Nanoparticle‐Based Therapies for Neurotropic Viral Infections: Mechanisms, Challenges, and Future Prospects

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Aug. 19, 2024

Neurotropic viral infections pose a significant challenge due to their ability target the central nervous system and cause severe neurological complications. Traditional antiviral therapies face limitations in effectively treating these infections, primarily blood-brain barrier, which restricts delivery of therapeutic agents system. Nanoparticle-based have emerged as promising approach overcome challenges. Nanoparticles offer unique properties that facilitate drug across biological barriers, such can be engineered possess activities.

Language: Английский

Immune Evasion Mechanism of Neurotropic Viruses

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(6)

Published: Oct. 9, 2024

ABSTRACT The persistent challenge posed by viruses that infect the central nervous system lies in their sophisticated ability to evade host immune system. This review explores into complex mechanisms of evasion employed these neurotropic viruses, focussing on modulation responses, adaptive immunity, and cellular molecular strategies enable persistence. Key areas explored include viral latency reactivation, inhibition apoptosis, antigenic variation, with a detailed examination proteins interactions processes.

Language: Английский