Self‐ or Acridinium‐Catalyzed Electrophotosynthesis of Thiocyanato Heterocycles from Activated Alkenes

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(10), P. 2352 - 2362

Published: April 5, 2024

Abstract While the emergence of electrophotochemistry provides opportunities, such a chemistry at this stage suffers from limited reaction types and high photocatalyst loadings. A self‐catalyzed electrophotosynthesis as well one with low loading is presented. These external‐oxidant‐free cyclizations are enabling applicable to range activated alkenes, affording diverse array thiocyanato heterocycles including 4‐pyrrolin‐2‐ones, isoquinoline‐1,3‐diones, indolo[2,1‐ ]isoquinolin‐6(5 H )‐ones, benzoimidazo[2,1‐ )‐ones indolin‐2‐ones, protocols amenable late‐stage diversification complex molecular architectures gram‐scale syntheses. Sunlight could serve light source, be conducted in an all‐solar‐driven mode using commercially available photovoltaic panel produce electricity.

Language: Английский

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Electrophotocatalysis Versus Indirect Electrolysis: Electrochemical Selenocyclization of 3‐Aza‐1,5‐dienes Facilitated by Energy Transfer, Direct Photolysis or N‐Hydroxyphthalimide

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(36)

Published: April 23, 2024

Three hybrid electrochemical protocols, which involve the energy transfer, direct photolysis and N-hydroxyphthalimide catalyst, respectively, are presented for selenylation/cyclization of fragile substrates 3-aza-1,5-dienes with diorganyl diselenides to afford 3-selenomethyl-4-pyrrolin-2-ones. The two electrophotocatalytic reactions indirect electrolysis one both regioselective external-oxidant- transition-metal-free, associated a broad substrate scope high Se-economy, all three methods amenable gram-scale syntheses, late-stage functionalizations, sunlight-induced experiments all-solar-driven syntheses.

Language: Английский

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Eleven new metabolites of fluvoxamine detected in the solid tissues and body fluids obtained from a deceased overdosed with fluvoxamine in vivo, and the metabolites in the human liver microsomes in vitro using LC-HR–MS/MS

Forensic Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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COVID-19-associated mortality in individuals with serious mental disorders in Sweden during the first two years of the pandemic– a population-based register study

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 7, 2024

Abstract Background Reports at the beginning of COVID-19 pandemic suggested differences in COVID-19-associated mortality between individuals with serious mental disorders (SMD) and population large. Aim To compare pattern without SMD Sweden over two main years. Methods We compared during 2020 2021. For SMD, we included psychotic disorder, bipolar severe depression. The analysis was based on summary data from Swedish Board Health Welfare covering entire adult population. Results overall relative risk (RR) for experiencing a death 1.66 (CI 1.50–1.83; p < 0.001) versus SMD. corresponding RRs were 3.25 2.84–3.71; 1.06 0.88–1.26; = 0.54) 1.03 0.80–1.32; 0.80) Compared to their respective counterparts non-SMD group, disorder depression RR higher women than men. In men women. generally younger Individuals psychosis 18 59 years had highest 7.25 4.54–11.59; p<0.001). Conclusions particularly those disorders, general As this is also seen other infections, people may be similarly vulnerable future pandemics.

Language: Английский

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Drug–Drug Interactions of Selective Serotonin Reuptake Inhibitors: A Pharmacovigilance Study on Real-World Evidence from the EudraVigilance Database

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1278 - 1278

Published: Sept. 26, 2024

As the most common psychiatric symptom, depression represents a subject of high interest for medical community.

Language: Английский

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DABCO‐Mediated Photoelectrochemical Three‐Component Sulfonocyclization of 3‐Aza‐1,5‐dienes

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Comprehensive Summary Herein, we report a rare example of three‐component net‐oxidative sulfonylation SO 2 surrogate with an oxidatively activated radical precursor under mild and metal‐ external‐oxidant‐free conditions. The mildness sustainability the reaction are enabled by photoelectrocatalysis, 3‐aza‐1,5‐dienes, organotrifluoroborates 1,4‐diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO) undergo sulfonylative cyclization to afford sulfono 4‐pyrrolin‐2‐ones in atom‐economical manner broad substrate scope good functional‐group tolerance. protocol is amenable late‐stage diversification complex molecular architectures as well gram‐scale synthesis. Sunlight could be used light source, conducted all‐solar mode using commercially available photovoltaic panel generate electricity situ . Mechanistic studies reveal that generated (DABCO), which was generally innocent previous reactions, functions electron shuttle between photocatalytic cycle reactants.

Language: Английский

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Systems medicine framework for repurposable drug combinations for COVID-19 comorbidities

Medicine in Omics, Journal Year: 2024, Volume and Issue: 11, P. 100038 - 100038

Published: May 22, 2024

Currently, vaccines have shown efficacy against new SARS-CoV-2 variants. This study aimed to develop a systems medicine framework that can predict and validate drug combinations be repurposed for treating COVID-19 its comorbidities, specifically type 2 diabetes hypertension. found gut microbes could potentially influence the action of drugs, innate immune response, intestinal dysfunction, susceptibility virus in individuals with these comorbidities. It was also discovered spike protein interacts 57 human genes, many which are linked food-borne bacteria. An analysis disease enrichment showed arthritis hypertension were frequently observed as comorbidities patients infected SARS-CoV-2. Several including Fluvoxamine, Donepezil, Ifenprodil, been identified repurposable drugs Moreover, nitazoxanide tocilizumab (antivirals), bacitracin (antibacterial), gliclazide (antidiabetics) potential drugs. Tocilizumab effective diabetes. A combination lidocaine has suggested

Language: Английский

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Fluvoxamine and long COVID: Post‐acute recovery

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(4)

Published: June 2, 2024

Deidentified participant data may be shared for pre-planned analyses and meta-analyses after review of proposal, if approved by the principal investigators. For access enquiries, email [email protected].

Language: Английский

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Die Bedeutung von Antidepressiva bei COVID-19 und Long-COVID – Ein Scoping-Review Update

Fortschritte der Neurologie · Psychiatrie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Introduction Preclinically, fluvoxamine and other antidepressants (AD) exerted antiviral anti-inflammatory properties also against SARS-COV-2. Therfore, It makes sense to test the clinical effect of AD COVID-19 Long COVID.

Language: Английский

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