Celastrol combined with curcumin inhibits proliferation and causes cell death in nasopharyngeal carcinoma CNE1 cell line by inducing ferroptosis DOI Creative Commons
Tao Feng,

Yinjun Luo,

Xin Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract Background Nasopharyngeal carcinoma (NPC) is a highly invasive form of head and neck cancer that arises from nasopharyngeal epithelial cells. The treatment advanced NPC with radiotherapy presents significant challenges due to cellular resistance, which has spurred interest in natural small molecule drugs. Celastrol curcumin, both derived plants, have exhibited anti-tumor properties. However, the clinical development celastrol hindered by its low bioavailability associated toxic side effects, while although non-toxic, also suffers limited bioavailability. combination drugs fundamental principle traditional Chinese medicine, as it enhances therapeutic efficacy reducing toxicity, suggesting potential synergistic use curcumin. Furthermore, ferroptosis crucial for tumor cell death. Consequently, our study aims investigate whether curcumin can induce cells assess antiproliferative effects. Methods Human lines were used vitro analysis. CCK8 was evaluate effect different concentrations curmin on viability human CNE1 line. Mitochondrial reactive oxygen species mitochondrial membrane detected determine oxidative stress function. Western blot detect apoptosis, autophagy ferritin-related proteins expression. Results more pronounced Following these compounds, mitochondria generated substantial amounts species, resulting impaired Moreover, death induced found be independent instead, correlated increased autophagy, enhanced fission, induction ferroptosis. Conclusion Low doses combined greater inhibition growth compared alone. This therapy likely attributable effects fission

Language: Английский

Curcumin and nanodelivery systems: New directions for targeted therapy and diagnosis of breast cancer DOI Open Access
Ruhong Zhou,

Jie Gong,

Xianguang Deng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117404 - 117404

Published: Sept. 21, 2024

Language: Английский

Citations

13
New advances of natural products in non-small cell lung cancer: from mechanisms to therapies DOI

Yuening Yang,

Haolei Wang,

Qianqian Xue

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119636 - 119636

Published: March 1, 2025

Language: Английский

Citations

1
Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites DOI Creative Commons
Deng Wen-xin,

Xiaojian Xiong,

Mingyang Lu

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 12, 2024

Language: Английский

Citations

5
Emerging drivers of female bladder cancer: a pathway to precision prevention and treatment DOI Creative Commons

Jianbin Zhang,

Haixia Jia,

Hui Han

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 14, 2025

Purpose Bladder cancer is a public health concern, with smoking and occupational exposure being major risk factors. However, specific risks in women, particularly hormonal, lifestyle, environmental factors, are underexplored. This study aimed to assess these factors focusing on smoking, exposure, recurrent urinary tract infections (UTIs), body mass index (BMI), menopausal status, family history of cancer. Materials methods retrospective cohort included 850 women diagnosed bladder (2018–2023) age-matched controls. Data UTIs, BMI, were collected from medical records: multivariate logistic regression propensity score matching identified independent Subgroup analysis explored interactions between status other Results Smoking (OR = 2.15, p 0.002), 1.89, 0.007), UTIs 1.72, 0.013) significant post-menopausal women. Menopausal amplified the effects but was not an predictor. BMI showed no associations. Conclusion Smoking, key for especially highlighting need targeted prevention strategies.

