Graphene Oxide Decorated SiO2/Fe3O4 as a Recyclable Catalyst for the Green Synthesis of Novel Thiazinoazepines via Multicomponent Reaction of Isatoic Anhydrides: Cytotoxic Activity and Theoretical Study DOI Open Access
Marziyeh Mohammadi, Zahra Azizi, Zinatossadat Hossaini

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Dec. 10, 2024

ABSTRACT This work investigated the use of a complex technique including isatoic anhydrides, α‐haloketones, electron‐deficient acetylenic compounds, ammonium acetate, and isothiocyanates in water‐based solution at normal room temperature presence SiO 2 /Fe 3 O 4 @Graphene Oxide. The goal was to generate novel thiazinoazepine molecules with significant yields. thiazinoazepines that have been synthesized contain NH functional groups acidic protons demonstrate notable antioxidant activity. (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide), MTT assay utilized evaluate cytotoxicity all compounds vitro against cancer cell lines (MCF‐7 A549) as well lines). Cytotoxicity refers ability compound kill cells. derivative 6e shown be most potent cytotoxic agent, similar doxorubicin its lack selectivity. Alternatively, 6b might considered is equally effective but more selective than doxorubicin. Quantum chemical approaches utilizing density theory enhance comprehension reaction mechanisms. used technology for synthesizing provides several advantages, rapid kinetics, outstanding product yield, straightforward isolation.

Language: Английский

Highly Efficient Ag/Fe3O4@MWCNTs MNCs Catalyzed Green Synthesis of New Derivatives of 1,2,4‐Triazine: The Cytotoxic Activity Investigation of 1,2,4‐Triazines DOI Open Access
Nasir Iravani,

Khatereh Khandan Barani,

Majid Moradian

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 16, 2025

ABSTRACT This study synthesized 1,2,4‐triazines, a novel class of derivatives, with high efficiency using multicomponent reaction. The reaction involved oxoindolinylidene malononitrile, ethyl 2‐arylamino‐4‐dioxo‐4‐arylbutanoates, and hydrazonoyl chlorides in an aqueous solution at room temperature. was facilitated by the presence Ag/Fe 3 O 4 @MWCNTs MNCs. examines antioxidant properties 1,2,4‐triazine addition to other research undertaken this work. Using MTT test, cytotoxic all produced compounds were assessed vitro against cancer cell lines (MCF‐7 A549) normal (BEAS‐2B). It discovered that most effective agent, doxorubicin like its lack selectivity, Derivative 4e . On hand, Compound 4b might be regarded as equipotent molecule greater selectivity relation doxorubicin. production process demonstrated several advantageous features, including rapid reactions, yields final product, straightforward separation catalyst product from mixture.

Language: Английский

Citations

0
A Review of Ionic Liquids: From Solvent Applications to Template‐Assisted Synthesis of Metal Oxide Nanoparticles DOI Open Access

Ashraf Sadat Shahvelayati,

Abolfazl Tanha

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 4, 2025

ABSTRACT Ionic liquids (ILs) have attracted considerable scholarly attention owing to their unique properties and extensive applicability across diverse domains. The exceptional characteristics of ILs present numerous avenues for the conception progression various avant‐garde materials, including highly proficient catalysts. In recent years, a substantial body research has been conducted on synthesis application different categories catalytic materials within chemical reactions. This resulted in topic becoming very captivating worthy study. work presents thorough examination process producing by utilizing as either medium or functional components. Our primary focus is thoroughly researched themes such metal nanocatalysts/IL, IL/support, metals oxides/IL/support, polymeric (PILs) Moreover, we place particular emphasis efficiency these systems.

Language: Английский

Citations

0
Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery DOI

Moumita Ghosh Chowdhury,

Vaishnavi Kalmegh,

Saumya Kapoor

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(5), P. 1488 - 1507

Published: Jan. 1, 2024

The significance of the imidazopyrimidine ring in drug discovery and development lies its versatile applications across various medicinal chemistry domains.

Language: Английский

Citations

3
NiII-containing l-glutamic acid cross-linked chitosan anchored on Fe3O4/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes DOI Creative Commons
Hossein Mousavi, Behzad Zeynizadeh, Morteza Hasanpour Galehban

et al.

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(15), P. 3961 - 3977

Published: Jan. 1, 2024

In this research, new catalytic applications of the Fe 3 O 4 / f -MWCNT-CS-Glu/Ni II nanocomposite have been introduced for efficient reduction and one-pot two-step reductive Schotten–Baumann-type acetylation nitroarenes in water.

