Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review

RSC Advances, Journal Year: 2024, Volume and Issue: 14(25), P. 18011 - 18063

Published: Jan. 1, 2024

This literature update is a continuation of our efforts to compile comprehensive data on research endeavors concerning acyl thioureas over the past two years.

Language: Английский

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The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 2103 - 2118

Published: April 1, 2024

Diabetic kidney disease (DKD), is a common microvascular complication and major cause of death in patients with diabetes.Disorders immune cells cytokines can accelerate DKD development number ways.As the composed complex highly differentiated cells, interactions among different cell types play important regulatory roles development.Here, we summarize latest research into molecular mechanisms underlying various renal DKD.In addition, discuss most recent studies related to single technology bioinformatics analysis field DKD.The aims our review were explore as potential therapeutic targets provide some guidance for future clinical treatments.

Language: Английский

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Acyl Thiourea Derivatives: Versatile Tools for Chemosensing and Heavy Metal Remediation

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 114279 - 114279

Published: Oct. 1, 2024

Language: Английский

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Anti‐inflammatory Potential of 1,4‐Naphthoquinone Acyl Thiourea Hybrids on Lipopolysaccharide‐Activated Mammalian Macrophages, and Their Acid Dissociation Constants

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(20)

Published: May 24, 2023

Abstract In this study, seven new and known 1,4‐naphthoquinone acyl thiourea hybrids were synthesized their molecular structures confirmed by various analytical methods. These derivatives tested for anti‐inflammatory potential on the murine macrophages. Pro‐inflammatory cytokine production levels cell viabilities compared between groups with LPS positive control to determine most potent drug candidate. Our results suggest that these had activity without exerting major cytotoxicity. Their future evaluation in inflammatory autoimmune disease settings will be crucial possible utilization clinical setting. The acid dissociation constants of 1 – 7 determined potentiometrically at 25.0±0.1 °C, an ionic strength 0.1 M NaCl 20 % (v/v) DMSO water hydro‐organic solvent mixture acidic medium. Three calculated each hybrid HYPERQUAD computer program using data obtained as a result potentiometric titrations under specified conditions.

Language: Английский

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Protective effect of bromelain on some metabolic enzyme activities in tyloxapol‐induced hyperlipidemic rats

Biotechnology and Applied Biochemistry, Journal Year: 2023, Volume and Issue: 71(1), P. 17 - 27

Published: Sept. 25, 2023

Abstract Elevation of one or more plasma lipids, such as phospholipids, cholesterol esters, cholesterol, and triglycerides, is known hyperlipidemia. In humans experimental animals, bromelain, the primary active ingredient isolated from pineapple stems, has several positive effects, including anti‐tumor growth, anticoagulation, anti‐inflammation. Hence, purpose this study was to determine possible protective impact bromelain on some metabolic enzymes (paraoxonase‐1, glutathione S ‐transferase, reductase, sorbitol dehydrogenase [SDH], aldose reductase [AR], butyrylcholinesterase [BChE], acetylcholinesterase [AChE]), activity in heart, kidney, liver rats with tyloxapol‐induced Rats were divided into three groups: control group, HL‐control group (tyloxapol 400 mg/kg, i.p. administered group), HL+bromelain (group receiving 250 mg/kg/o.d. prior administration tyloxapol i.p.). BChE, SDH, AR enzyme activities significantly increased all tissues compared control, whereas other studied decreased. Bromelain had a regulatory effect activities. conclusion, these results prove that new mediator decreases

Language: Английский

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Selectivity Challenges for Aldose Reductase Inhibitors: A Review on Comparative SAR and Interaction Studies

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139207 - 139207

Published: July 4, 2024

Language: Английский

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Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension

BMC Complementary Medicine and Therapies, Journal Year: 2023, Volume and Issue: 23(1)

Published: May 6, 2023

Abstract Background Oxidative stress and endothelial cell dysfunction induced by high-altitude hypoxia have important roles in the pathological process of pulmonary hypertension (HAPH). Tannins present Terminalia bellirica (Gaertn.) Roxb. (TTR) pharmacological activities that produce oxidation resistance exert anti-inflammatory effects. Whether TTR exerts a protective effect on HAPH remains unknown. Methods A rat model was established. The mean arterial pressure (mPAP) animals measured, serum levels SOD, MDA, GSH-Px were measured using ELISA, expression Bax, Bcl-2, Nrf2, HO-1 proteins lung tissue each group rats Western blotting. Pathological changes also observed. damage to H 2 O -induced artery cells (PAECs) generated, proliferation CCK-8 assays. Flow cytometry used measure ROS PAECs. blotting detect Results hemodynamic pathologic findings showed mPAP increased markedly, vascular wall thickness ( P < 0.05). reduced mPAP, alleviated or slowed remodeling, SOD activity, lowered level MDA 0.05), downregulated Bax tissues rats, while upregulated results experiments inhibited PAEC apoptosis production PAECs, Conclusion suggest reduces pressure, decreases oxidative during HAPH, effects with its mechanism action is related regulation Nrf2/HO-1 signaling pathway.

