A large-scale retrospective study on the prevalence of human papillomavirus and its genotypes in humans referred to a medical laboratory in Isfahan, central Iran DOI Creative Commons

Bahram Bagherpour,

Rasool Jafari,

Akbar Hassanpour

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Introduction: Human papillomavirus (HPV) causes the most prevalent sexually transmitted infection. It is important cause of cervical cancer. The present study aimed to determine prevalence HPV infection and genotypes in recordings patients referred Dr. Sharifi Medical Laboratory Isfahan, central Iran. Materials Methods In a retrospective study, PCR genotyping results 5643 including 4999 (88.6%) females 644 (11.4%) males from May 2012 August 2024 were studied. available demographics, sex age, also recorded analyzed. Results Of studied patient, 888 (15.7%) HPV-positive. Genotype 6 was (9.1%), 30 71 least (0.017%) identified genotypes. Out 888, 470 (47.1%) 418 (52.9%) high-risk low-risk genotypes, respectively. 16 among followed by 53 18. significantly higher under 20 years old compared males. Conclusion Based on rate Isfahan close that other regions with low- both women. High-risk caused majority infections. Younger ages at-risk group for

Language: Английский

Epidemiological Characteristics and Prevention Strategies of High-Risk HPV Genotypes in Cervical Cancer DOI

红丽 丁

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 428 - 435

Published: Jan. 1, 2025

Language: Английский

Citations

0
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells DOI Creative Commons
Jingwei Liu, Tong Shu, Yulian Mu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Background Human papillomavirus (HPV) infection is a worldwide reproductive system disease. Baofukang suppository, traditional herbal preparation that includes curdione and borneol, has been reported to treat bacterial vaginosis (BV) HPV in China. However, the therapeutic mechanism still unknown. This study aims explore molecular mechanisms of borneol treating infection. Methods We conducted retrospective cohort analysis medical records from single-center involving 205 patients, focusing on correlation between clearance co-infection with other pathogens, confirming efficacy suppository. Bioinformatics network pharmacology approaches were employed identify targets suppository for BV/HPV co-infections. qRT-PCR, Western blot, immunofluorescence staining, flow cytometry utilized validate along associated immune changes. Finally, confirmed vivo using an LPS/TC-1 cervical orthotopic injection model. Results Curdione selectively inhibit secretion interleukin-6 (IL-6) interleukin-1β (IL-1β) by macrophages. The reduction IL-6 IL-1β levels effectively inhibits expression CD274 (Programmed death ligand 1, PD-L1) infected epithelial cells inhibiting STAT3 phosphorylation, thereby suppressing their evasion capabilities. Furthermore, enhance tumor necrosis factor α (TNF-α) caspase 1 (CASP1) macrophages, as well interleukin 12 (IL-12) 23 (IL-23) dendritic (DCs). these inflammatory factors promotes migration differentiation T site infection, completing cells. Conclusion main components progression occurrence cancer modulating communication innate adaptive immunity, promoting recruitment recognition CD8 + eliminate HPV-infected

Language: Английский

Citations

0
Human papillomavirus oropharyngeal cancer and vaccine: present and future perspective DOI
Stefano Zorzi, Marta Tagliabue, Rita De Berardinis

et al.

European Journal of Cancer Prevention, Journal Year: 2025, Volume and Issue: 34(2), P. 113 - 114

Published: Jan. 29, 2025

Zorzi, Stefano; Tagliabue, Marta; De Berardinis, Rita; Chu, Francesco; Ansarin, Mohssen Author Information

Language: Английский

Citations

0
L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005–2016 DOI Creative Commons
Xiaotong Chen, Honglei Chen, Yuling Chen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 11, 2025

Background Human Papillomavirus (HPV) infection is a ubiquitous sexually transmitted globally, frequently associated with sexual behaviors characterized by increased frequency and multiple partnerships. The relationship between varying levels of dietary iron intake the occurrence remains an unresolved question in scientific community. objective our study was to investigate potential consumption HPV infection. Methods Our investigation drew upon comprehensive datasets from 7,819 participants enrolled National Health Nutrition Examination Survey (NHANES) 2005 2016. Employing cross-sectional analytical framework, we delved into correlation To statistically assess this relationship, utilized weighted multivariate logistic regression models. Additionally, implemented smooth curve fitting threshold effect analysis, delineate complex, nonlinear association Furthermore, conducted subgroup analyses. Results After adjusting for confounding variables, results demonstrated significant inverse (OR = 0.988, 95% CI: 0.979–0.998, p 0.018). It’s worth noting that, comparison individuals quartile lowest intake, those highest exhibited 23.2% reduction odds each incremental unit 0.768, 0.634 0.930, 0.009). A refined analysis employing smoothing techniques unveiled L-shaped correlation, delineating specific incidence rate When <16.99 mg, higher lower intake. 0.968, 0.956–0.980, < 0.001). Conclusion presence underscores emphasizes possible beneficial sufficient reducing likelihood

Language: Английский

Citations

0
Human Papillomavirus 115 infects Yili horses DOI Creative Commons

Shuyao Tian,

Juanjuan Pan,

Da Qin

et al.

