Prioritization of Vaccines for Introduction in the National Immunization Program in the Republic of Korea DOI Creative Commons
Won Suk Choi,

Yeonhee Sung,

Jimin Kim

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(8), P. 886 - 886

Published: Aug. 4, 2024

This study presents a framework for determining the prioritization of vaccine introduction in National Immunization Program (NIP) Republic Korea, with focus on case examples assessed 2021 and 2023. We describe predefined criteria evaluating vaccines NIP established process Korea. These included disease characteristics, rationality efficiency resource allocation, acceptance immunization. The prioritizing involved several sequential steps: demand survey, evidence collection, preliminary evaluation, priority decision making. In 2023, 14 25 committee members participated NIP, respectively. Overall, 13 19 candidates were 2023 evaluations, Through Delphi survey consensus processes, order was determined: vaccination against Rotavirus infection top 2021, while Influenza 4v (for chronic patients) took precedence demonstrates an evidence-based decision-making within healthcare field. outlined approach may provide valuable guidance policymakers other countries seeking to prioritize inclusion new their NIP.

Language: Английский

Vaccines and monoclonal antibodies: new tools for malaria control DOI
Kazutoyo Miura, Yevel Flores-García, Carole A. Long

et al.

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(2)

Published: April 24, 2024

SUMMARYMalaria remains one of the biggest health problems in world. While significant reductions malaria morbidity and mortality had been achieved from 2000 to 2015, favorable trend has stalled, rather increases cases are seen multiple areas. In 2022, there were 249 million estimated cases, 608,000 malaria-related deaths, mostly infants children aged under 5 years, globally. Therefore, addition expansion existing anti-malarial control measures, it is critical develop new tools, such as vaccines monoclonal antibodies (mAbs), fight malaria. last 2 first second vaccines, both targeting

Language: Английский

Citations

11
Globally approved vaccines for COVID-19: a systematic review DOI

Bárbara Magalhães,

Jéssica Medeiros Minasi, Rubens Cáurio Lobato

et al.

Brazilian Journal of Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

Citations

1
Retrospective Clinical Investigation into the Association Between Abnormal Blood Clotting, Oral Anticoagulant Therapy, and Medium-Term Mortality in a Cohort of COVID-19 Patients DOI Creative Commons
Giorgia Dinoi, Maria Vittoria Togo, Pietro Guida

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 535 - 535

Published: Feb. 20, 2025

Background/Objectives: People affected by COVID-19 are exposed to abnormal clotting and endothelial dysfunction, which may trigger thromboembolic events. This study aimed at retrospectively investigating whether oral anticoagulant therapy (OAT), encompassing either direct anticoagulants (DOACs), mainly apixaban, or the vitamin K antagonist (VKA) warfarin, could have impacted medium-term mortality in a cohort of SARS-CoV-2 patients. Methods: Among 1238 patients, hospitalized from 17 March 2020 15 June 2021, 247 survivors deceased within 90 days hospitalization were matched 1:1 based on age, sex, intensive care unit (ICU) admission three days. Conditional logistic regression was used estimate associations means odds ratio (OR) with 95% confidence interval (CI). Results: A univariate analysis suggested that OAT, no differently subcutaneous low-molecular-weight heparins (LMWHs) during hospitalization, has significant impact (p value > 0.05) mortality. multivariate analysis, limited baseline variables (i.e., comorbidities pharmacotherapies hospital admission) showing association < revealed that, compared patients living had cancer histories (OR 1.75, CI 1.06–2.90, p = 0.029) suffered asthma 2.25, 1.13–4.47, 0.021). In contrast, heart failure (HF), atrial fibrillation (AF), arteriopathy, chronic obstructive pulmonary disease (COPD), kidney (KF), which, found be associated endpoint 0.05), lost significance analysis. Therapy aldosterone antagonists also appeared 2.49, 1.52–4.08, 0.001); whereas, D supplementation beneficial. Although not conclusive, search into Eudravigilance database, combined consulting digital predictive platform (PLATO, polypharmacology prediction), potential off-target activities, might contribute increasing severity infection. Conclusions: retrospective clinical furnished evidences other pharmacological treatments course.

Language: Английский

Citations

1
The relationship between vaccination and uveitis: A comprehensive review of immune response, risk assessment, and clinical implications DOI Creative Commons
Yihan Zhang, Tianyu Tao, Zhaohuai Li

et al.

Eye & ENT Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract Uveitis, an intraocular inflammatory condition, can lead to significant visual impairment and is often associated with abnormal immune system activation. While vaccination stands as a pivotal defense against numerous infectious diseases, its safety effectiveness in individuals uveitis have come under heightened scrutiny. This concern arises from the potential impact of both disease itself immunosuppressive treatments on function. Several studies drawn connections between various vaccines onset uveitis, particularly hepatitis B, human papillomavirus, influenza vaccines. Furthermore, though exceedingly rare, instances following COVID‐19 been documented, adding another layer complexity. review delves into intricate relationship assesses risks for those afflicted, explores underlying mechanisms behind vaccine‐induced uveitis. Finally, it offers recommendations patients emphasizes imperative further investigation unravel complex dynamics ultimately informing clinical practice.