Language: Английский

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Comprehensive Analysis of Fatty Acid Metabolism in Diabetic Nephropathy from the Perspective of Immune Landscapes, Diagnosis and Precise Therapy

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 693 - 710

Published: Feb. 1, 2024

Objective: Diabetic nephropathy (DN) represents the principal cause of end-stage renal diseases worldwide, lacking effective therapies. Fatty acid (FA) serves as primary energy source in kidney and its dysregulation is frequently observed DN. Nevertheless, roles FA metabolism occurrence progression DN have not been fully elucidated. Methods: Three datasets (GSE96804/GSE30528/GSE104948) were obtained combined. Differentially expressed metabolism-related genes identified subjected to classification using “ConsensusClusterPlus”. subtypes-associated modules discovered by “WGCNA”, module underwent functional enrichment analysis. The immune landscapes potential drugs analyzed “CIBERSORT” “CMAP”, respectively. Candidate diagnostic biomarkers screened machine learning algorithms. A prediction model was constructed, performance assessed receiver operating characteristic (ROC) curves, calibration decision curve analysis (DCA). online tool “Nephroseq v5” conducted reveal clinical significance candidate patients with mouse established verify biomarkers’ expression. Results: According 39 dysregulated genes, samples divided into two molecular subtypes. Patients Cluster B exhibited worse outcomes a different landscape compared those A. Ten small-molecular predicted treat B. based on PRKAR2B/ANXA1 created ideal predictive values early advanced stages correlation revealed significant association between characteristics. validated expression patterns PRKAR2B/ANXA1. Conclusion: Our study provides new insights role classification, immunological pathogenesis, diagnosis, precise therapy Keywords: diabetic nephropathy, fatty metabolism, subtypes, landscape, pharmacotherapy,

Language: Английский

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Association of Apolipoprotein E Gene Polymorphism with Type 2 Diabetic Nephropathy in the Southern Chinese Population

International Journal of General Medicine, Journal Year: 2023, Volume and Issue: Volume 16, P. 5549 - 5558

Published: Nov. 1, 2023

Background: Common polymorphisms within the apolipoprotein E (APOE) gene are rs429358 and rs7412, which result in three major alleles (ɛ2, ɛ3, ɛ4) six genotypes (E2/E2, E2/E3, E3/E3, E3/E4, E4/E4, E2/E4).Although APOE have been suggested to be associated with development of diabetic nephropathy (DN), their potential association remains unclear different regions.This study aims unveil genetic effects on DN susceptibility serum lipid profiles southern Chinese population.Methods: A total 306 patients 483 type 2 as controls were included study.The analyzed by polymerase chain reaction (PCR) microarray chip.Relevant medical records information these participants collected.Results: There statistically significant differences (p < 0.05) gender, SBP, hypertension, hyperuricemia, UTP, TG HDL-C between controls.DN exhibited a higher frequency ε2 allele E2/E3 genotype than 0.001).Logistic regression analysis indicated that independent risk factors (adjusted OR: 3.237, 95% CI: 1.789-5.854,p 0.001; adjusted 3.453, 1.873-6.368,p 0.001), while ε3 or E3/E3 might serve protective role 0.395, 0.255-0.612,p 0.001) for DN. Conclusion:Our indicates correlation Hakka population.Specifically, individuals carrying at developing DN.Conversely, those lower population.

Language: Английский

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The Effects of Apigenin in the Treatment of Diabetic Nephropathy: A Systematic Review of Non-clinical Studies

Mini-Reviews in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 24(3), P. 341 - 354

Published: Oct. 15, 2023

Diabetes is one of the important and growing diseases in world. Among most common diabetic complications are renal adverse effects. The use apigenin may prevent development progression diabetes-related injuries. current study aims to review effects treatment nephropathy.

Language: Английский

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