Spike protein-related proteinopathies: a focus on the neurological side of spikeopathies
Annals of Anatomy - Anatomischer Anzeiger,
Journal Year:
2025,
Volume and Issue:
unknown, P. 152662 - 152662
Published: April 1, 2025
Language: Английский
The Neurological Implications of COVID-19: A Comprehensive Narrative Review
Ithamar Cheyne,
No information about this author
Venmanassery Sreejan Gopinath,
No information about this author
Neeharika Muppa
No information about this author
et al.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 15, 2024
The
COVID-19
pandemic
caused
by
the
coronavirus
SARS-CoV-2
revealed
a
huge
number
of
problems
as
well
discoveries
in
medicine,
notably,
regarding
effects
virus
on
central
nervous
system
(CNS)
and
peripheral
(PNS).
This
paper
is
narrative
review
that
takes
deep
dive
into
complex
interactions
between
NS.
Therefore,
this
explains
broad
range
neurological
manifestations
neurodegenerative
diseases
virus.
It
carefully
considers
routes
through
which
reaches
NS,
including
olfactory
course,
hematogenous
route,
are
also
covered
when
discussing
virus's
direct
indirect
mechanisms
neuropathogenesis.
Besides
pathologies
such
stroke,
encephalitis,
Guillain-Barré
syndrome,
Parkinson's
disease,
multiple
sclerosis,
focus
area
given
to
challenges
making
diagnosis,
treatment,
management
these
conditions
during
pandemic.
examines
strategic
interventional
approaches
utilized
prevent
disorders,
ACE2
receptors
implicated
mediation
COVID-19.
detailed
overview,
combines
research
outputs
with
case
data,
directed
at
tackling
challenge,
view
toward
better
patient
care
outcomes
future.
Language: Английский
COVID-19 Modified mRNA “Vaccines”: Lessons Learned from Clinical Trials, Mass Vaccination, and the Bio-Pharmaceutical Complex, Part 2
International Journal of Vaccine Theory Practice and Research,
Journal Year:
2024,
Volume and Issue:
3(2), P. 1275 - 1344
Published: Aug. 16, 2024
The
COVID-19
modified
mRNA
(modmRNA)
lipid
nanoparticle-based
“vaccines”
are
not
classical
antigen-based
vaccines
but
instead
prodrugs
informed
by
gene
therapy
technology.
Of
considerable
note,
these
products
have
been
linked
to
atypical
adverse
and
serious
event
profiles.
As
discussed
in
Part
1,
health-related
risks
drawbacks
were
drastically
misreported
underreported
the
Pfizer
Moderna
trial
evaluations
of
genetic
products.
Now
2,
we
examine
main
structural
functional
aspects
injectables.
modmRNA
injectable
introduce
a
unique
set
biological
challenges
human
body
with
potential
induce
an
extensive
range
adverse,
crippling,
life-threatening
effects.
Based
on
fact
that
there
is
no
current
method
quantify
host
(cell-based)
spike
protein
production
vivo
following
injection
prodrugs,
standard
“dose”.
This
part
due
differences
output,
which
depends
cell
metabolism
transfection
efficiency.
It
therefore
difficult
predict
profiles
individual
basis,
considering
millions
adults
across
world
reported
severe
events
context
products,
valid
concerns
raised
regarding
infants
younger
age
groups
for
whom
poses
only
minimal
risks.
We
address
process-related
impurities
inherent
mass
posed
contaminants.
then
categorize
principal
associated
brief
systems-based
synopsis
each
six
domains
harms:
(1)
cardiovascular,
(2)
neurological,
(3)
hematologic;
(4)
immunological,
(5)
oncological,
(6)
reproductive.
conclude
discussion
primary
public
health
regulatory
issues
arising
from
this
evidence-informed
synthesis
literature
reiterate
urgency
imposing
global
moratorium
modmRNA-LNP-based
platform.
Language: Английский
The “Tipping Point” : When Electroencephalography (EEG), Quantitative EEG (QEEG) and Standardized Low Resolution Brain Electromagnetic Tomography (sLORETA) in COVID Went From “Ceasure” To “Non- Priority” To “First-Line” Tool in Triage, Diagnosis, Monitoring and Therapy
Neurology and Neuroscience,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: March 30, 2024
On
the
threshold
of
COVID
outbreak;
electroencephalography
(EEG)
was
used
in
diagnosis,
crossborder
disease
differential
disease-staging,
monitoring
treatment,
sedation
and
coma,
neuro-therapy
declaration
brain
death.
EEG,
quantitative
EEG
(QEEG),
standardized
low
resolution
electromagnetic
tomography
(sLORETA)
use
entered
doldrums;
reaching
near
“ceasure”
due
to
restrictions.
Between
2020-2023,
tipped,
going
from
“Ceasure”
“First-Line”
tool
triage,
therapy
neurological,
neurocognitive,
neuropsychiatric,
neuromuscular
sequelae
para-
or
acute-
post-COVID-19.
The
present
paper
will
discuss
this
“Tipping
point”
QEEG
sLORETA
use.
Language: Английский
Neurological Complications of COVID-19 Vaccination: A Case Report of Generalized Convulsive Status Epilepticus
International Journal of Medical and Pharmaceutical Case Reports,
Journal Year:
2023,
Volume and Issue:
16(4), P. 80 - 86
Published: Dec. 7, 2023
Generalized
convulsive
status
epilepticus
(GCSE)
is
a
life-threatening
condition
characterized
by
prolonged
seizure
activity
that
affects
both
sides
of
the
brain.
Despite
its
high
mortality
rate,
GCSE
relatively
rare
complication
COVID-19
vaccination.
In
this
case
report,
we
presented
28-year-old
male
with
no
known
history
neuropsychiatric
disorders
who
developed
following
first
dose
mRNA
vaccine.
It
plausible
vaccine
played
role
in
development
patient.
This
report
also
provides
brief
review
potential
association
between
vaccination
and
GCSE.
Enhanced
post-vaccination
monitoring
protocols
are
essential
for
ensuring
safety
patients
underlying
medical
conditions
or
those
at
heightened
risk
neurological
complications.
Language: Английский