Language: Английский

Citations

1
Bioaerosols and Airborne Transmission in the Dental Clinic DOI Creative Commons
James R. Allison,

Stefanie Tiede,

Richard Holliday

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: 74, P. S418 - S428

Published: Nov. 1, 2024

The importance of aerosols (particles suspended in air) produced during dental procedures became more apparent than ever the COVID-19 pandemic. Concerns over transmission infection these led to unprecedented disruption services across world, adversely impacting patients' oral health. This article discusses evidence related airborne infectious diseases and relevance dentistry. production bioaerosols (aerosols carrying biological material) is explored, as well how potential risks posed by can be controlled. A better understanding needed prevent similar future outbreaks, reduce risk professionals when treating patients with active infections who require urgent or emergency care.

Language: Английский

Citations

4
Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production DOI Creative Commons
Beatriz Castro‐Robles, Francisco J. Cimas,

Lourdes Arias-Salazar

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Despite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since impact COVID-19 vaccines on endothelium remains uncertain, our objective was to assess endothelial activation status before 90 days after third dose BNT162b2 mRNA vaccine. A prospective longitudinal study conducted at University General Hospital Albacete, involving 38 healthy health-care workers. Serum levels markers (endocan sVCAM-1) spike S1-specific IgG antibodies were determined 7, 15, 24 90days following vaccination. To analyze each participant´s individual response, we calculated relative increases/decreases (delta values) in concentrations compared their pre-vaccination levels. We identified two significantly distinct profiles characterized by either increased or decreased serum endocan sVCAM. Incremental decremental response groups did not differ terms age, sex, cardiovascular risk factors, previous infection influenza vaccine co-administration. However, these responses associated with spike-specific antibody production. Specifically, greatest increase found responders. Additionally, higher delta production observed non-previously infected individuals. Administration booster triggered a non-homogenous function among participants. Our findings improve understanding vaccine, which could be useful assessing need for doses, particularly population vascular complications.

Language: Английский

Citations

0
Broad-spectrum affinity chromatography of SARS-CoV-2 and Omicron vaccines from ligand screening to purification DOI
Jing Ma, Xiaoyan Dong, Yan Sun

et al.

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1743, P. 465685 - 465685

Published: Jan. 17, 2025

Language: Английский

Citations

0
Assessing the effectiveness of vaccination strategies against respiratory pathogens⁠ DOI Open Access

Mohammad Puad Abdullah,

Faisal M. Alanazi,

Saad F. Gandurah

et al.

International Journal of Community Medicine and Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Vaccination has been an effective method in preventing many childhood-related infections and reducing the risk of adults. Between mid-1960s 2015, vaccination successful saving more than 10 million lives. Respiratory pathogens have a main target for over decades. Many vaccines were developed against respiratory such as influenza. virus, Streptococcus pneumoniae, Mycobacterium tuberculosis. faces new challenges every year due to different reasons. The following databases used systematic research: Medline (PubMed), Web Science, Scopus. Summaries found studies exported by EndNote X8, duplicate removed. Inclusion criteria any study. Despite proven effectiveness various pathogens, several persist this field. These include waning vaccine-induced immunity, prompting need developing that provide long-lasting protection; harmful side effects; emergence subtypes are examples these challenges. In aftermath COVID-19 pandemic, clinical trials underway develop range pathogens. However, greater large-scale efforts needed, particularly low-income countries, enhance global public health outcomes.

Language: Английский

Citations

0
Longitudinal Assessment of Pulmonary Involvement and Prognosis in Different Subtypes of COVID-19 Patients After One Year Using Low-Dose CT: A Prospective Observational Study DOI

Jinyang Zhao,

Liang Dong,

Xue Jiao

et al.

Academic Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe outcomes in adults: a systematic review and meta-analysis of European studies published up to 22 January 2024 DOI Creative Commons
Guiling Zhou,

Nina Dael,

Stefan Verweij

et al.

European Respiratory Review, Journal Year: 2025, Volume and Issue: 34(175), P. 240222 - 240222

Published: Jan. 1, 2025

Background Up-to-date evidence from European studies on long-term vaccine effectiveness (VE) of COVID-19 vaccines is lacking. This review aimed to evaluate and durability primary series boosters in preventing infection severe outcomes the population. Methods We conducted systematic searches PubMed Embase up 22 January 2024. included observational that evaluated VE against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or disease (hospitalisation, intensive care unit admission death) for Europe. applied a random-effects meta-analysis model. Results 33 over 56 million participants. The overall complete with any SARS-CoV-2 variant was 70.7%. lower Omicron, at 26.1%, than pre-Omicron strains, 77.0%. Over time, by decreased 68.9% 38.9% after 6 months. Boosters restored 76.4% maintained 58.4% 3 due 87.4%, 93.3% 62.8% Omicron strains. Protection declined less infection. months series, still provided 50% protection caused Omicron. 87.9% 78.5% Conclusion declines markedly time variants. more durable resistant viral mutation. protection, emphasising need timely booster vaccination vulnerable populations.

Language: Английский

Citations

0