The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
We herein report a multicomponent reaction for the synthesis of
Language: Английский
Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1594 - 1594
Published: April 2, 2025
A concerted five-component reaction strategy has been developed, featuring double [3+2] cycloadditions utilizing aspartic acid. This approach provides valuable insights into mechanistic pathways, allowing for the distinction between and stepwise processes based on efficiency diastereoselectivity. Both glutamic acids have employed a thorough evaluation exploration of decarboxylation-driven annulations. method effectively constructs pyrrolizidine frameworks through 1,3-dipolar cycloaddition with acid, as well tetrahydropyrrolizinones via three-component annulations, which include decarboxylative lactamization These highly convergent, multicomponent reactions (MCRs) efficiently produce fused polyheterocyclic systems while being environmentally friendly, generating only CO2 water byproducts.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 18, 2025
The 1,2,3-triazole scaffolds are an important class of biologically privileged heterocyclic compounds with several key applications in chemistry, biology, medicine, agriculture, and material science. "postclick" functionalization 1,2,3-triazoles may emerge as a promising tactic for the construction molecular architectures therapeutics is considered to be growing area investigation. This interest extends beyond regioselective Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) method that involves trapping Cu(I)-triazole suitable precursors. In this Perspective, we highlight impact postclick strategies organic synthesis required late-stage hope emerging concept provide ample opportunities modern notable medicinal materials
Language: Английский
Citations
0
ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)
Published: Nov. 1, 2024
Abstract Synthetic chemists have organized easy and effective ways to achieve perfect synthesis in response the requirement for scaffolds that are crucial medical applications. A general strategy was developed of fused [1,2,3]triazolo[4′,5′:3,4]pyrrolo[1,2‐c]pyrimidines using one‐pot CuI‐catalyzed cycloaddition followed by C─C bong coupling. The cancer activity synthesized compounds then tested vitro against two lung cell lines some showed potent compared primary standard, 5‐FU. We also found EGFR properties results 1‐(3,5‐difluorophenyl)‐7‐methyl‐1,4‐dihydro‐6H‐[1,2,3]triazolo[4′,5′:3,4]pyrrolo[1,2‐c]pyrimidine‐6,8(7H)‐dione, 1‐(3,5‐dichlorophenyl)‐7‐methyl‐1,4‐dihydro‐6H‐[1,2,3]triazolo[4′,5′:3,4]pyrrolo[1,2‐c]pyrimidine‐6,8(7H)‐dione were strong inhibitors remaining compounds. carried out silico studies assess molecular interactions more with proteins (PDB: 4HJO). Our findings revealed all exhibited binding than standard erlotinib (‐7.69 K cal/mol) energies from −8.22 −9.45 cal/mol.
Language: Английский
Citations
1
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(45), P. 5824 - 5827
Published: Jan. 1, 2024
A facile synthesis of multi(triazole)s by iterative click reactions is disclosed. Diverse multi(triazole)-type mid-molecules can be synthesized easily from readily available modules through good chemoselective reactions.
Language: Английский
Citations
0
Materials horizons, Journal Year: 2024, Volume and Issue: unknown, P. 559 - 601
Published: Jan. 1, 2024
Language: Английский
Citations
0
RSC Advances, Journal Year: 2024, Volume and Issue: 14(42), P. 30873 - 30885
Published: Jan. 1, 2024
A novel series of poly(1,2,3-triazolyl)-substituted perhalopyridines were synthesized under ultrasonic irradiation. We also developed an effective method for the preparation ((1,2,3-triazol-4-yl)methoxy)-3,4,5,6-tetrachloropyridines.
Language: Английский
Citations
0
ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(38)
Published: Oct. 1, 2024
Abstract A new series of Coumarin‐tethered‐1,2,3‐triazoles ( 7a–i and 9a–f ) were synthesized by the copper‐assisted 1,3‐dipolar cycloaddition reaction coumarin alkyne 5 with variedly substituted azides 6a–I 8a–f ). All compounds spectroscopically characterized in vitro antimicrobial testing against a panel bacterial fungal strains was systematically carried out. The bearing 3‐Cl 7b 2‐NO 2 7i substituents which emerged as most potent showed noticeable activity Staphylococcus aureus . Additionally, density functional theory (DFT) calculations conducted to explore chemical reactivity stability parameters compounds.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
We herein report a multicomponent reaction for the synthesis of
Language: Английский
Citations
0