Biological Activities of Galanthus fosteri Extracts: First Demonstration of the Interaction between Chlorogenic Acid and DNA Ligase by Molecular Docking DOI Creative Commons
Safiye Elif Korcan, Nevin Çankaya, İbrahim Bulduk

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(10), P. 12254 - 12261

Published: Feb. 23, 2024

Within the Amaryllidaceae family, bulbous plant species Galanthus fosteri (G. fosteri) belongs to genus. Alkaloids with a broad variety of biological functions are typically found in flora this family. The G. plant's organs' antioxidant activity, antibacterial impact, and antimicrobial qualities were examined study. Total flavonoid contents (TFC) total phenolic (TPC) extracts measured spectrophotometric methods, activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging technique. HPLC method used determine compounds on component basis. properties assessed Kirby−Bauer disc diffusion method, minimum inhibitory concentration against pathogens Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli. Additionally, combination tests performed between extract antibiotics. Leaf stem demonstrated greater than bulb extracts, despite fact that organs did not exhibit appreciable levels TPC, TFC, or qualities. According analysis results, it chlorogenic acid present all extracts. In fact, only 8.02 (mg/10 g) peel, which has properties. A molecular docking study for first time effect might be due DNA replication inhibition.

Language: Английский

The Anti-Inflammatory Activity of Viscum album DOI Creative Commons
Marcello Nicoletti

Plants, Journal Year: 2023, Volume and Issue: 12(7), P. 1460 - 1460

Published: March 27, 2023

The therapeutic story of European mistletoe (

Language: Английский

Citations

38
Anticholinesterase and carbonic anhydrase inhibitory activities of natural carnosic acid derivatives: A comprehensive in vitro and in silico study DOI Creative Commons
Zeynep Köksal, Halil Şenol

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract This study investigates the anticholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BChE]) carbonic anhydrase (CAI CAII) inhibitory activities of carnosic acid its natural derivatives, including carnosol, rosmanol, 7‐methoxy‐rosmanol, 12‐methoxy‐carnosic acid, isorosmanol. Among tested compounds, rosmanol demonstrated exceptional potency, with IC 50 values 0.73 nM for AChE 0.75 BChE, significantly outperforming tacrine. Rosmanol also exhibited remarkable inhibition CA I (IC = 0.21 nM), surpassing acetazolamide by over 450‐fold, moderate CAII. Molecular docking molecular mechanics generalized born surface area (MM‐GBSA) studies revealed strong binding affinities scores −11.757 kcal/mol (AChE) −11.465 (BChE). The MM‐GBSA free energy calculations further confirmed stable interactions (−63.24 kcal/mol) (−60.09 kcal/mol). dynamics simulations ns showed enzyme‐ligand complexes, particularly BChE (root mean square deviation ~1.5 Å), key residues identified as crucial stabilization. Other derivatives displayed significant activities, suggesting their potential secondary leads. ADMET analysis favorable pharmacokinetics emerged a promising candidate. comprehensive highlights multitarget therapeutic agent potent properties, offering promise treating neurodegenerative metabolic disorders.

Language: Английский

Citations

0
Antioxidant, Antidiabetic, and Antimicrobial Potentials of Silver Nanoparticles Synthesized from Viscum album DOI

Ebru Çöteli

Tarım Bilimleri Dergisi, Journal Year: 2025, Volume and Issue: 31(2), P. 373 - 391

Published: March 25, 2025

Substances smaller than 100 nm in size are called nanoparticles. In this study silver nanoparticle synthesis was carried out by using AgNO3 from leaf, fruit, and branch aqueous extracts of the mistletoe (Viscum album ssp. austriacum) plant. It determined whether nanoparticles were formed UV-Vis method. As a result analysis plant parts, peaks observed at 425, 427, 430 nm, indicating surface plasmon resonance AgNPs. Specific functional groups involved formation AgNPs reduction Ag FT-IR spectroscopy. SEM EDS analyses that synthesized samples nanosized, average 59.91. addition to crystallite calculated XRD diffraction, it all obtained nanometer range, same as pure silver. Considering antioxidant results study, highest total phenolic flavonoid amounts leaf extract (35.57±1.39 mg GAE/g extract) fruit (23.42±1.29 QE), respectively. Additionally, radical scavenging activity sample (IC50 129.24±1.38 μg/mL). antidiabetic (α-amylase inhibition) 123.59±1.44 result, these parts had superior antioxidant, antidiabetic, antimicrobial properties.

Language: Английский

Citations

0
The Antioxidant Activity of Mistletoes (Viscum album and Other Species) DOI Creative Commons
Marcello Nicoletti

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2707 - 2707

Published: July 20, 2023

In addition to the European mistletoe,

Language: Английский

Citations

8
Antioxidant Properties and Aldose Reductase Inhibitory Potency of Viscum album L. Extracts: Experimental and Computational Insights DOI Open Access
Bilal Akyüz, Bülent Şengül

TURKISH JOURNAL OF AGRICULTURE AND FORESTRY, Journal Year: 2024, Volume and Issue: 48(2), P. 305 - 316

Published: April 1, 2024

This study systematically investigates the antioxidant capacity and inhibitory impact of Viscum album L. plant extracts on aldose reductase (AR) enzyme through a combined approach in vitro silico methods. Various sections derived from distinct parts were examined, revealing potent potential. Notably, methanol extract sourced plant's stem displayed remarkable efficacy with an IC50 value 0.156 µM. Total phenolic content analyses conducted, highlighting variations across solvent types. Qualitative quantitative compounds was also elucidated by LC-MS/MS analysis it determined that had higher Quinic Acid, Fumaric Chlorogenic Acid contents. Molecular docking studies further substantiated roles key like chlorogenic acid fumaric acid. Their interactions specific amino residues within AR enzyme's active site elucidated, shedding light underlying mechanisms. Collectively, this underscores as promising candidates for modulation. By merging experimental computational techniques, presents holistic understanding natural compound interactions, potentially influencing drug development herbal therapeutics.

Language: Английский

Citations

2
Biological Activities of Galanthus fosteri Extracts: First Demonstration of the Interaction between Chlorogenic Acid and DNA Ligase by Molecular Docking DOI Creative Commons
Safiye Elif Korcan, Nevin Çankaya, İbrahim Bulduk

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(10), P. 12254 - 12261

Published: Feb. 23, 2024

Within the Amaryllidaceae family, bulbous plant species Galanthus fosteri (G. fosteri) belongs to genus. Alkaloids with a broad variety of biological functions are typically found in flora this family. The G. plant's organs' antioxidant activity, antibacterial impact, and antimicrobial qualities were examined study. Total flavonoid contents (TFC) total phenolic (TPC) extracts measured spectrophotometric methods, activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging technique. HPLC method used determine compounds on component basis. properties assessed Kirby−Bauer disc diffusion method, minimum inhibitory concentration against pathogens Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli. Additionally, combination tests performed between extract antibiotics. Leaf stem demonstrated greater than bulb extracts, despite fact that organs did not exhibit appreciable levels TPC, TFC, or qualities. According analysis results, it chlorogenic acid present all extracts. In fact, only 8.02 (mg/10 g) peel, which has properties. A molecular docking study for first time effect might be due DNA replication inhibition.

Language: Английский

Citations

1