A comprehensive review of multi-target directed ligands in the treatment of Alzheimer’s disease

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 144, P. 107152 - 107152

Published: Jan. 27, 2024

Language: Английский

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The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons

Brain Research, Journal Year: 2024, Volume and Issue: 1829, P. 148797 - 148797

Published: Feb. 10, 2024

Language: Английский

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Quinoline–sulfonamides as a multi-targeting neurotherapeutic for cognitive decline:in vitro,in silicostudies and ADME evaluation of monoamine oxidases and cholinesterases inhibitors

RSC Advances, Journal Year: 2024, Volume and Issue: 14(13), P. 8905 - 8920

Published: Jan. 1, 2024

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder with multiple enzymes involved.

Language: Английский

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Chromatographic Analysis and Enzyme Inhibition Potential of Reynoutria japonica Houtt.: Computational Docking, ADME, Pharmacokinetic, and Toxicokinetic Analyses of the Major Compounds

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 408 - 408

Published: March 14, 2025

Background: Reynoutria japonica Houtt. has been used for inflammatory diseases, skin burns, and high cholesterol in traditional Chinese medicine, the roots rhizomes of plant were registered Pharmacopoeia. This study evaluated enzyme inhibitory activities R. extracts from Türkiye. Its major phytochemical content was elucidated, molecular interaction studies main compounds conducted, toxicokinetic predictions absorption, distribution, metabolism, elimination performed with silico methods. Methods: tested their using an ELISA microplate reader. The profile elucidated by LC-MS QTOF. Docking other interactions its components cholinesterase, collagenase, elastase. Results: exhibited significant cholinesterase effectiveness, while stem root showed moderate tyrosinase inhibition. leaf (IC50 = 117.20 ± 4.84 g/mL) flower 111.40 1.45 µg/mL) considerable elastase activity. 171.00 6.76 160.00 6.81 displayed similar potent collagenase In QTOF analysis, procyanidin dimer, catechin, piceid, torachrysone, glucoside isomers identified as resveratrol minor component. Galloylglucose strongest binding at via key hydrogen bonds, emodin-6-glucoside emodin formed stable Piceid polar water-mediated contacts collagenase. These findings underscore potential these ligands protein inhibitors. reveal that possessed most favorable drug-like properties but posed risks. Conclusions: research represents first investigation bioactivity phytochemistry grown documented 2020 Our point out could be cosmetic purposes, further on neurological disorders performed.

Language: Английский

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Specific Rosetta-based protein-peptide prediction protocol allows the design of novel cholinesterase inhibitor peptides

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108202 - 108202

Published: Jan. 22, 2025

Language: Английский

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In silico exploration of Aloe Vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy

Current Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Peptidomimetics based on ammonium decasubstituted pillar[5]arenes: Influence of the alpha-amino acid residue nature on cholinesterase inhibition

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 141, P. 106927 - 106927

Published: Oct. 19, 2023

Language: Английский

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Chemical characterization and biological properties of oyster and shiitake mushrooms extracts and their liposomal formulations.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104737 - 104737

Published: July 14, 2024

Language: Английский

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Epigenetic Biomarkers in Alzheimer's Disease: Diagnostic and Prognostic Relevance

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102556 - 102556

Published: Oct. 30, 2024

Language: Английский

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β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8164 - 8164

Published: May 3, 2023

The β-secretase-1 enzyme (BACE-1) performs a key role in the production of beta-Amyloid protein (Aβ), which is associated with development Alzheimer’s disease (AD). inhibition BACE-1 has been an important pharmacological strategy treatment this neurodegenerative disease. This study aims to identify new potential candidates for help silico studies, such as molecular docking and ADME prediction, from broad list provided by DrugBank database. From analysis, 1145 drugs capable interacting higher coupling energy than Verubecestat were obtained, subsequently only 83 presented EJ7. Applying oral route administration inclusion criteria, 41 met requirement; however, 6 them are diagnostic tests not treatment, so 33 obtained. Finally, five identified possible inhibitors drugs: Fluphenazine, Naratriptan, Bazedoxifene, Frovatriptan, Raloxifene. These exhibit pharmacophore-specific features, including indole or thioindole group, interactions amino acids BACE-1. Overall, provides insights into use methods drug repurposing identification disease, especially those targeting

Language: Английский

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