Acceptorless dehydrogenation under neat reaction conditions: Synthesis of 2-aryl/alkyl quinazolinones using supported Ni NPs as catalyst DOI

M. Vageesh,

Omkar Patil,

Raju Dey

et al.

Synlett, Journal Year: 2024, Volume and Issue: 35(20), P. 2496 - 2502

Published: Aug. 15, 2024

Abstract We report here a Ni-NPs-catalyzed one-pot synthesis of 2-alkyl/aryl quinazolinone motifs via acceptorless dehydrogenation alcohol, condensation an aldehyde intermediate with 2-aminobenzamide, followed by second the cyclized intermediate. The protocol is atom-economical and require earth-abundant Ni as catalyst. present involves annulation 2-aminobenzamide various types primary alcohols, including aryl/heteroaryl methanol, aliphatic produces high yields desired products under neat conditions. catalyst was synthesized high-temperature pyrolysis strategy, using ZIF-8 sacrificial template. NPs@N-C characterized XPS, HR-TEM, HAADF-STEM, XRD, ICP-MS. stable even in air at room temperature displayed excellent activity dehydrogenative coupling quinazolinones could be recycled five times without appreciable loss its activity.

Language: Английский

Acceptorless dehydrogenation under neat reaction conditions: Synthesis of 2-aryl/alkyl quinazolinones using supported Ni NPs as catalyst DOI

M. Vageesh,

Omkar Patil,

Raju Dey

et al.

Synlett, Journal Year: 2024, Volume and Issue: 35(20), P. 2496 - 2502

Published: Aug. 15, 2024

Abstract We report here a Ni-NPs-catalyzed one-pot synthesis of 2-alkyl/aryl quinazolinone motifs via acceptorless dehydrogenation alcohol, condensation an aldehyde intermediate with 2-aminobenzamide, followed by second the cyclized intermediate. The protocol is atom-economical and require earth-abundant Ni as catalyst. present involves annulation 2-aminobenzamide various types primary alcohols, including aryl/heteroaryl methanol, aliphatic produces high yields desired products under neat conditions. catalyst was synthesized high-temperature pyrolysis strategy, using ZIF-8 sacrificial template. NPs@N-C characterized XPS, HR-TEM, HAADF-STEM, XRD, ICP-MS. stable even in air at room temperature displayed excellent activity dehydrogenative coupling quinazolinones could be recycled five times without appreciable loss its activity.

Language: Английский

Citations

1