Studying the Characteristics of Curcumin-Loaded Liposomal Nanoparticles DOI Creative Commons

Iman Afyouni,

Parizad Ghanbarikondori,

Niki Sadeghi Pour

et al.

Asian Pacific Journal of Cancer Biology, Journal Year: 2024, Volume and Issue: 9(2), P. 183 - 189

Published: May 29, 2024

Overview: In this study, the physical and chemical properties of curcumin are extensively examined when it is incorporated into liposome nanoparticles, to enhance its therapeutic potency bioavailability. Curcumin, a plant-derived polyphenol, has garnered attention for anti-inflammatory, antioxidant, anti-cancer activities. However, clinical utility hindered by several limitations, including poor water solubility, inadequate absorption, rapid metabolism. By leveraging potential nanoparticles improve drug delivery efficacy, research aims overcome these obstacles unlock full curcumin. Methods: Curcumin-loaded (CLLNs) were fabricated employing thin-film hydration method, after sonication. The physicochemical attributes CLLNs subsequently characterized, encompassing particle size zeta assessment utilizing dynamic light scattering (DLS), encapsulation efficiency (EE%) loading (DLE%) determination through high-performance liquid chromatography (HPLC), investigation in vitro release patterns simulated biological fluids. Results: optimized study had mean diameter less than 250 nm negative surface charge, implying good stability cellular uptake. both found be high, indicating that was effectively loaded liposomes. testing showed sustained pattern from CLLNs. Conclusion: offered important observations about advantageous features curcumin-loaded highlighting their as cutting-edge system demonstrated have high efficiencies, well controlled improved stability, which suggests ability benefits These findings set stage future vivo trials fully investigate medical applications.

Language: Английский

Studying the Characteristics of Curcumin-Loaded Liposomal Nanoparticles DOI Creative Commons

Iman Afyouni,

Parizad Ghanbarikondori,

Niki Sadeghi Pour

et al.

Asian Pacific Journal of Cancer Biology, Journal Year: 2024, Volume and Issue: 9(2), P. 183 - 189

Published: May 29, 2024

Overview: In this study, the physical and chemical properties of curcumin are extensively examined when it is incorporated into liposome nanoparticles, to enhance its therapeutic potency bioavailability. Curcumin, a plant-derived polyphenol, has garnered attention for anti-inflammatory, antioxidant, anti-cancer activities. However, clinical utility hindered by several limitations, including poor water solubility, inadequate absorption, rapid metabolism. By leveraging potential nanoparticles improve drug delivery efficacy, research aims overcome these obstacles unlock full curcumin. Methods: Curcumin-loaded (CLLNs) were fabricated employing thin-film hydration method, after sonication. The physicochemical attributes CLLNs subsequently characterized, encompassing particle size zeta assessment utilizing dynamic light scattering (DLS), encapsulation efficiency (EE%) loading (DLE%) determination through high-performance liquid chromatography (HPLC), investigation in vitro release patterns simulated biological fluids. Results: optimized study had mean diameter less than 250 nm negative surface charge, implying good stability cellular uptake. both found be high, indicating that was effectively loaded liposomes. testing showed sustained pattern from CLLNs. Conclusion: offered important observations about advantageous features curcumin-loaded highlighting their as cutting-edge system demonstrated have high efficiencies, well controlled improved stability, which suggests ability benefits These findings set stage future vivo trials fully investigate medical applications.

Language: Английский

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