The effect of SARS‐CoV‐2 infection on cardiac function in post‐COVID‐19 survivors: A systematic review and meta‐analysis

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Nov. 19, 2022

The longitudinal trajectories of cardiac structure and function following SARS-CoV-2 infection are unclear. Therefore, this meta-analysis aims to elucidate the effect on in coronavirus disease 2019 (COVID-19) survivors after recovery. PubMed/MEDLINE, CENTRAL, EMBASE were systematically searched for articles published up 1st August 2022. A systematic review performed calculate pooled effects size 95% confidence interval each outcome. total 21 studies including 2394 individuals (1436 post-COVID-19 cases 958 controls) included present meta-analysis. analyses compared with control groups showed a significant association between reduced left ventricular ejection fraction (LV EF), LV end-diastolic volume EDV), stroke SV), mitral annular plane systolic excursion (MAPSE), global strain, right EF (RV RV EDV, ESV, SV, tricuspid excursion, increased mass. Subgroup analysis based severity COVID-19 acute phase subsequent chronic outcomes revealed that EF, MAPSE, ESV only decreased patients history intensive care unit admission. Cardiac impairment persisted recovered even 1 year. Future warranted determine biological mechanisms underlying long-term cardiovascular consequences COVID-19.

Language: Английский

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Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 14, 2024

Abstract Background The relationship between COVID-19 infection and a possible increased likelihood of older adults developing new-onset dementia (NOD) remains elusive. Methods A thorough search was performed across several databases including MEDLINE/PubMed, PsycINFO, Scopus, medRxiv, PQDT Global for studies published in English from January 2020 to December 2023. Only original investigations exploring the link NOD were selected inclusion. We assessed risk NOD, using Risk Ratio (RR) measurement. Control groups categorized as: (i) non-COVID cohort with other respiratory infections [control group (C1)]; (ii) otherwise unspecified health status (C2)]. Follow-up periods divided into intervals 3, 6, 12, 24 months post-COVID. Results 11 (involving 939,824 post-COVID-19 survivors 6,765,117 controls) included review. Across median observation period 12 post-COVID, overall incidence about 1.82% COVID-infected group, compared 0.35% non-COVID-infected group. pooled meta-analysis showed significantly among adult non-COVID-19 controls (RR = 1.58, 95% CI 1.21–2.08). Similar risks observed subgroup analyses restricted an observational 1.56, 1.21–2.01), as well five that employed propensity score matching sufficiently effectively control multiple confounding covariates 1.46, 1.10–1.94). C1 shared comparably (overall RR 1.13, 0.92–1.38). Discussion Under normal circumstances, we believe is likely be factor over time. While due appears similar associated infections, it warrants necessitates investigation longer observations.

Language: Английский

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The effectiveness of community ageing in place, advancing better living for elders as a biobehavioural environmental approach for disability among low-income older adults: a systematic review and meta-analysis

Age and Ageing, Journal Year: 2023, Volume and Issue: 52(4)

Published: April 1, 2023

Abstract Background community ageing in place, advancing better living for elders (CAPABLE), which is a biobehavioural environmental approach by addressing individual capacities and the home environment, aims to reduce impact of disability among low-income older adults. Objective this meta-analysis elucidate efficacy CAPABLE program on related outcomes Methods systematic search MEDLINE/PubMed, CINAHL EMBASE was conducted articles published up August 2022. A review were performed calculate pooled effect sizes safety hazards, activities daily (ADLs), instrumental ADLs (IADLs), depression, falls efficacy, pain quality life. Results seven studies involving 2,921 adults (1,117 as group 1,804 served control) with an average age ranging from 65 79 included present meta-analysis. Pre–post analyses showed that significantly associated lower ADLs, IADLs, Additionally, there statistically significant associations between improvements IADLs life compared controls. Conclusion intervention may be promising strategy health disparities, limitations, improve community-dwelling who suffer disabilities both person environment.

Language: Английский

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Association of Pulmonary Involvement at Baseline with Exercise Intolerance and Worse Physical Functioning 8 Months Following COVID-19 Pneumonia

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 475 - 475

Published: Jan. 13, 2025

Objectives: We aimed to describe the cardiopulmonary function during exercise and health-related quality of life (HRQoL) in patients with a history COVID-19 pneumonia, stratified by chest computed tomography (CT) findings at baseline. Methods: Among 77 consecutive who were discharged from Pulmonology Ward between March 2020 April 2021, 28 (mean age 54.3 ± 8.6 years, 8 females) agreed participate current study. The participants analyzed two groups based on pulmonary involvement (PI) baseline CT applying threshold 25%. A consequent artificial intelligence (AI)-guided total opacity score (TOS) was calculated subgroup 22 patients. test (CPET) conducted average 8.4 (±1.9) months after discharge hospital. HRQoL defined using short-form (SF-36) questionnaire. primary outcome intolerance that as peak oxygen uptake (V′O2peak) < 80% predicted. Secondary outcomes ventilatory limitation, breathing reserve 15%, circulatory pulse predicted below 80%, deconditioning, absence limitations. Other secondary included SF-36 domains. Results: In all, 15 had least 25% PI (53.6%) CT. Exercise observed ten (35.7%), six due deconditioning four limitation; none limitation. AI-guided TOS 30.1 24.4% vs. 6.1 4.8% (p 0.001) baseline, 1.7 3.0% 0.2 0.7% (nonsignificant) follow-up high low groups, respectively. physical functioning (PF) domain questionnaire 66.3 19.4 85.0 13.1 respectively = 0.007). domains did not differ significantly groups. inversely correlated V′O2peak (standardized β coefficient −0.436; 95% CI −26.1; −0.7; p 0.040) PF scores −0.654; −41.3; −7.6; 0.006) adjusted for age, sex, body mass index lung diffusion capacity. Conclusions: One-third experienced eight pneumonia. higher associated PF. Notwithstanding, radiological resolved, mainly explained limitation but deconditioning.

