Concise Synthesis of Ethericins A and B, C10-Deoxygerfelin, and Diorcinol

Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Naturally occurring diaryl ethers exhibit significant potential for pharmaceutical and agricultural applications owing to their diverse biological activities. Previous synthetic approaches these bioactive molecules have predominantly focused on developing novel aryl–O–aryl bond formation methodologies. In this study, a two-phase strategy is presented, comprising coupling phase establishing the ethereal linkage through SNAr reaction between simple aryl substrates, followed by functionalization enabling precise introduction of substituents C–H activation subsequent cross-coupling transformations. This modular approach has enabled efficient synthesis four natural products: ethericin A, B, C10-deoxygerfelin, diorcinol.

Language: Английский

Mechanistic and thermodynamic studies on directing group-assisted copper-catalyzed α-C(sp2)−H amination of aryl amines with alkylamines

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123400 - 123400

Published: Sept. 1, 2024

Language: Английский

Ruthenium-catalyzed synthesis of novel phenoxy(phenyl)-1H-benzo[d]imidazoles: Spectral characterization and DFT studies

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140834 - 140834

Published: Nov. 1, 2024

Language: Английский