Animals and zoonoses., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanopore sequencing of non-oncogenic oral Papillomaviruses from people living with HIV DOI Creative Commons
Ian G. Munabi, Adriane Kamulegeya,

Mark Muwuluza

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Abstract Objective To explore the diversity of non-oncogenic papillomaviruses in saliva samples from people living with HIV using nanopore amplicon-based sequencing for detection and typing.Methods This was a secondary analysis data amplicons obtained polymerase chain reaction 127 HIV. The cleaned analyzed series bash, Python R scripts to produce output based on comparisons PAVE reference database all known papillomaviruses.Results A total 171,194 reads corresponding 201 papillomavirus types were data. Most these (69%), belonged human types. most abundant nonhuman PV, Trichechus manatus latirostris 4 99% samples. There nine other less that found 95% or more as mixed infections.Conclusions study demonstrates there are many PV infections PLHIV, which this setting. It is important note non-human PVs, potential one health concern, highly prevalent population.

Language: Английский

Citations

0
Metformin-induced E6/E7 inhibition prevents HPV-positive cancer progression through p53 reactivation DOI
Ruiyang Zhang, Feifei Hou,

Jianguo Gan

et al.

Anti-Cancer Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

The human papillomavirus (HPV) is implicated in multiple lethal cancers, although it more sensitive to certain therapies than HPV-negative cancers. Therefore, the development of targeted therapeutic strategies imperative. HPV oncogenes E6/E7 are ideal targets for HPV-positive cancer, but there no clinical that have been proven effectively target E6/E7. Notably, metformin significantly inhibits expression; however, underlying mechanism and potential remain unclear, limiting its translation. Cell Counting Kit-8, ethynyl-2′-deoxyuridine, terminal-deoxynucleotidyl transferase-mediated Nick end labeling assays were conducted evaluate effects on cell viability, proliferation, apoptosis. Quantitative real-time PCR, western blotting, immunofluorescence performed determine changes p53 expression levels following treatment. Patient-derived organoids in-vivo xenograft models constructed anticancer activity against cancer. Our research demonstrated enhanced sensitivity cancer cells metformin. Mechanistic studies revealed exerts by inhibiting expression, which associated with reactivation. Furthermore, we substantiated patient-derived tumor models. study focused responsiveness metformin, highlighting as a strategy

Language: Английский

Citations

0
Human Papillomavirus (HPV) Vaccination: Progress, Challenges, and Future Directions in Global Immunization Strategies DOI Creative Commons
Francesco Branda, Grazia Pavia, Alessandra Ciccozzi

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(11), P. 1293 - 1293

Published: Nov. 19, 2024

Human papillomavirus (HPV) is a widespread viral pathogen, responsible for significant burden of cervical and other cancers worldwide. Over the past decades, development adoption prophylactic HPV vaccines have dramatically reduced incidence HPV-related diseases. However, despite efficacy these vaccines, global immunization efforts still face several obstacles, including low vaccination coverage in low- middle-income countries, vaccine hesitancy, disparities access to healthcare. This review aims provide comprehensive overview current state their mechanisms action, safety profiles, real-world efficacy. We will explore impact on cancer prevention, examine challenges related distribution uptake, assess role public health policies improving rates. Additionally, highlight latest advancements therapeutic ongoing research into next-generation potential strategies context personalized medicine. By examining factors, we aim insights future directions its health.

Language: Английский

Citations

4
Risk of Cervical Carcinoma After Unfavorable Behavior and High Genetic Risk in the UK Biobank: A Prospective Nested Case–Control Study DOI Creative Commons
Shiyi Liu, Yunlong Guan, Shitong Lin

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 464 - 464

Published: Feb. 13, 2025

Background: Previous studies have established a general understanding of the association between risky sexual behavior, genetic risk, and cervical carcinoma. However, these were conducted several years ago lack systematic analysis using high-quality population-based data. Methods: We prospective nested case-control study to identify behaviors developed behavior score. Combining score we evaluated effect reproductive PRS on carcinoma through conditional logistic regression models. Results: verified increased risk in individuals with early intercourse (OR: 1.41 [95% CI 1.09 1.83], p = 0.0083), non-monogamous partners 3.13 2.15 4.57], < 0.0001), three or more live births 1.44 1.12 1.84], 0.0040), high (polygenic score) (top 25% PRS, OR: 1.58 1.15 2.16], 0.0044). The unfavorable was linked 151% 2.51 1.79 3.52], 0.0001) after adjusting for PRS. Women both had 5.5-fold 5.45 2.72 10.95], compared favorable low risk. Conclusions: Unfavorable increases carcinoma, especially those These findings encourage us adhere healthy pattern.

Language: Английский

Citations

0
Smartphone-based urine colourimetric assay for home self-screening of HPV infection DOI
Xiaoli Zhang, Zhaoguang Wang, Jing Yang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125923 - 125923

Published: Feb. 19, 2025

Language: Английский

Citations

0