Promising Markers of Inflammatory and Gut Dysbiosis in Patients with Post-COVID-19 Syndrome DOI Open Access
E. A. Sorokina, Alisa Pautova,

Oleg E. Fatuev

et al.

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(6), P. 971 - 971

Published: June 8, 2023

Post-COVID-19 syndrome is a complex of different symptoms, which results in multisystemic impairment after the suffering from COVID-19 infection. The aim study was to reveal clinical, laboratory, and gut disorders patients with post-COVID-19 (n = 39) before taking part 14-day program rehabilitation. A complete blood count, coagulation test, chemistry, biomarkers, metabolites serum samples, dysbiosis were revealed on day admission rehabilitation, comparison variables healthy volunteers 48) or reference ranges. On discharge, noted an improvement respiratory function, general well-being, mood. At same time, levels some metabolic (4-hydroxybenzoic, succinic, fumaric acids) inflammatory (interleukin-6) variables, increased admission, did not reach level people during rehabilitation program. Taxonomy disbalance observed patients’ feces, namely, high total bacterial mass, decrease number Lactobacillus spp., increase pro-inflammatory microorganisms. authors suggest that should be personalized, considering patient’s state together only baseline but also individual taxonomy microbiota.

Language: Английский

T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID DOI Creative Commons
Renaud Cezar, Lucy Kundura,

Sónia André

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 3, 2024

As about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology so-called long COVID.

Language: Английский

Citations

4
Immune activation and immune-associated neurotoxicity in Long-COVID: A systematic review and meta-analysis of 103 studies comprising 58 cytokines/chemokines/growth factors DOI
Abbas F. Almulla,

Yanin Thipakorn,

Bo Zhou

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 122, P. 75 - 94

Published: Aug. 9, 2024

Language: Английский

Citations

4
Long COVID: Pathophysiological and immunological dynamics DOI
Sandra López‐León, Carol Perelman, Talia Wegman‐Ostrosky

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 585 - 597

Published: Jan. 1, 2025

Language: Английский

Citations

0
Correlation Between Inflammatory Markers and Pathogenic Bacteria in Children’s Winter Respiratory Infections in Xinjiang DOI Creative Commons
Lixia Wang, Wei Wang, Jian Wang

et al.

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 331 - 343

Published: Jan. 1, 2025

Background: This study examines the distribution characteristics of pathogenic bacteria in respiratory infections and their relationship with inflammatory markers to guide clinical drug use.Methods: We selected 120 patients lower tract infection electronic medical record system Xinjiang Provincial People's Hospital from March 2019 2023 for a case-control study.Using Indirect Immunofluorescence Antibody test(IFA), blood routine, C-reactive Protein (CRP), High-sensitivity Protein(hsCRP), we detected nine pathogens (Respiratory syncytial virus; Influenza A B Parainfluenza Adenovirus; Mycoplasma pneumoniae; Chlamydia Legionella pneumophila type 1; Rickettsia Q) all analyzed correlation.The were divided into three groups [Respiratory Syncytial Virus Immunoglobulin M(RSV-IgM) positive group A, M(MP -IgM) B, antibody -negative elevated hsCRP, 40 each].We compared differences platelet count, White Blood Cells(WBC), Neutrophil(NE) among groups.Results: conducted systematic sorting analysis variables exhibiting significant differences.The results multivariate logistic regression indicated that markers, including white cell count (WBC) (OR 3.85, 95% CI: 1.116-1.623),neutrophils (NE) 2.26, 1.091-1.312),high-sensitivity protein (HsCRP) 1.95, 1.068-14.640),lymphocytes 1.30, 1.045-1.134),platelet 1.34, 1.625-2.760),and (CRP) 3.80, 1.232-2.379),were significantly associated presence bacteria.Conclusion: There was correlation between region.

Language: Английский

Citations

0
Assessment of the Association Between Clinical and Laboratory Parameters and Past Coronavirus Infection in Patients with Coronary Artery Restenosis DOI Creative Commons
Gulnara Batenova, Е. И. Дедов, A. Yu. Orekhov

et al.

