New Thiophene–Butanol Derivatives: Synthesis, Spectroscopic Characterization, DFT, Biological Activities and In Silico Study DOI

Reşat Ustabaş,

Nevin Süleymanoğlu, Fatih Çelik

et al.

Russian Journal of Physical Chemistry A, Journal Year: 2023, Volume and Issue: 97(11), P. 2488 - 2500

Published: Nov. 1, 2023

Language: Английский

I2/p-TSA: An efficient reagent for regioselective synthesis of angularly fused diazabenzocyclo-pentafluorene via iodocyclisation of 11-(arylethynyl)-11H-indeno[1,2-b]quinoxalin-11-ol DOI

Ammundi Jayavel Chirranjeevi Padmashrija,

Sathananthan Kannadasan,

Ponnusamy Shanmugam

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: 156, P. 155448 - 155448

Published: Jan. 4, 2025

Language: Английский

Citations

0
Novel benzothiophene based catalyst with enhanced activity for glucose electrooxidation DOI

Omrüye Ozok,

Emrah Kavak, Ömer Faruk Er

et al.

International Journal of Hydrogen Energy, Journal Year: 2020, Volume and Issue: 45(53), P. 28706 - 28715

Published: Aug. 12, 2020

Language: Английский

Citations

24
Synthesis, Biological Evaluation and Molecular Docking of Novel Thiophene‐Based Indole Derivatives as Potential Antibacterial, GST Inhibitor and Apoptotic Anticancer Agents DOI
Metin Konuş, Doğan Çetin, Can Yılmaz

et al.

ChemistrySelect, Journal Year: 2020, Volume and Issue: 5(19), P. 5809 - 5814

Published: May 20, 2020

Abstract Heteroaromatic indoles play a leading role in the development of pharmaceutical, medical, chemical and agricultural fields due to their structural properties. In this study, it was first time that biological properties (antioxidant, antimicrobial, cytotoxic apoptotis‐induced anticancer) 3‐(5‐bromothiophen‐2‐yl)‐1‐ethyl‐2‐phenyl‐1H‐indole 4 3‐([2,2′‐bithiophen]‐5‐yl)‐1‐ethyl‐2‐phenyl‐1H‐indole 5 were described. According overall results, while did not show any significant cytotoxic, antioxidant antimicrobial activities, showed high reducing activity very strong antibacterial against Enterococcus faecalis . Furthermore, dose‐dependent effect all tested cell lines. The EC 50 values found be 16 μM for CaCo‐2, 29 LnCaP, 14 MDA‐MB231, 21 HepG2 87 HEK293 cells, respectively. also caused induction apoptosis promising glutathione S‐transferase (GST) enzyme inhibition cells. Consequently, could considered as medical agent cancer treatment.

Language: Английский

Citations

23
New Schiff Bases with Thiophene Ring: Synthesis, Biological Activities, and Molecular Docking Study DOI
Fatih Çelik, Kadriye İnan, Halil İbrahim Güler

et al.

Russian Journal of General Chemistry, Journal Year: 2023, Volume and Issue: 93(2), P. 409 - 417

Published: Feb. 1, 2023

Language: Английский

Citations

6
Synthesis, Optimization, ADME Analysis, and Antioxidant Activity of 2-(Arylethynyl)-3-ethynylthiophenes DOI
Emrah Kavak,

Muheb Algso,

Metin Konuş

et al.

Russian Journal of Organic Chemistry, Journal Year: 2021, Volume and Issue: 57(1), P. 91 - 99

Published: Jan. 1, 2021

Language: Английский

Citations

6
Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules DOI
Aslıhan Kurt‐Kızıldoğan, Çiğdem Otur, Can Yılmaz

et al.

Letters in Drug Design & Discovery, Journal Year: 2020, Volume and Issue: 18(5), P. 461 - 470

Published: Nov. 11, 2020

Aim: In this study experiments were carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1Hindole (EPI) together with its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Background:: Indoles probably represent one the most important heterocyclic structures that have been attracting interest many scientists drug discovery. Objective: The present was 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole and Materials Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial GST enzyme activity test. Results: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant antimicrobial properties. It displayed significant induction cancer cell lines (HepG2), but all tested could not be observed. Conclusion:: All these results showed without effect, which make it a promising active component further studies.

Language: Английский

Citations

4
Study of the iodine-promoted cyclization of 4,5-diethynyl-1,2,3-triazoles for the synthesis of triazole-iodoheterocyclic dyads DOI
Anastasia I. Govdi,

K. V. Kimele,

Ирина А. Балова

et al.

Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(11), P. 3318 - 3323

Published: Nov. 1, 2024

Language: Английский

Citations

0
Pd-, Cu-, and Ni-Catalyzed Reactions: A Comprehensive Review of the Efficient Approaches towards the Synthesis of Antibacterial Molecules DOI Creative Commons

Almeera Zia,

Shehla Khalid, Nasır Rasool

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1370 - 1370

Published: Oct. 15, 2024

A strong synthetic tool for many naturally occurring chemicals, polymers, and pharmaceutical substances is transition metal-catalyzed synthesis. serious concern to human health the emergence of bacterial resistance a broad spectrum antibacterial medications. The synthesis chemical molecules that are potential candidates underway. main contributions medicine found be effective in metal catalysis heterocyclic chemistry. This review underlines use heterocycles certain metals (Pd, Cu, Ni) as catalysts methods compounds. Pharmaceutical chemists might opt clinical exploration these techniques due their potential.

Language: Английский

Citations

0
1-(3-Methylthiophene-2-yl)-N-(3,4,5-trimethoxyphenyl)­methanimine: Synthesis, Spectroscopic Characterization, Antileishmanial Activity, and DFT and In Silico Studies DOI
Meryem Evecen, Fatih Çelik, Halil İbrahim Güler

et al.

Russian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 60(9), P. 1799 - 1809

Published: Sept. 1, 2024

Language: Английский

Citations

0
A Thiophene Derivative, 2‐Bromo‐5‐(2‐(methylthio)phenyl)thiophene, Has Effective Anticancer Potential with Other Biological Properties DOI
Can Yılmaz, Ahmed Othman Pirdawid, Ceylan Fidan Babat

et al.

ChemistrySelect, Journal Year: 2022, Volume and Issue: 7(15)

Published: April 19, 2022

Abstract Thiophene derivatives are studied intensively due to their anticancer, antimicrobial, antioxidant and some other clinically important properties. In this study, the biological properties of a new thiophene derivative, so called BMPT , with moderate drug score 0.29 were tested. showed selective cytotoxicity for LnCap, HepG2 Caco‐2 cancer cell lines EC 50 values 138.573 μM, 185.931 108.657 respectively, but not on control line HEK293. The increased expressions detected caspase3, caspase8, caspase9 Bax; Bcl‐2 decreased at lines. total thiol content GST activities 47 % 40 %, and, molecular docking supported inhibitory models GSTP1‐1, GSTA1‐1 GSTM2‐2 mixed, uncompetitive uncompetitive, respectively. also potent antibacterial activity against Staphylococcus aureus . Related its inhibition activities, is proposed have significant apoptotic effect leaded by changes, especially, in caspase 3, Bax expressions.

Language: Английский

Citations

2