Increased physical performance and reduced fatigue after personalised physiotherapy and nutritional counselling in long COVID DOI Creative Commons
B García,

Stijn Roggeman,

Lynn Leemans

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract Background Long COVID is a multisystemic condition with debilitating symptoms, including fatigue and post-exertional malaise. Personalised nutritional counselling physiotherapy could provide synergistic effect to alleviate these symptoms. However, there lack of evidence the feasibility effectiveness such personalised multimodal therapy (PMT) both nutrition physiotherapy. Methods In this pilot study, 65 participants were randomised into either standard or PMT. Nutritional focussed on tailoring energy protein intake individual needs based indirect calorimetry assessments. focused symptom-contingent pacing. The aim was evaluate in light controlled trial (RCT) assess PMT compared Effectiveness outcomes (1-minute sit-to-stand test (1-MSTS), 6-minute walk (6-MWT), Multidimensional Fatigue Inventory (MFI-20)) assessed after 6, 12 18 weeks. Descriptive statistics sample size calculations performed. Results We observed an advancement groups, however, group showed significant improvement, for 1-MST, 6-MWT physical at Participant specific trajectories suggest growing estimated difference between groups throughout trial. To prove interesting finding, 181 should be recruited RCT. Study proven. Conclusions study revealed positive trend improved function reduced adults long combined A large-scale RCT needed effectiveness, but current results are hopeful.

Language: Английский

Eleven new metabolites of fluvoxamine detected in the solid tissues and body fluids obtained from a deceased overdosed with fluvoxamine in vivo, and the metabolites in the human liver microsomes in vitro using LC-HR–MS/MS DOI
Kayoko Minakata, Hideki Nozawa,

Itaru Yamagishi

et al.

Forensic Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Post-COVID-19 Pandemic Sequelae in Liver Diseases DOI Creative Commons
Cristina Stasi

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 403 - 403

Published: March 4, 2025

During the coronavirus disease 2019 (COVID-19) pandemic, several studies highlighted a worse prognosis for patients with alterations in liver function tests, especially those pre-existing diseases. However, further are needed to define long-term impact of COVID-19 pandemic on Long encompasses wide range signs and symptoms, including exacerbations chronic conditions or new onset developed after acute phase. Therefore, effects extensively include hepatic manifestations. The co-expression angiotensin-converting receptor 2 (ACE2) transmembrane serine protease (TMPRSS2) has been demonstrated also enterocytes, cholangiocytes, hepatocytes. Studies post-COVID-19 sequelae have shown presence steatosis necroinflammation liver, concomitantly an alteration inflammation, cytolysis cholestasis indices. Some increased risk hepatobiliary pathologies, secondary biliary cholangitis worsening severity metabolic-associated fatty (MASLD). Based these premises, this review aims provide overview pathophysiological mechanisms contributing COVID-19-related damage; explore its implications inflammation fibrosis, particular focus MASLD metabolic dysfunction-associated steatohepatitis (MASH); analyze short- sequelae. A literature search was conducted using PubMed database relevant published English.

Language: Английский

Citations

0
COVID-19 and Diabetes: Persistent Cardiovascular and Renal Risks in the Post-Pandemic Landscape DOI Creative Commons
Tzu-Shan Huang,

Jo-Yen Chao,

Ho-Hsiang Chang

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 726 - 726

Published: April 30, 2025

The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), disproportionately affects individuals with diabetes mellitus (DM) exacerbating cardiovascular and renal complications. This increased risk is mediated through immune dysfunction, chronic inflammation, hyperglycemia, dysregulation of renin-angiotensin system dysregulation, endothelial hypercoagulability. Epidemiological studies indicate a two-fold stroke end-stage disease in SARS-CoV-2-infected diabetes, along 60% higher disease. While antidiabetic therapies like sodium-glucose cotransporter-2 inhibitors glucagon-like peptide-1 receptor agonists show potential protective effects, insulin use hospitalized patients linked to mortality. Vaccination crucial reducing severe COVID-19 outcomes mitigating post-infection complications, including new-onset diabetes. concerns exist regarding vaccine-associated nephropathy thromboembolic events, these risks are thought be minimal compared the benefits. As shifts an endemic phase, long-term DM remain uncertain, highlighting urgent need for continued research targeted management strategies.

Language: Английский

Citations

0
Increased physical performance and reduced fatigue after personalised physiotherapy and nutritional counselling in long COVID DOI Creative Commons
B García,

Stijn Roggeman,

Lynn Leemans

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract Background Long COVID is a multisystemic condition with debilitating symptoms, including fatigue and post-exertional malaise. Personalised nutritional counselling physiotherapy could provide synergistic effect to alleviate these symptoms. However, there lack of evidence the feasibility effectiveness such personalised multimodal therapy (PMT) both nutrition physiotherapy. Methods In this pilot study, 65 participants were randomised into either standard or PMT. Nutritional focussed on tailoring energy protein intake individual needs based indirect calorimetry assessments. focused symptom-contingent pacing. The aim was evaluate in light controlled trial (RCT) assess PMT compared Effectiveness outcomes (1-minute sit-to-stand test (1-MSTS), 6-minute walk (6-MWT), Multidimensional Fatigue Inventory (MFI-20)) assessed after 6, 12 18 weeks. Descriptive statistics sample size calculations performed. Results We observed an advancement groups, however, group showed significant improvement, for 1-MST, 6-MWT physical at Participant specific trajectories suggest growing estimated difference between groups throughout trial. To prove interesting finding, 181 should be recruited RCT. Study proven. Conclusions study revealed positive trend improved function reduced adults long combined A large-scale RCT needed effectiveness, but current results are hopeful.

Language: Английский

Citations

0