Recent Advances in The Electrochemical Functionalization of N-heterocycles DOI
Manoj Kumar Yadav, Sushobhan Chowdhury

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The review aims to provide a clear picture of the possible electron transfer pathways, electrochemical behavior different N-heterocycles, and functionalization reagents achieve desired functionalization/modification N-heterocycles.

Language: Английский

Arylation of α‐Imino Ketones and their Cyclization with Allenoates: Direct Access to Sterically Hindered Pyrroles DOI Open Access
Srinivasarao Yaragorla,

Doma Arun

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Herein, we report a calcium‐catalyzed, one‐pot, four‐component reaction to synthesize diversely substituted pyrroles. This atom‐economy involves sequence of reactions that proceed via in situ formation α ‐ imino ketones, Friedel‐Crafts arylation, aza‐cyclization, and aromatization the single pot. The showed broad substrate scope with good yields. We demonstrated gram‐scale synthesis post‐synthetic modifications.

Language: Английский

Citations

1
Pd-Catalyzed Decarbonylative sp2 C–H Arylation: Construction of Five- and Six-Membered (Hetero)Cyclic Compounds DOI
Shan‐Shan Zhang,

Mengjie Cen,

Chenglong Li

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(22), P. 4660 - 4665

Published: May 24, 2024

The cyclic compounds have wide applications in the design and synthesis of drugs materials; thus, their efficient construction attracts much attention from synthetic community. In this letter, we report an method for preparing starting readily available carboxylic acids. This reaction takes place through intramolecular decarbonylative sp2 C–H arylation, enabling a range five- six-membered compounds. Both carbo- heterocycles can be produced under conditions. Moreover, features substrate scope with high functional group tolerance. scale-up experiments also show its practicality organic synthesis. Those experimental results indicate that would find

Language: Английский

Citations

6
Enantioselective Palladium-Catalyzed Domino Carbonylative Heck Esterification of o-Iodoalkenylbenzenes with Arylboronic Acids DOI

Yaodu Zhang,

Ming Chen, Yang Li

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(45), P. 8110 - 8115

Published: Nov. 3, 2023

The current investigation presents an innovative palladium-catalyzed asymmetric carbonylative Heck esterification method. This approach facilitates the efficient synthesis of various chiral γ-ketoacid esters by utilizing o-alkenyliodobenzenes and arylboronic acids as primary substrates. reaction achieves creation three carbon–carbon bonds, two carbon–oxygen establishment a quaternary carbon center within single step. α-chiral were obtained in yields ranging from good to high yields, displaying enantiomeric excesses (ee's) levels up 92% under mild conditions.

Language: Английский

Citations

10
Recent advances in cyclization reactions via catalytic allylic substitution for the asymmetric synthesis of heterocyclic compounds DOI
Bendu Pan,

Chitreddy V. Subba Reddy,

Yunru Wu

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 141, P. 155071 - 155071

Published: April 17, 2024

Language: Английский

Citations

3
Mechanistic Analysis of Diverse Click reactions along with their Applications DOI

Souful Bhatia,

Avadh Biharee, Souren Mondal

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117800 - 117800

Published: May 1, 2025

Language: Английский

Citations

0
“In-Water” Three-Component One-Pot Reaction for the Facile Synthesis of Densely Functionalized 2,3-Dihydro-1H-pyrrol-2-ols and Mechanistic Insight DOI

Saigal Saigal,

Nallakantham Sudheer,

Subash C. Sahoo

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(35), P. 13336 - 13351

Published: Aug. 22, 2024

An environmentally friendly multicomponent reaction strategy for the synthesis of functionally rich all-carbon substituted 2,3-dihydro-1H-pyrrol-2-ols "in-water" at room temperature has been reported. Water plays an indispensable role in presence readily available catalytic surfactants sodium dioctylsulfosuccinate and dodecyl sulfate to effectuate transformation, as proved by inferior results obtained organic solvents. A wide display substrate scope functional group compatibility permits diversity generation a mild operationally simple fashion. High product yields, fast rate, recoverability/recyclability catalysts, high TON/TOF, ease purification final products filtration, AE values, excellent E-factor count with score low possible highlight "greenness" this approach. Feasibility "gram-scale" synthetic elaboration offer notable advantages. The mechanistic understanding intercepting labile "imine" intermediate realized through sequence imine formation Mannich-type followed intramolecular N-cyclization.

Language: Английский

Citations

3
Recent Advances in The Electrochemical Functionalization of N-heterocycles DOI
Manoj Kumar Yadav, Sushobhan Chowdhury

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The review aims to provide a clear picture of the possible electron transfer pathways, electrochemical behavior different N-heterocycles, and functionalization reagents achieve desired functionalization/modification N-heterocycles.

Language: Английский

Citations

0