Direct Synthesis of 2-Functionalized 3-Nitroindoles from Diazo(nitro)acetanilides DOI

Qingchun Meng,

Xuan Ke, Jiaxi Xu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 90(2), P. 1186 - 1195

Published: Jan. 7, 2025

2-Hydroxyl/acetoxy-3-nitroindoles are directly and efficiently prepared in good to excellent yields from diazo(nitro)acetanilides under the catalysis of Cu(MeCN)4PF6 DCM through an intramolecular aromatic C-H insertion or followed by acetylation. 2-Hydroxyl-3-nitroindoles can be further transformed 3-halo-3-nitroindolin-2-ones 3-alkanamidoindolin-2-ones readily. All them important synthetic building blocks for construction indole derivatives.

Language: Английский

Direct Synthesis of 2-Functionalized 3-Nitroindoles from Diazo(nitro)acetanilides DOI

Qingchun Meng,

Xuan Ke, Jiaxi Xu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 90(2), P. 1186 - 1195

Published: Jan. 7, 2025

2-Hydroxyl/acetoxy-3-nitroindoles are directly and efficiently prepared in good to excellent yields from diazo(nitro)acetanilides under the catalysis of Cu(MeCN)4PF6 DCM through an intramolecular aromatic C-H insertion or followed by acetylation. 2-Hydroxyl-3-nitroindoles can be further transformed 3-halo-3-nitroindolin-2-ones 3-alkanamidoindolin-2-ones readily. All them important synthetic building blocks for construction indole derivatives.

Language: Английский

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