Cited by Synthesis of Some New Barbituric Acid Linked Quinoline-1,2,3-triazole Hybrids as Dual EGFR/VEGFR-2 Inhibitors

Microwave-assisted one-pot synthesis of fused isoxazolo[4′,5′:3,4]pyrrolo[1,2-c]pyrimidines as potent anticancer agents: In vitro and in silico study DOI

Raveendar Reddy Thatikonda,

Karuna Sree Merugu

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: 162, P. 155570 - 155570

Published: April 8, 2025

Language: Английский

Citations

Isoxazole compounds: unveiling the synthetic strategy, In-silico SAR & Toxicity studies and future perspective as PARP inhibitor in cancer therapy DOI

Udita Malik,

Dilipkumar Pal

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116898 - 116898

Published: Sept. 24, 2024

Language: Английский

Citations

Synthesis, anti-microbial evaluation, and in silico studies of novel quinoline-isoxazole hybrids DOI

Deep P. Mandir,

Shivani D. Mandir,

Jignesh H. Kamdar

et al.

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(18), P. 1603 - 1619

Published: Aug. 29, 2024

A series of novel quinoline-isoxazole hybrids 6a–o has been synthesized via multistep synthetic approach involving hetero Diels-alder reaction strategy. The target compounds were obtained in good yield, using low-cost readily available starting materials simple conditions. newly confirmed 1H NMR,13C NMR, and Mass spectroscopic analysis techniques. Further, subjected to vitro antimicrobial screening against various bacterial fungal strains, such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Aspergillus niger, Candida albicans. Among these, 6i, 6j, 6 l found most active having equally potent compared standard drug Ampicillin Gentamycin. Moreover, silico studies with E. coli DNA gyrase through molecular docking MD simulations showed excellent binding properties these derivatives protein site.

Language: Английский

Citations

One-pot synthesis of fused isoxazolo[4′,5′:4,5]thiopyrano[2,3-d]pyrimidines as potent EGFR targeting anti-lung cancer agents DOI

Suresh S. Ardhapure,

Shivraj B. Sirsat

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: unknown, P. 155325 - 155325

Published: Oct. 1, 2024

Language: Английский

Citations

Synthesis of Some New Barbituric Acid Linked Quinoline-1,2,3-triazole Hybrids as Dual EGFR/VEGFR-2 Inhibitors DOI

Annapurna Mamidala,

Narasimha Swamy Thirukovela,

Ashok Kumar Bapuram

et al.

Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(6), P. 1399 - 1411

Published: June 1, 2024

Language: Английский

Citations