LC-HRMS and NMR studies for the characterization of degradation impurities of ubrogepant along with the in silico approaches for the prediction of degradation and toxicity

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 243, P. 116117 - 116117

Published: March 19, 2024

Language: Английский

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Forced Degradation Study of an Anti‐Diabetic Drug Imeglimin: Impurity Profiling and Structure Elucidation Using LC‐Q‐ToF‐MS/MS and NMR

Rapid Communications in Mass Spectrometry, Journal Year: 2024, Volume and Issue: 39(5)

Published: Dec. 10, 2024

The present study aims to establish structures of the degradation products an anti-diabetic drug, Imeglimin (IMG) approved for treatment type 2 diabetes mellitus in year 2021. Degradation pathways are proposed along with silico toxicity assessments observed (DPs) drug.

Language: Английский

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Separation and characterization of degradation impurities of upadacitinib by liquid chromatography and high resolution mass spectrometry

Journal of Chromatography B, Journal Year: 2024, Volume and Issue: 1247, P. 124319 - 124319

Published: Sept. 13, 2024

Language: Английский

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Comprehensive Chromatographic Analysis of Belumosudil and its Degradation Products: Development, Validation, and In Silico Toxicity Assessment

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38369 - e38369

Published: Sept. 24, 2024

Language: Английский

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