Primula
veris
subsp,
or
commonly
known
as
the
"half
herb"
plant,
is
a
perennial
plant
subspecies
belonging
to
Primulaceae
family.
This
generally
found
in
temperate
climatic
regions,
especially
Europe.
Its
leaves
are
heart-shaped
and
usually
basal
rosettes.
One
of
notable
features
half-herb
its
lily-like
flowers.
The
flowers
light
yellow
color
offer
an
eye-catching
beauty.
this
bloom
early
spring
grow
naturally
locally.
It
has
also
been
used
traditional
medicine
relation
some
herbs,
but
more
information
needed
about
medicinal
uses
thought
be
effective
cancer
treatment.
There
have
several
documented
investigations
on
identification
plant's
biological
potential.
Chemical
components
were
determinated
for
subs
Plant
extract,
inhibitory
activities
these
chemicals
against
Crystal
structure
breast
protein
(PDB
ID:
1A52
1JNX)
downloaded
from
Protein
Data
Bank
site
compared.
Food Chemistry X,
Journal Year:
2025,
Volume and Issue:
25, P. 102125 - 102125
Published: Jan. 1, 2025
The
present
study
reveals
in
vitro
antioxidant
properties
and
the
phytochemical
content
of
a
novel
Rheum
species
(Rheum
telianum),
which
grows
Southeastern
Anatolia.
To
perform
analysis,
dried
leaves
seeds
plants
were
ground
extracted
with
ethanol
to
obtain
plant
secondary
metabolites
activity.
Then,
extracts
subjected
DPPH
scavenging
Cupric
reducing
(CUPRAC),
Fe3+,
Ferric
power
(FRAP).
In
addition
capacity
assays,
quantitative
phenolic,
flavonoid,
metabolite
determined
through
spectrophotometric
LC-MS/MS
chromatographic
methods.
IC50
values
showed
that
both
R.
telianum
have
high
inhibitory
over
radicals
20.79
5.67
μg/mL,
respectively.
samples'
dominant
evaluated
analysis
results.
inhibition
effects
on
acetylcholinesterase
butyrylcholinesterase,
α-glycosidase
human
carbonic
anhydrases
II
isoenzyme
enzymes,
associated
some
global
diseases
including
Alzheimer's
disease,
type-2
diabetes
mellitus
glaucoma
determined.
conclusion,
extracts'
contents
functional
relationship
plants'
possible
usage
food,
medicine,
cosmetic
industries
was
revealed.
Zeitschrift für Naturforschung C,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
Abstract
A
new
series
of
hydrazone
derivatives
(
1a-1l
)
were
prepared
from
a
condensation
reaction
between
different
hydrazide
and
3-formylbenzoic
acid.
Through
the
use
several
spectral
techniques,
such
as
1
H-NMR,
13
C-NMR,
elemental
analysis,
structures
compounds
clarified.
The
crystal
structure
compound
1d
was
obtained
by
single-crystal
X-ray
crystallography.
They
found
to
have
inhibitory
effects
on
anticancer
potentials
human
carbonic
anhydrase
isoforms
I
II.
Compound
be
strongest
inhibitor,
with
IC
50
values
0.133
µM
against
hCA
I.
Also,
1l
showed
highest
activity
3.244
Moreover,
their
cytotoxic
rat
glioma
cell
colon
adeno
carcinoma
lines
evaluated.
According
cytotoxicity
results,
1j
exhibited
HT29
cell,
while
1e
,
1g,
effect
C6
line.
which
carries
methoxy
substituent
at
3
rd
position
phenyl
ring,
effective
both
cancer
cells
ADME/T
properties
molecular
docking
molecules
examined.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(19)
Published: May 16, 2024
Abstract
Several
of
3,4,5,6‐tetrahydropyrimidinium
salts
with
1‐methyl
functionalization
are
produced.
By
using
techniques
for
1
H‐NMR,
13
C‐NMR,
and
IR
spectroscopy,
all
compounds
were
investigated.
Additionally,
these
compounds’
abilities
to
block
enzymes
looked
into.
They
had
a
highly
effective
inhibitory
effect
on
the
isoenzymes
carbonic
anhydrases
I
II,
butyrylcholinesterase
(BChE),
acetylcholinesterase
(AChE).
K
i
values
found
in
range
57.43±7.09–170.09±50.91
nM
AChE,
7.19±0.42–69.08±2.44
BChE,
46.48±5.74–203.38±46.15
hCA
I,
30.19±4.03–171.96±30.27
II.
As
result,
1,3‐disubtitituted
tetrahydroprimidinium
exhibited
potent
inhibition
profiles
toward
indicated
metabolic
enzymes.
One
most
important
methods
designing
creating
novel,
medications
treat
Alzheimer's
disease
(AD)
worldwide
is
synthesis
discovery
new
AChE
BChE
inhibitors.
The
activities
synthesized
compared
against
various
proteins
that
crystal
structure
(PDB
ID:
4
M0E),
5NN0),
2CAB),
II
3DC3),
then
drug
properties
molecules
examined.
