Epigenetic modulation of autophagy pathway by small molecules in colorectal cancer: a systematic review DOI Creative Commons
Mozhdeh Zamani, Farima Safari, Morvarid Siri

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(10)

Published: Oct. 23, 2024

Colorectal cancer (CRC) remains a global health challenge with limited treatment success due to drug resistance. Recent research highlights the potential of small molecules modulate CRC by targeting epigenetics or autophagy pathways. This systematic review explores epigenetic effect on in CRC, aiming identify novel therapeutic strategies. Following PRISMA guidelines, we systematically reviewed 508 studies from PubMed, Scopus, and Web Science databases until August 13, 2023. Eight met inclusion criteria, examining role as modulators (Histone acetylation/deacetylation, DNA methylation/demethylation gene expression regulation miRNAs) influencing pathway CRC. The encompassed vitro animal model vivo studies. Small exhibited diverse effects For instance, panobinostat promoted leading cell death, while aspirin inhibited flux, reducing aspirin-mediated death. modulation various differently affects their anticancer effect, which underscores complexity interventions. Understanding intricate dynamics among molecules, modifications, is crucial for developing targeted Considering dual tumorigenesis tumor suppression, administration these may affect fate response resistance based pathway. Therefore, recognition mechanism contribute deciding how prescribe them better treatment.

Language: Английский

Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective DOI Creative Commons
Karen Vanessa Fernandez-Muñoz, Ángel Sánchez‐Barrera, Marco Antonio Meraz‐Ríos

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 326 - 326

Published: Feb. 24, 2025

Colorectal cancer (CRC) is one of the deadliest neoplasia. Intrinsic or acquired resistance main cause failure therapy regimens that leads to relapse and death in CRC patients. The widely used chemotherapeutic agent 5-fluorouracil (5-FU) remains mainstay for therapeutic combinations. Unfortunately, side effects are frequent events compromise success these therapies; dysregulation enzymes regulate 5-FU metabolism increases expression activity efflux pumps. Additional tumor cell adaptations such as epithelial–mesenchymal transition (EMT), autophagy shaping microenvironment, inflammation contribute chemoresistance. Finding new strategies alternatives enhance conventional chemotherapies has become necessary. Recently, study natural compounds been gaining strength an alternative chemotherapeutics different cancers. Curcumin, trimethylglycine, resveratrol, artemisinin, some helminth-derived molecules, among others, studied context CRC. This review discusses benefits, mechanisms, advances, dark currently evaluated treatment. We also analyzed landscape non-conventional their underlying mechanisms action, which could, short term, provide fundamental knowledge harness anti-tumor allow them be adjuvant therapies.

Language: Английский

Citations

2
Targeting sirtuins for cancer therapy: epigenetics modifications and beyond DOI Creative Commons
Hui Shen,

Xinyi Qi,

Yue Hu

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(17), P. 6726 - 6767

Published: Jan. 1, 2024

Sirtuins (SIRTs) are well-known as nicotinic adenine dinucleotide

Language: Английский

Citations

9
The Interplay Between Autophagy and Apoptosis in the Mechanisms of Action of Stilbenes in Cancer Cells DOI Creative Commons
Kamila Siedlecka-Kroplewska, Zbigniew Kmieć, Michał A. Żmijewski

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 339 - 339

Published: March 13, 2025

Plant-based stilbenes are low-molecular-weight polyphenolic compounds that exhibit anti-oxidant, anti-microbial, anti-fungal, anti-inflammatory, anti-diabetic, cardioprotective, neuroprotective, and anti-cancer activities. They phytoalexins produced in diverse plant species response to stress, such as fungal bacterial infections or excessive UV irradiation. Plant-derived dietary products containing common components of the human diet. Stilbenes appear be promising chemopreventive chemotherapeutic agents. Accumulating evidence indicates able trigger both apoptotic autophagic molecular pathways many cancer cell lines. Of note, crosstalk between autophagy apoptosis under cellular stress conditions determines fate. The relationship is complex depends on context, e.g., type level. Apoptosis a regulated death, whereas may act pro-survival pro-death mechanism depending context. interplay have an important impact chemotherapy efficiency. This review focuses vitro effects different lines concerning apoptosis.

Language: Английский

Citations

0
Potential for Resveratrol to Combine with Hydrogel for Photodynamic Therapy against Bacteria and Cancer—A Review DOI Creative Commons
Siukan Law, Wai‐Ching Liu, Christy Wing Sum Tong

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2095 - 2095

Published: Sept. 13, 2024

Bacterial infections and cancers are important issues in public health around the world. Currently, Western medicine is most suitable approach when dealing with these issues. "Antibiotics" "Corticosteroids" medicines used for bacterial infection. "Chemotherapy drugs", "surgery", "radiotherapy" common techniques to treat cancer. These conventional treatments many side effects. PDT a non-invasive effective therapy infection cancer diseases.

Language: Английский

Citations

1
Epigenetic modulation of autophagy pathway by small molecules in colorectal cancer: a systematic review DOI Creative Commons
Mozhdeh Zamani, Farima Safari, Morvarid Siri

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(10)

Published: Oct. 23, 2024

Colorectal cancer (CRC) remains a global health challenge with limited treatment success due to drug resistance. Recent research highlights the potential of small molecules modulate CRC by targeting epigenetics or autophagy pathways. This systematic review explores epigenetic effect on in CRC, aiming identify novel therapeutic strategies. Following PRISMA guidelines, we systematically reviewed 508 studies from PubMed, Scopus, and Web Science databases until August 13, 2023. Eight met inclusion criteria, examining role as modulators (Histone acetylation/deacetylation, DNA methylation/demethylation gene expression regulation miRNAs) influencing pathway CRC. The encompassed vitro animal model vivo studies. Small exhibited diverse effects For instance, panobinostat promoted leading cell death, while aspirin inhibited flux, reducing aspirin-mediated death. modulation various differently affects their anticancer effect, which underscores complexity interventions. Understanding intricate dynamics among molecules, modifications, is crucial for developing targeted Considering dual tumorigenesis tumor suppression, administration these may affect fate response resistance based pathway. Therefore, recognition mechanism contribute deciding how prescribe them better treatment.

Language: Английский

Citations

0