Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 6047 - 6047
Published: Dec. 22, 2024
Benzylic
C–H
oxidation
to
form
carbonyl
compounds,
such
as
ketones,
is
a
fundamental
transformation
in
organic
synthesis
it
allows
for
the
preparation
of
versatile
intermediates.
In
this
review,
we
highlight
aromatic
ketones
via
catalytic,
electrochemical,
and
photochemical
alkylarenes
using
different
catalysts
oxidants
past
5
years.
Additionally,
also
discuss
heterocyclic
molecules
benzylic
key
step.
These
methods
can
potentially
be
used
medicinal,
synthetic,
inorganic
chemistry.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Jan. 1, 2025
Abstract
An
electrochemical
cyclization
strategy
is
employed
herewith
for
the
eco‐friendly
and
cost‐effective
synthesis
of
2‐substituted
quinazolines
by
using
2‐aminobenzylamines
aldehydes
or
alcohols
as
starting
substrates.
The
reactions
were
conducted
under
two
distinct
reaction
temperatures:
25
°C
60
alcohols.
Tetra‐
n
‐butylammonium
iodide
(TBAI)
participates
in
dual
roles
such
as,
an
electrolyte
a
mild
reagent
to
facilitate
formation
at
constant
current
30
mA
graphite
electrode
anode
platinum
cathode
dimethyl
sulfoxide
(DMSO)
solvent.
Under
devised
process,
accomplished
with
broad
substrate
scope
excellent
yields
(up
90%),
which
reduces
toxic
side
products.
plausible
mechanistic
pathways
have
been
formulated,
are
supported
control
experiments
cyclic
voltammetry
studies.
findings
demonstrate
that
conditions,
iodonium
ions
generated,
play
crucial
role
enhancing
efficacy
described
method.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
A
cost-effective,
eco-friendly,
and
highly
efficient
one-pot
electrochemical
process
has
been
described
for
the
synthesis
of
4H-1,3-benzoxazine
4,5-dihydro-1,3-benzoxazepine
derivatives
by
employing
2-aminobenzyl
alcohols,
2-(2-aminophenyl)ethan-1-ol,
isothiocyanate
derivatives,
TBAPF6
as
an
electrolyte.
The
developed
method
is
accomplished
at
25
°C
with
a
constant
current
20
mA.
Utilizing
graphite
anode
platinum
cathode
in
dimethyl
sulfoxide
solvent,
devised
metal-free
approach
minimizes
production
waste
eliminates
need
external
oxidizing
agents.
Furthermore,
these
valuable
molecules
significantly
enhances
ongoing
trends
synthetic
organic
chemistry.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(24), P. 3793 - 3814
Published: Aug. 20, 2024
Abstract
Considering
the
importance
of
heterocycles,
significantly
represented
in
medicinal
chemistry
and
drug
development,
single-atom
insertion
technique
transmutation
strategy
provide
productive
approaches
towards
complicated
molecular
structures
through
heterocycle
diversification.
It
shows
a
potentially
powerful
approach
for
modifying
complex
substrates
concisely
chemospecifically.
Although
skeletal
editing
applies
to
cyclic
acyclic
compounds,
this
review
focuses
on
diversification
carbo-
heterocyclic
compounds
synthesizing
various
medicinally
important
molecules
via
technique.
The
classification
system
is
based
recent
critical
historical
methods
as
applied
aromatic
rings.
1
Introduction
2
Skeletal
Editing
Carbon-Atom
Insertion
2.1
Indoles
Pyrroles
Derivatives:
into
C=C
Bond
2.2
Pyrazole
Indazole
an
N–N
2.3
CF3
Group
Heteroarenes
2.4
Imidazole
C–N
2.5
Atom-to-Atom
Transmutation
3
N-Atom
3.1
Nitrogen-Atom
Carbocycles
3.2
Heterocycles
3.3
Carbon
Nitrogen
Molecular
Isotopic
4
Conclusion
Energy & Fuels,
Journal Year:
2024,
Volume and Issue:
38(10), P. 8481 - 8515
Published: April 24, 2024
CO2
is
an
important
component
of
the
atmosphere
that
helps
in
balancing
Earth's
atmospheric
temperature
and
channelizes
food
cycles.
However,
increase
or
decrease
concentration
will
severely
affect
climate.
Particularly,
rise
levels
has
immensely
contributed
to
global
warming,
resulting
elevated
temperature,
altered
precipitation
patterns,
glacier
melting,
subsequent
rises
sea
levels,
impacting
human
well-being.
In
response,
researchers
are
exploring
strategies
capture
convert
into
valuable
products,
such
as
methanol,
formic
acid,
organic
compounds.
synthesis
compounds
using
CO2,
like
benzimidazole
quinazolines,
a
high
impact.