The Russian Archives of Internal Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 42 - 56

Published: Jan. 26, 2025

Understanding the risk factors for coronary in-stent restenosis is particularly important in patients with coronavirus disease (COVID-19). Such require careful monitoring, priority treatment, and prevention. The aim of our study was to assess association between clinical laboratory parameters previous infection artery restenosis. Materials methods. A cross-sectional conducted on a continuous sample who underwent repeated myocardial revascularization period from 2020 2023 (931 patients). 420 main group had stent restenosis, which 162 (38.5 %) suffered (CVI). control included 511 without whom 107 (20.9 undergone CVI. Laboratory tests troponin I, D-dimer, creatine kinase (CK), kinase-MB (CK-MB), serum creatinine glucose, C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate (AST) fibrinogen, IgG IgM antibodies RNA detection by polymerase chain reaction. Statistical calculations were performed using SPSS version 20.0 software. Results: It established that there statistically significantly higher levels compared group. When dividing groups into subgroups individuals CVI, significant differences found (p<0.001): level CVI CPK, CPK-MB, CRP, APTT results multiple regression analysis indicated positive relationship development infarction such indicators as blood low-density lipoproteins (LDL), well negative left ventricular ejection fraction high-density (HDL). role these predictors confirmed ROC analysis. Conclusion: an increased revascularization.

Language: Английский

Citations

0
Features of clinical blood biochemistry in patients who have suffered a new coronavirus infection DOI

Ivan S. Sadowski,

O. S. Kruglova, А. А. Савченко

et al.

Russian Journal of Immunology, Journal Year: 2025, Volume and Issue: 28(2), P. 307 - 314

Published: Feb. 16, 2025

The COVID-19 pandemic, which began in December 2019, was caused by the new coronavirus SARS-CoV-2. SARS-CoV-2 is a shell virus containing single positive chain genome and using angiotensin converting enzyme 2 (ACE2) as cell entry receptor. targeting of on several tissues expressing ACE2 explains multifactorial pattern symptoms: fever, dry cough, myalgia, fatigue shortness breath. These symptoms do not always stop after COVID-19, may reappear within 12 weeks, indicates development post-COVID syndrome (long COVID). Due to extensive comorbidity patients, clinical diagnosis difficult. aim study identify pathognomonic indices biochemical blood analysis convalescents, indicating syndrome. Patients design: retrospective observational one-moment 373 case histories outpatient records conducted for patients exposed later than weeks ago. initial course disease (disease) assessed WHO Clinical Progression Scale. severity (clinical outcomes) functional status scale (PCFS). All subjects are divided into four groups, names reflect post-ovoid condition: 1st group, “mild / 0-2 PCFS class”; 2nd 3-4 3rd “medium severe 4th class”. sample described calculating median (Me) values interquartile range expressed Q1 Q3 (Q0.25-Q0.75). reliability differences between independent samples with nonparametric Mann–Whitney U-test Student’s t-test. Upon evaluation biochemistry, alanine aminotransferase (ALT) level group 1 higher groups 4, aspartate aminotrasferase (AST) 3. indexes total cholesterol LDL did show statistically significant groups. Creatinine levels 3 1, being lower 4 other Significant were observed upon qualitative assessment C-reactive protein (CRP). There 2-3 times more elevated CRP 1. A minimal profile, including an transaminases creatinine, or quantitative protein, indicate chronic inflammation. this need undergo additional examination, e.g., general urine determination albumin urine, dynamic GFR calculation, order prevent persistent renal impairment.

Language: Английский

Citations

0
Long Term Respiratory Follow up Findings of COVID-19 Cases DOI Creative Commons
Kadir Çoban, Olcay Ayçiçek, Tevfik Özlü

et al.