Language: Английский

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Impact of coronavirus (COVID-19) pandemic on physical activity levels in different sub-populations of Iranians: a national survey

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

During the COVID-19 pandemic, level of physical activity (PA) has been reported to decrease worldwide. A sedentary lifestyle is widely recognized as a significant risk factor for various diseases, necessitating extensive big data analysis uncover diverse aspects linked pandemic. Therefore, aim this study was investigate impact pandemic on PA levels across population subsets in Iran and identify barriers during fifth wave outbreak. Data from 7810 individuals (50.8% male, 54.8% married, 69.6% 18–49 years) were collected using standardized questionnaire comprising demographic details, high, moderate, low PA, daily time, at home, PA. The distributed online via social platforms such Telegram, WhatsApp, Instagram. obtained analyzed Chi-Square goodness-of-fit test significance α < 0.05. there number days/week dedicated well reduction duration each session compared pre-pandemic (p 0.001). Conversely, particularly exceeding 5 h, significantly increased post-outbreak Notably, lack appropriate space time constraints identified primary In nationally representative study, findings underscore substantial decline sub-populations an increase behaviors crisis.

Language: Английский

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Disease-Associated Test Procedures and Medical Exercise Therapy for Internal Diseases

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 221 - 237

Published: Jan. 1, 2025

Language: Английский

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Management of SARS-CoV-2 Infection-Clinical Practice Guidelines of the Polish Association of Epidemiologists and Infectiologists, for 2025

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2305 - 2305

Published: March 27, 2025

The first Polish recommendations for the management of COVID-19 were published by Society Epidemiologists and Infectiologists (PTEiLChZ) on 31 March 2020, last three years ago. emergence new SARS-CoV-2 variants, a different course disease, as well knowledge about therapies vaccines, requires updating diagnostic, therapeutic, prophylactic guidelines. Despite reduction in threat associated with COVID-19, there is risk another epidemic caused coronaviruses, which was an additional reason developing version In preparing these recommendations, Delphi method used, reaching consensus after survey cycles. Compared to 2022 version, names individual stages disease have been changed, adapting them realities clinical practice, attention paid differences observed immunosuppressed patients children. Some previously recommended drugs discontinued, including monoclonal antibodies. addition, general principles vaccination presented, issues related post-COVID syndrome.

Language: Английский

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COVID-19 Vaccine Effectiveness and Risk Factors of Booster Failure in 480,000 Patients with Diabetes Mellitus: A Population-Based Cohort Study

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 979 - 979

Published: April 24, 2025

To investigate the real-world effectiveness of COVID-19 vaccines in a large cohort patients with diabetes mellitus (DM), we analyzed all >18-year-old registered Brazilian nationwide surveillance database between February 2020 and 2023. The primary outcome interest was vaccine against death, evaluated using multivariate logistic regression models. Among 2,131,089 SIVEP-Gripe, 482,677 (22.6%) had DM. After adjusting for covariates, DM higher risk death than those without comorbidities (adjusted odds ratio [aOR] = 1.43, 95% CI, 1.39–1.47). For (72.7%, 70.5–74.7) (73.4%, 68.2–76.7), similar after booster dose. However, it reduced associated other (60.5%; 57.5–63.2). strongest factor failure omicron variant (aOR 27.8, 19.9–40.1). Our study revealed that provided robust protection individuals our findings underscore need to update develop tailored strategies diabetes, especially additional underlying conditions.

Language: Английский

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Effects of physical activity on the severity of illness and mortality in COVID-19 patients: A systematic review and meta-analysis

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 8, 2022

Purpose: This systematic review and meta-analysis investigated the association between Physical activity (PA) before Coronavirus Disease 2019 (COVID-19) infection severity of illness mortality in COVID-19 patients. Methods: A comprehensive search was undertaken to identify retrospective nonrandomized controlled trial studies comparing among patients who had previously reported their participation PA with those not. The databases searched were PubMed, Cochrane Library, Scopus, Science Direct, EMBASE, OPENGREY.EU, ClinicalTrials.gov. risk bias assessed using Newcastle-Ottawa Scale. random-effects model used for determining pairwise meta-analyses. protocol registered PROSPERO (CRD42021262548). Results: Eighteen met inclusion criteria (5 cross-sectional, 12 cohort, 1 case-control studies). All 618 680 subjects adults. significantly decreased death (odds ratio [OR] 0.34; 95% confidence interval [CI], 0.19-0.62; p < 0.001) severe outcomes (OR 0.60; CI, 0.48-0.76; 0.001). Subgroup analysis showed that ≥150 min/wk at a moderate intensity or ≥75 vigorous reduced risks mortality. Vigorous risk, whereas Conclusion: might reduce patients, especially ≥ 150 activity. However, careful interpretations should be considered due difference patterns definitions included studies. finding implies engaging regular PA, even different patterns, has beneficial effects on

Language: Английский

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The effect of SARS-CoV-2 on the development of Parkinson's disease: the role of α-synuclein

Human Cell, Journal Year: 2023, Volume and Issue: 37(1), P. 1 - 8

Published: Sept. 21, 2023

Language: Английский

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