Benzimidazole,
widely
used
medicinal
chemistry
for
treating
cancer
stomach
ulcers,
also
exhibits
antiviral
antifungal
properties.
Quinazoline
derivatives,
essential
drugs
prazosin
doxazosin,
have
applications
post-traumatic
stress
disorder
Alzheimer's
disease.
These
were
synthesized
mainly
environmentally
harmful
synthons
phosgene
potassium
cyanide.
To
address
both
environmental
health
concerns,
delving
chemical
fixation
sustainable
green
production.
Catalysis
emerges
key
principle
chemistry,
with
catalysts
reducing
activation
energy
facilitating
processes.
This
review
discusses
recent
state
art
on
development
various
conversion
quinazoline
benzimidazole,
through
homogeneous
heterogeneous
catalysts.
Notably,
while
lack
industrial
recyclability,
show
promise
large-scale
implementation.
comprehensive
mechanistic
aspects
DFT
studies
understanding
better.
Toward
end,
it
gives
future
scope
this
subject.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 22, 2024
Abstract
This
review
highlights
the
multifaceted
usefulness
of
o-halobenzyl
halides
as
pivotal
substrates
for
construction
five-
to
nine-membered
cyclic
structures
with
aid
transition
metals
catalysts.
These
privileged
entities
engage
dual
active
sites,
enabling
combination
both
intermolecular
benzylation
and
intramolecular
arylation
strategies
that
directs
formation
a
diverse
repository
structures.
The
introduction
transition-metal
catalysis
in
cross-coupling
transformations
sparked
revolution
forging
aryl–heteroatom
bonds,
culminating
evolution
more
potent
methodologies
synthesis
wide
spectrum
valuable
compounds.
Furthermore,
associated
pharmaceutical
biological
attributes
these
augment
their
significance
medicinal
chemistry
research.
aims
showcase
importance
this
synthetic
methodology
its
far-reaching
applications
synthesis.
1
Introduction
2
Synthesis
Five-Membered
Rings
3
Six-Membered
4
Seven-Membered
5
Eight-
Nine-Membered
6
Conclusion
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
13(8)
Published: June 4, 2024
Abstract
A
straightforward
strategy
for
the
synthesis
of
pharmaceutically
active
2‐aminobenzoxazoles
and
2‐aminobenzothiazoles
is
described
by
using
2‐aminophenols,
2‐aminothiophenols,
functionalized
phenylisothiocyanates
as
model
substrates.
The
developed
method
proceeds
through
HFIP‐promoted
cyclodesulfurization
process
which
allows
efficient
these
scaffolds
at
60
°C
reaction
temperature
without
addition
a
transition
metal‐catalyst
or
hazardous
solvents
with
excellent
yields
(up
to
92
%)
product
formation.
This
involves
HFIP‐mediated
hydrogen
bonding
interactions
hydroxyl
thiol
moieties,
leading
bond
breaking
formation
during
reaction,
resulting
in
compounds
interest
situ
release
H
2
S
gas.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(4)
Published: Jan. 1, 2025
Abstract
Oxazoles
are
key
heterocyclic
motifs
in
pharmaceuticals
and
natural
products.
We
report
a
base‐promoted
method
for
the
synthesis
of
oxazoles
from
acyl
cyanides
isocyanates
under
mild
conditions.
Using
KOH
as
catalyst
acetonitrile
at
80
°C,
variety
with
different
substituents
were
cyclized
efficiently,
yielding
good
to
excellent
yields
(up
98%).
A
plausible
mechanism
involving
1,1‐addition,
1,3‐H
shift,
intramolecular
cyclization
is
proposed.
This
work
offers
straightforward
versatile
approach
oxazole
synthesis.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(11), P. 6625 - 6633
Published: Jan. 1, 2024
The
use
of
large
amounts
a
homogeneous
electrolyte
represents
major
sustainability
issue
in
electrosynthesis.
Herein,
we
report
the
solid
and
reusable
with
excellent
performance
representative
electrosynthesis
2-arylbenzoxazoles.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 30, 2024
Abstract
1,2,3,4-Tetrahydroquinolines
(THQs)
are
present
in
molecules
with
significant
biological
importance
and
pharmaceuticals
diverse
activities.
Various
synthetic
routes
have
been
developed
to
tetrahydroquinolines,
such
as
the
hydrogenation
of
quinolines,
domino
reactions,
intramolecular
cyclization,
notably,
Povarov
reaction.
Organocatalysts
small,
chiral
organic
that
can
successfully
catalyze
transformations.
This
review
examines
use
organocatalysts
asymmetric
synthesis
tetrahydroquinoline
derivatives
using
aminocatalysis,
NHC
catalysis,
H-bonding
catalysis
covering
literature
between
2000
early
2024.
1
Introduction
2
Aminocatalysis
3
Catalysis
4
H-Bonding
5
Miscellaneous
6
Conclusion