Hitit Medical Journal, Journal Year: 2025, Volume and Issue: 7(1), P. 10 - 19

Published: Feb. 25, 2025

Objective: The aim of this study was to determine the long-term clinical, laboratory and radiologic findings, follow-up findings after acute infection complications in patients who recovered from COVID-19 infection, especially with insufficient data on effects. Material Method: Patients were admitted pulmonology outpatient clinic our hospital included study. Demographic data, peripheral oxygen saturation, mMRC score, 6-minute walk test ongoing symptoms, during recorded. up first 4 weeks time diagnosis grouped as visit 1, between 12 2, 3. Results: A total 520 evaluated, including 190 at interval, 203 second interval 127 third duplicate patients. 54% participants female, 46% male mean age 54 years. had least one symptom 96.3%, 90.6% 89.8% visits, respectively. most common symptoms exertional dyspnea, fatigue cough. pathologic radiographic ground glass opacities early period linear/reticular late period. rates 4.7%, 23.2%, 24.4% according intervals, respectively complication pulmonary fibrosis. Conclusion: patients; while struggling problems associated disease period, they also have struggle persistent newly developing long term. In context, we think that will form a basis for country contribute literature.

Language: Английский

Citations

0
Enduring Coagulopathy and Endothelial Dysfunction in Post-Acute COVID-19 Syndrome (PACS): A One-Year Longitudinal Cohort Study DOI
Yucan Li,

Tichao Shan,

Zhengqi Jiang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Unhealthy Food Consumption Is Associated with Post-Acute Sequelae of COVID-19 in Brazilian Elderly People DOI Creative Commons
Guilherme José Silva Ribeiro,

Rafaela Nogueira Gomes de Morais,

Olufemi Gabriel Abimbola

et al.

Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(2), P. 25 - 25

Published: March 13, 2025

Background/Objectives: The factors associated with post-acute sequelae of COVID-19 (PASC) are not yet fully understood in developing countries. Our objective was to investigate the relationship between food consumption and occurrence PASC Brazilian elderly people. Methods: This cross-sectional study included 1322 people aged 60 or over, infected SARS-CoV-2 2020, living state Roraima Brazil. Using National Food Nutrition Surveillance System (SISVAN, Portuguese) tool, markers were evaluated. persistence assessed three months after infection. Poisson regression robust variance performed estimate prevalence ratio (PR) a 95% confidence interval (95% CI). Results: Fruit [PR 0.92; CI: 0.85–0.99] lower PASC, significant interaction individuals 69 years old, hospitalized, those without chronic kidney disease. In addition, sugar-sweetened beverages 1.23; 1.12–1.35], sandwich cookies, sweets, treats 1.12; CI 1.03–1.22] positively people, capital hypercholesterolemia. Conclusions: Unhealthy An improvement diet quality is necessary minimize health complications PASC.

Language: Английский

Citations

0
Clinical indices and laboratory markers for evaluating the immune-mediated inflammation in rheumatoid arthritis: the impact of COVID-19 DOI Creative Commons
K. M. Konovalov, А. А. Баранов, N. A. Lapkina

et al.

Patient-Oriented Medicine and Pharmacy, Journal Year: 2025, Volume and Issue: 3(1), P. 49 - 58

Published: March 25, 2025

Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease of unknown etiology that represents a considerable burden for both the patient and healthcare system. The degree to which inflammation being controlled determines prognosis; therefore, achieving remission or low activity paramount importance medical practitioners. effectiveness currently employed treatment regimen specific determined by indices change in their values during treatment. commonly used RA are result painstaking search optimal set clinical, laboratory instrumental parameters reflecting underlying pathogenesis spanning half century. Routine tests not included these can nevertheless provide additional valuable information regarding disease. new coronavirus infection, COVID-19, has similar pathogenetic mechanisms with immunoinflammatory rheumatic diseases, its clinical consequences form postcovid-19 syndrome, make it difficult assess using existing indices, raise question need take them into account when assessing choosing tactics RA.

Language: Английский

Citations

0