Language: Английский

Citations

0
Synthesis of Curcumin/Chia Gel Nanohybrids: Assessment of Inflammation-Related Genes Expression on Human Mesenchymal Stem Cells DOI
Abdulrahman S. Alharthi, Maha H. Alhussain, Jegan Athinarayanan

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106376 - 106376

Published: March 1, 2025

Language: Английский

Citations

0
Preclinical and Molecular Docking Insights into the Chemopreventive Role of Fenugreek Seed Extract in a Murine Model of Colorectal Cancer DOI Creative Commons
Arif Khan, Khaled S. Allemailem,

Arwa Essa Alradhi

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 490 - 490

Published: March 28, 2025

Background/Objectives: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, necessitating the development effective preventive strategies. Fenugreek (Trigonella foenum-graecum) possesses well-documented pharmacological properties; however, its chemopreventive potential in colorectal unexplored. This study evaluates efficacy methanolic fenugreek seed extract (FSE) an azoxymethane (AOM)-induced murine model, focusing on modulation oxidative stress, regulation biomarkers, induction apoptosis, and maintenance epithelial integrity. Methods: FSE was extracted using cold maceration (yield: 24%) analyzed by gas chromatography–mass spectrometry (GC-MS), identifying 13 bioactive compounds, including benzene, 1,3-dimethyl-; 1,3-cyclopentadiene, 5-(1-methylethylidene)-; o-Xylene; benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-; 1,2,3-trimethyl-. All compounds identified were matched with NIST library high confidence. Molecular docking used to assess interactions bioactives E-cadherin–β-catenin complexes. Swiss albino mice received pre-treatment before AOM continued this treatment three times weekly for 21 weeks. Key assessments included survival analysis, body weight changes, serum biomarker levels (GGT, 5′-NT, LDH), antioxidant enzyme activities (SOD, CAT, GPx1, MDA), reactive oxygen species (ROS) quantification, apoptosis detection via flow cytometry, immunofluorescence-based evaluation E-cadherin dynamics. Results: improved rates, mitigated AOM-induced loss, dose-dependently reduced levels. Antioxidant activity restored, while MDA declined. A dose-dependent increase ROS facilitated as confirmed cytometry (16.7% low-dose group 34.5% high-dose group). Immunofluorescence studies revealed that FSE-mediated restoration localization counteracted disruptions. Conclusions: exhibits potent against CRC modulating regulating key inducing restoring These findings support further investigations into clinical relevance prevention.

Language: Английский

Citations

0
Molecular Understanding and Pharmacological Potency of Plant-Derived Compounds in Colorectal Cancer (CRC): A Critical Analysis and Future Perspectives DOI

Vaagdevi Mukkavilli,

Gnanasekaran Ramakrishnan, G. Koteswara Reddy

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(3), P. 1777 - 1795

Published: July 4, 2024

Language: Английский

Citations

2
Celastrol combined with curcumin inhibits proliferation and causes cell death in nasopharyngeal carcinoma CNE1 cell line by inducing ferroptosis DOI Creative Commons
Tao Feng,

Yinjun Luo,

Xin Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract Background Nasopharyngeal carcinoma (NPC) is a highly invasive form of head and neck cancer that arises from nasopharyngeal epithelial cells. The treatment advanced NPC with radiotherapy presents significant challenges due to cellular resistance, which has spurred interest in natural small molecule drugs. Celastrol curcumin, both derived plants, have exhibited anti-tumor properties. However, the clinical development celastrol hindered by its low bioavailability associated toxic side effects, while although non-toxic, also suffers limited bioavailability. combination drugs fundamental principle traditional Chinese medicine, as it enhances therapeutic efficacy reducing toxicity, suggesting potential synergistic use curcumin. Furthermore, ferroptosis crucial for tumor cell death. Consequently, our study aims investigate whether curcumin can induce cells assess antiproliferative effects. Methods Human lines were used vitro analysis. CCK8 was evaluate effect different concentrations curmin on viability human CNE1 line. Mitochondrial reactive oxygen species mitochondrial membrane detected determine oxidative stress function. Western blot detect apoptosis, autophagy ferritin-related proteins expression. Results more pronounced Following these compounds, mitochondria generated substantial amounts species, resulting impaired Moreover, death induced found be independent instead, correlated increased autophagy, enhanced fission, induction ferroptosis. Conclusion Low doses combined greater inhibition growth compared alone. This therapy likely attributable effects fission

Language: Английский

Citations

0