A future avenue of treatment ulcerative colitis targeting macrophage polarization: A phytochemical Application DOI Creative Commons

Nishant Kumar Saurabh,

Mohd Mabood Khan, Annet Kirabo

et al.

Crohn s & Colitis 360, Journal Year: 2024, Volume and Issue: 6(4)

Published: Oct. 1, 2024

Abstract Background Ulcerative colitis (UC) is a prevalent inflammatory bowel disease primarily impacting the mucosa of colon. It characterized by recurring and incurable symptoms causes immense suffering significant economic burden due to limited treatment options. Typical UC include diarrhea, alterations in patterns, bleeding from rectum, rectal pain or urgency, anemia, tiredness. Therefore, developing novel effective strategies for imperative. Purpose This review aimed explain how macrophage polarization contributes development compiled information on natural compounds with promising therapeutic potential that can target phenotype shed light its mode action. Results The phenotypic alteration macrophages profoundly affects UC, these cells are essential preserving intestinal immunological homeostasis. Evidence research suggests one method prevention therapy guide toward M2 phenotype. Phytochemicals, which extracted plants, possess wide array biological activities. For example: Ginsenoside Rg1 emerges as crucial regulator polarization, promoting while inhibiting M1 Notably, their low toxicity high effectiveness render them candidates interventions. These have demonstrated encouraging protective effects against inflammation Conclusions Exploring phytochemicals avenue targeting presents an innovative approach treating UC.

Language: Английский

Hypericin impedes M2 macrophage polarization and protects against Hepatocellular carcinoma DOI

X. Y. Wen,

Xianling Wang, Qing Yao

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 181, P. 160 - 168

Published: March 29, 2025

Language: Английский

Citations

0
Ginsenoside RB1 Influences Macrophage–DPSC Interactions in Inflammatory Conditions DOI Creative Commons
Wenlan Li,

Yuting Wang,

Wenli Mu

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Unresolved inflammation and tissue destruction are supposed to underlie the failure of dental pulp repair. As crucial regulators injury response, stem cells (DPSCs) play a key role in repair regeneration. M2 macrophages have been demonstrated induce osteogenic/odontogenic differentiation DPSCs. Ginsenoside Rb1 (GRb1) is major component ginseng manifested an anti-inflammatory by promoting M1 macrophage polarised into inflammatory disease. However, whether GRb1 facilitates odontogenic DPSCs via polarisation under conditions has yet be established.

Language: Английский

Citations

3
Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities DOI Creative Commons

Wen-Zhe Nie,

Yalan Wang,

Xinlu Tian

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4193 - 4193

Published: Sept. 4, 2024

The emergence of natural products has provided extremely valuable references for the treatment various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is most abundant member cucurbitin family exhibits wide range biological activities, including anti-inflammatory, anti-cancer, even agricultural applications. Due to its high toxicity narrow therapeutic window, structural modification dosage form development are necessary address these issues with cucurbitacin B. This paper reviews recent research progress in pharmacological action, modification, application review aims enhance understanding advancements this field provide constructive suggestions further on

Language: Английский

Citations

1
Xanthohumol inhibits osteosarcoma proliferation, migration, and invasion via EFEMP1/PI3K/AKT axis DOI Creative Commons
Yun Wang, Lei Yan, Ruoqi Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Abstract Background Osteosarcoma (OS) is a tumor of bone. Xanthohumol (XN) has been found to have antitumor effects. However, it not known whether XN can prevent the development OS. Method The malignant phenotypes OS cell lines were evaluated using CCK-8, clone-formation, EdU, Transwell, and wound-healing assays. molecular mechanism action was investigated by transcriptome sequencing. mRNA levels in cells examined q-PCR protein western blotting immunofluorescence, while Ki-67 PCNA tumors assessed immunohistochemistry. Results dose-dependently blocked proliferation, migration, invasion lines. Transcriptome sequencing revealed that EFEMP1 expression significantly reduced after treatment, which shown rescue assays tumor-suppressive effect. Reduced EFEMP1/PI3K/AKT axis treatment demonstrated blotting. Conclusion blocks tumorigenic behavior inhibition axis.

Language: Английский

Citations

0
A future avenue of treatment ulcerative colitis targeting macrophage polarization: A phytochemical Application DOI Creative Commons

Nishant Kumar Saurabh,

Mohd Mabood Khan, Annet Kirabo

et al.

Crohn s & Colitis 360, Journal Year: 2024, Volume and Issue: 6(4)

Published: Oct. 1, 2024

Abstract Background Ulcerative colitis (UC) is a prevalent inflammatory bowel disease primarily impacting the mucosa of colon. It characterized by recurring and incurable symptoms causes immense suffering significant economic burden due to limited treatment options. Typical UC include diarrhea, alterations in patterns, bleeding from rectum, rectal pain or urgency, anemia, tiredness. Therefore, developing novel effective strategies for imperative. Purpose This review aimed explain how macrophage polarization contributes development compiled information on natural compounds with promising therapeutic potential that can target phenotype shed light its mode action. Results The phenotypic alteration macrophages profoundly affects UC, these cells are essential preserving intestinal immunological homeostasis. Evidence research suggests one method prevention therapy guide toward M2 phenotype. Phytochemicals, which extracted plants, possess wide array biological activities. For example: Ginsenoside Rg1 emerges as crucial regulator polarization, promoting while inhibiting M1 Notably, their low toxicity high effectiveness render them candidates interventions. These have demonstrated encouraging protective effects against inflammation Conclusions Exploring phytochemicals avenue targeting presents an innovative approach treating UC.

Language: Английский

Citations

0