Английский

Citations

0