Language: Английский

Citations

3
Modified Montmorillonite Catalysed Ultrasonic Assisted one-pot Synthesis of Novel 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones as Potential Anticancer Agents DOI
Samika Anand,

K.R. Sunaja Devi,

Santhosh Govindaraju

et al.

Catalysis Surveys from Asia, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Language: Английский

Citations

1
Green Synthesis of New Coumarins Employing SiO2/Fe3O4@MWCNTs as a Recyclable Catalyst and Evaluation of Antioxidant and Antiproliferative Activity DOI

Mahsa Hojjati,

Fatemeh Sheikholeslami‐Farahani, Ashraf Sadat Shahvelayati

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT This study successfully synthesized coumarins, which belong to a novel class of fused heterocyclic compounds, employing multicomponent reaction with excellent efficiency. The process utilized 4‐aminocumarin or 4‐hydroxycumarin, 2‐arylidenemalononitrile, and activated acetylenic chemicals in an aqueous solution at room temperature the presence MWCNTs@SiO 2 /Fe 3 O 4 as recyclable catalyst. compounds were assessed for their antiproliferative activity against MCF‐7 breast HCT‐15 colon cancer cell lines using sulforhodamine B (SRB) assay, well antioxidant effect. Compounds 4c , 4g 6d exhibited superior compared other compounds. subjected UV‐Vis spectroscopy determine binding affinity DNA BSA. analysis yielded overall constants K 4c‐DNA = 7.9 × 10 M −1 4g‐DNA 1.1 6d‐DNA 4.2 4c‐BSA 4.96 4g‐BSA 7.54 6d‐BSA 6.47 . Our research results could offer fresh data demonstrating correlation between chemical composition ability these coumarin analogs inhibit growth. synthesis coumarins various beneficial characteristics, such fast reactions, high yields end product, easy isolation catalyst product from mixture.

Language: Английский

Citations

1
Green Synthesis and Biological Study of Novel Cyclopenta[b]pyrrolizine: One‐Pot Multicomponent Reactions via Ag/Fe3O4@MWCNTs DOI
Nasir Iravani

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(3)

Published: Nov. 25, 2024

ABSTRACT In this study, the cyclopenta[ b ]pyrrolizine was produced via using a nanocatalyst consisting of Ag/Fe 3 O 4 @MWCNTs in multicomponent reaction that involved 2‐arylidenemalononitrile, ethyl 2‐amino‐4‐dioxo‐4‐arylbutanoates, alkyl bromides, and dimethyl acetylenedicarboxylate. The conducted water at room temperature, resulting synthesis new compounds. synthesized compounds demonstrate antioxidant activity due to occurrence assessment procedures on its OH group. Moreover, an antibacterial efficacy recently pyridines disk diffusion method, employing two distinct strains Gram‐negative bacteria. Notably, tested exhibited inhibitory effects growth Gram‐positive bacteria as well.

Language: Английский

Citations

0
Graphene Oxide Decorated SiO2/Fe3O4 as a Recyclable Catalyst for the Green Synthesis of Novel Thiazinoazepines via Multicomponent Reaction of Isatoic Anhydrides: Cytotoxic Activity and Theoretical Study DOI Open Access
Marziyeh Mohammadi, Zahra Azizi, Zinatossadat Hossaini

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Dec. 10, 2024

ABSTRACT This work investigated the use of a complex technique including isatoic anhydrides, α‐haloketones, electron‐deficient acetylenic compounds, ammonium acetate, and isothiocyanates in water‐based solution at normal room temperature presence SiO 2 /Fe 3 O 4 @Graphene Oxide. The goal was to generate novel thiazinoazepine molecules with significant yields. thiazinoazepines that have been synthesized contain NH functional groups acidic protons demonstrate notable antioxidant activity. (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide), MTT assay utilized evaluate cytotoxicity all compounds vitro against cancer cell lines (MCF‐7 A549) as well lines). Cytotoxicity refers ability compound kill cells. derivative 6e shown be most potent cytotoxic agent, similar doxorubicin its lack selectivity. Alternatively, 6b might considered is equally effective but more selective than doxorubicin. Quantum chemical approaches utilizing density theory enhance comprehension reaction mechanisms. used technology for synthesizing provides several advantages, rapid kinetics, outstanding product yield, straightforward isolation.

Language: Английский

Citations

0