Clinical applications of human organoids

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

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Exploiting cellulose-based hydrogels for sustainable, intelligent wearables in pandemic preparedness and control

European Polymer Journal, Journal Year: 2024, Volume and Issue: 212, P. 113041 - 113041

Published: April 15, 2024

Language: Английский

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Depressive symptomatology in Brazil: perspectives of statistical and psychometrics analyses of the PHQ-9 at four time-points (2020–2023) in the COVID-19 pandemic

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

The present research assessed the psychometric properties of Patient Health Questionnaire-9 (PHQ-9) through an examination its internal structure, invariance analysis, and standardization. Social distribution analyses measure were conducted using linear binomial logistic regression. sample consisted 10,069 adults from all 27 states in Brazil. data obtained four collections across different years COVID-19 pandemic (2020, 2021, 2022, 2023), independent samples. Confirmatory Factor Analysis (CFA) indicated that is unidimensional with satisfactory fit indices. model was invariant relation to variables investigated at levels (configural, metric, scalar, strict). standardization supported hypothetical cut scores indicating severity depressive symptoms, categorized as very low (0 6), (7 13), moderate (14 19), high (20 23), (≥ 24). We found sex/gender, skin color/ethnicity, age, education level, year predictors symptoms adjusted regression analysis. showed higher chances for a positive screening diagnosis depression, Odds Ratio follows: 2021 (OR adj = 1.275) 2023 1.409), women 1.900), Pardos individuals 1.252), up school 1.272), being northeast region resident 2.127), younger people 1.716). findings this study indicate suitability PHQ-9 assessing depression population recommend use monitoring coming Clinical implications include developing interventions address psychological impact any future health crises.

Language: Английский

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Development of Receptor-Integrated Magnetically Labeled Liposomes for Investigating SARS-CoV-2 Fusion Interactions

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

The impacts of highly pathogenic enveloped viruses, such as SARS-CoV-2, have turned scientific inquiry toward the fusion mechanisms responsible for viral pathogenesis and to seek cost-effective adaptable strategies mitigate future outbreaks. Current approaches studying SARS-CoV-2 include computational studies, pan-coronavirus inhibitors, modified peptides lipopeptides, along with various nanotechniques. Although these methodologies illuminated mechanisms, they possess key limitations that prevent their widespread utility in outbreaks, including high financial or instrumental costs, operational proficiency, cytotoxicity, specificity. This work measures changes spin-spin T2 magnetic (transverse) relaxation times using a benchtop NMR instrument introduces bioanalytical approach quickly quantify interactions between spike protein liposome-coated iron oxide nanosensors (LIONs). Additionally, this study modifies LION platform by appending angiotensin-converting enzyme (ACE2) receptor, thereby creating LIONs-ACE2 mimics ACE2 host cell receptor targeted SARS-CoV-2. Furthermore, other receptors reported be involved is also examined. Environmental factors impacting fusion, calcium ion concentration, cholesterol composition, pH, neutralizing antibodies, lower temperature, are investigated. Finally, molecular dynamics (MD) simulation studies reveal binding domain (RBD) interacts more favorably than lipid bilayer opened conformation, yet closed conformation RBD similar energy ACE2. These findings how offers customizable, fast-acting, inexpensive, accessible mechanism examining process viruses.

Language: Английский

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Porphyrins with combinations of 4-carboxyphenyl and 4-hydroxyphenyl substituents in meso-positions as anti-HIV-1 agents

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 1, 2024

Abstract A series of 4-carboxyphenyl/4-hydroxyphenyl meso -substituted porphyrins were synthesized, purified, and characterized. The compounds exhibited anti-HIV-1 activities, in vitro, under both non-photodynamic (non-PDT) photodynamic (PDT) conditions. Specifically, the inhibited HIV-1 virus entry, with c-PB 2 (OH) PB(OH) 3 showing significant activity. All subtype B C entry PDT Our study demonstrated that bearing combinations moieties not toxic even at higher concentrations, as compared to reference 5,10,15,20-tetra-(4-carboxyphenyl)porphyrin ( TCPP ) 5,10,15,20-tetra-(4-hydroxyphenyl)porphyrin THPP ), This underscores promising potential these HIV inhibitors non-PDT scenarios.

Language: Английский

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Combinations of meso-(4-carboxyphenyl) and meso-(4- hydroxyphenyl) porphyrins as anti-HIV-1 agents

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 6, 2024

A series of 4-carboxyphenyl/4-hydroxyphenyl meso-substituted porphyrins were synthesized, purified, and characterized. The compounds exhibited anti-HIV-1 activities, in vitro, under both non-photodynamic (PDT) photodynamic conditions. Specifically, the inhibited HIV-1 virus entry, with c-PB₂(OH)₂ PB(OH)₃ showing significant activity. All subtype B C entry PDT Our study demonstrated that bearing combinations moieties not toxic even at higher concentrations, as compared to reference 5,10,15,20-tetra-(4-carboxyphenyl)porphyrin (TCPP) 5,10,15,20-tetra-(4-hydroxyphenyl)porphyrin (THPP), This highlighted promising potential target HIV inhibitors in non-PDT settings.

Language: Английский

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Dissemination of Misinformation About COVID-19 on TikTok: A Multimodal Analysis

Communications in computer and information science, Journal Year: 2024, Volume and Issue: unknown, P. 109 - 120

Published: Jan. 1, 2024

Language: Английский

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