Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization DOI Creative Commons
Yang Fu, Xinwang Duan, Wei Zhou

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 21, 2024

Previous clinical studies have suggested an increased risk of tumor development in patients with pulmonary arterial hypertension (PAH). However, it remains unclear whether there is a causal relationship between PAH and occurrence. This study investigates the link cancer from genetic perspective using Mendelian randomization (MR). Genome-wide association (GWAS) summary data for various common types were obtained GWAS Catalog. Single nucleotide polymorphisms (SNPs) significantly associated at genome-wide significance threshold (P < 1 × 10−6) selected as instrumental variables (IVs). Inverse-variance weighted (IVW) was used primary method MR analysis, sensitivity analyses including tests heterogeneity horizontal pleiotropy. The results IVW analysis indicate that genetically proxied liver [odd ratio (OR) 1.11, 95% confidence interval (CI) 1.01–1.22, P = 0.025), while showing no significant other tumors (thyroid cancer: OR 0.95, CI 0.86–1.06, 0.360; lung 0.90–1.01, 0.129; gastric 0.97, 0.93–1.02, 0.243; colorectal 1.01, 0.98–1.05, 0.412). Except examining effect on 0.049), remaining displayed > 0.05). Additionally, MR-Egger intercept test did not find evidence pleiotropy highlights may serve potential factor this cancer. Future research should aim to elucidate biological mechanisms play explore early interventions could mitigate vulnerable population.

Language: Английский

Management of pulmonary hypertension in special conditions DOI Creative Commons
Ioana R. Preston, Luke Howard, David Langleben

et al.

European Respiratory Journal, Journal Year: 2024, Volume and Issue: 64(4), P. 2401180 - 2401180

Published: Aug. 29, 2024

Care of pulmonary hypertension (PH) patients in special situations requires insightful knowledge the pathophysiology cardiopulmonary system and close interaction with different specialists, depending on situation. The role this task force was to gather about five conditions that PH may be faced with. These are 1) perioperative care; 2) management pregnancy; 3) medication adherence; 4) palliative 5) influence climate PH. Many these aspects have not been covered by previous World Symposia Pulmonary Hypertension. All above highly affected psychological, geographical socioeconomic factors, share need for adequate healthcare provision. identified significant gaps information research areas. current recommendations based detailed literature search expert opinion. calls further studies better understand address circumstances encounter.

Language: Английский

Citations

5
Burden of Pulmonary Arterial Hypertension in China from 1990 to 2021, with Projections to 2050: An Analysis of Data from the Global Burden of Disease Study 2021 DOI Creative Commons

Shuoshuo Wei,

Yonghui Han, Min Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Background Pulmonary arterial hypertension (PAH) is a severe condition with high morbidity and mortality, yet its epidemiology in China remains poorly understood. This study aims to assess the burden of PAH from 1990 2021 project trends 2050, providing insights for effective management prevention strategies. Method Data Global Burden Disease (GBD) Study were analyzed, focusing exclusively on PAH. Key metrics included incidence, prevalence, disability-adjusted life years (DALYs), along their corresponding age-standardized rates (ASRs). Average annual percent changes (AAPCs) calculated using joinpoint regression analysis, Bayesian age-period-cohort model was employed through 2050. Results In 2021, there 41,135 estimated prevalent cases (95% UI: 32,838.91 51,357.25) China, an prevalence rate (ASPR) 2.24 per 100,000. Females accounted approximately 58% cases. caused 7,318 deaths 4,835.72 9,075.75; 3,683 males, 3,635 females), death (ASDR) 0.42 From ASPR increased slightly 2.07 1.68 2.54) 1.81 2.75), while ASDR decreased 0.61 0.46 0.83) 0.28 0.51). Projections suggest declining both ASDR, although overall expected rise over next 30 years. Conclusion imposes significant disease particularly among women older adults. These findings highlight urgent need enhance diagnostic capabilities develop improved treatment strategies address this challenging Chinese population.

Language: Английский

Citations

0
Association between hydrocarbon exposure and risk of stroke: a systematic literature review DOI Creative Commons
Muhammed Shabil, Abhay Gaidhane,

Nasir Vadia

et al.

