A One Health Zoonotic Vector Borne Infectious Disease Family Outbreak Investigation

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 110 - 110

Published: Jan. 23, 2025

This study reinforces the value of a One Health approach to infectious disease outbreak investigations. After onset neuropsychiatric symptoms in their son, our investigation focused on family composed mother, father, two daughters, dogs, and rabbit, all with exposures vectors (fleas ticks), rescued other animals. Between 2020 2022, members experienced illnesses that included neurological symptoms. Prolonged menorrhagia (130d) youngest daughter ultimately resolved following antibiotic administration. dog was diagnosed splenic hematoma months later spinal histiocytic sarcoma. The both one were seroreactive multiple Bartonella spp. antigens, whereas mother son not seroreactive. quintana DNA amplified from specimens obtained members. Based upon sequencing, infection B. confirmed for pet dogs. henselae sequenced daughter, (co-infected quintana), Ctenocephalides felis collected rabbit. All five infected Babesia divergens-like MO-1. Both parents co-infected microti. Droplet digital PCR supported potential Borrelia species three provided additional case-based evidence supporting role stealth Babesia, Bartonella, pathogens as cause or cofactor We conclude approach, particularly vector borne such spp., will enhance clinical epidemiological understanding these organisms animal human health. During investigations it is critical document travel exposure histories, symptoms, pathology pets patients, contact rescued, wild, feral animals perform diagnostic testing includes members, pets, vectors.

Language: Английский

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Surveillance of SARS‐CoV‐2 in Pets of Harris County, Texas, Revealed More Common Pet Infections in Households With Human COVID‐19 Cases

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(2)

Published: Jan. 27, 2025

ABSTRACT Local health departments can play a critical role in zoonoses surveillance at the human–domestic animal interface, especially when existing public services and close relationships with community groups be leveraged. Investigators Harris County Veterinary Public Health employed community‐based tool for identifying severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infections dogs cats June‐–December 2021. Diagnosis was made using both RT‐qPCR testing of oral nasal swabs plaque reduction neutralization serum samples. Recruitment this free companion program occurred through following two streams: case‐based event‐based. The stream recruited animals confirmed human COVID‐19 cases case investigations platform used information from epidemiological owners to conduct further their pet(s). event‐based participating or low‐cost spay/neuter events Pets Resource Center (HCPRC). A total 97 were tested, streams accounting 36 61, respectively. 13 (13.4%) tested seropositive including one that also had positive swabs. Of positives, 11 (84.6%) associated SARS‐CoV‐2 living same household four out seven neutralizing antibodies. These methods local level emphasize importance One approach provide model future systems.

Language: Английский

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Viruses of free-roaming and hunting dogs in Uganda show elevated prevalence, richness and abundance across a gradient of contact with wildlife

Journal of General Virology, Journal Year: 2024, Volume and Issue: 105(7)

Published: July 24, 2024

Domestic dogs (

Language: Английский

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A Comprehensive Study of Cellular and Humoral Immunity in Dogs Naturally Exposed to SARS-CoV-2

Transboundary and Emerging Diseases, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was identified as the causal agent behind disease 2019 (COVID‐19), a declared pandemic in 2020. Because of zoonotic origin SARS‐CoV‐2 and close contact kept by domestic dogs with their owners, it became imperative to understand role epidemiology virus transmission. In present study, we determined presence described long‐term immune effects 24 exposed environment. Our findings highlight that only subset dogs, naturally SARS‐CoV‐2, exhibit humoral response new (close 17% had IgM antibodies 33% has IgG antibodies). We for first time SARS‐CoV‐2‐specific IFN‐ γ ‐secreting cells (approximately half our dogs). While 56% maintained 8 months, 22% cellular after 4 months. Although some alterations blood parameters proinflammatory cytokines were described, there no evidence indicating an exacerbated cytokine release process. Considering none animals enrolled this study showed viral shedding presented specific responses, is reasonable propose canine system certain companion effective at blocking negative replication, thereby suggesting would not be potential transmitters pathogen other or species could aid promoting collective immunity.

Language: Английский

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Small animal review

Companion animal, Journal Year: 2024, Volume and Issue: 29(6), P. 86 - 86

Published: May 29, 2024

The world continues to recover from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, and although impact of disease has been reduced as a result vaccination, increased immunity less variants, it is still worldwide significance. Four recent studies look at role domestic animals in epidemiology disease.

Language: Английский

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