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Abstract Background Hydrocarbon exposure, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), is increasingly linked to vascular dysfunction stroke, a leading cause of morbidity mortality globally. Common in occupational environmental contexts, induce oxidative stress, systemic inflammation, endothelial dysfunction, disrupting health. This systematic review examines the association between hydrocarbon exposure emphasizing specific metabolites their cerebrovascular effects. Methods A comprehensive search across PubMed, Embase, Web Science was conducted through December 10 2024, identifying observational studies exploring stroke risk. Studies meeting predefined inclusion criteria, excluding those with major methodological flaws, were synthesized narratively. Variations types, population demographics, outcomes considered. Results Six studies, five cross-sectional one retrospective cohort, sample sizes ranging from 5,537 283,666 participants, demonstrated significant associations Key findings revealed strong for like 1-hydroxynaphthalene (OR: 1.89; 95% CI: 1.62–2.20) 2-hydroxyfluorene 1.94; 1.66–2.26). However, variability noted, attributed differences study design, levels, populations studied. Conclusion highlights complex relationship risk, some indicating others reporting inconsistencies. Standardized, large-scale research essential clarify this relationship, identify high-risk populations, guide public health strategies mitigate prevent stroke. Clinical trial number Not applicable.

Language: Английский

Citations

0
Infection and pulmonary vascular diseases consortium: United against a global health challenge DOI Creative Commons
Suellen Darc Oliveira, Sharilyn Almodóvar, Ghazwan Butrous

et al.

Pulmonary Circulation, Journal Year: 2024, Volume and Issue: 14(4)

Published: Oct. 1, 2024

Abstract Leveraging the potential of virtual platforms in post‐COVID‐19 era, Infection and Pulmonary Vascular Diseases Consortium (iPVDc), with support Research Institute (PVRI), launched a globally accessible educational program to highlight top‐notch research on inflammation infectious diseases affecting lung vasculature. This innovative series has already successfully brought together distinguished investigators across five continents – Asia, Europe, South North America, Africa. Moreover, these open global forums have contributed comprehensive understanding complex interplay among immunology, inflammation, infection, cardiopulmonary health, especially concerning pulmonary hypertension related disorders. These enlightening discussions not only heightened awareness about impact various pathogenic microorganisms, including fungi, parasites, viruses, onset development vascular but also cast spotlight co‐infections neglected illnesses like schistosomiasis ‐ disease that continues impose heavy socioeconomic burden numerous regions worldwide. Thus, overall goal this review article is present most recent breakthroughs from PVDs as well bring light scientific insights 2023 iPVDc/PVRI symposium series, shaping our crucial health issues more than ever interconnected world.

Language: Английский

Citations

2
Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization DOI Creative Commons
Yang Fu, Xinwang Duan, Wei Zhou

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 21, 2024

Previous clinical studies have suggested an increased risk of tumor development in patients with pulmonary arterial hypertension (PAH). However, it remains unclear whether there is a causal relationship between PAH and occurrence. This study investigates the link cancer from genetic perspective using Mendelian randomization (MR). Genome-wide association (GWAS) summary data for various common types were obtained GWAS Catalog. Single nucleotide polymorphisms (SNPs) significantly associated at genome-wide significance threshold (P < 1 × 10−6) selected as instrumental variables (IVs). Inverse-variance weighted (IVW) was used primary method MR analysis, sensitivity analyses including tests heterogeneity horizontal pleiotropy. The results IVW analysis indicate that genetically proxied liver [odd ratio (OR) 1.11, 95% confidence interval (CI) 1.01–1.22, P = 0.025), while showing no significant other tumors (thyroid cancer: OR 0.95, CI 0.86–1.06, 0.360; lung 0.90–1.01, 0.129; gastric 0.97, 0.93–1.02, 0.243; colorectal 1.01, 0.98–1.05, 0.412). Except examining effect on 0.049), remaining displayed > 0.05). Additionally, MR-Egger intercept test did not find evidence pleiotropy highlights may serve potential factor this cancer. Future research should aim to elucidate biological mechanisms play explore early interventions could mitigate vulnerable population.

Language: Английский

Citations

0