An Overview on the Role of Ionic Liquids and Deep Eutectic Solvents in Oral Pharmaceuticals
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 300 - 300
Published: Feb. 25, 2025
Over
the
past
twenty
years,
ionic
liquids
(ILs)
and
deep
eutectic
solvents
(DESs)
have
gained
recognition
across
various
fields,
including
catalysis,
extraction
purification,
materials
science,
biotechnology.
Notably,
use
of
ILs
DESs
in
pharmaceutical
research,
especially
drug
delivery,
has
seen
remarkable
expansion
over
decade.
This
review
offers
a
comprehensive
analysis
specifically
designed
for
oral
administration
drugs
having
unfavorable
biopharmaceutical
properties.
The
classification
characteristics
DESs,
along
with
their
newer
natural
(Bio-ILs
NaDESs)
therapeutic
subcategories
(API-ILs
TheDESs)
are
outlined.
Additionally,
further
subgroup
ILs,
known
as
surface
active
(SAILs),
is
described.
Then,
detailed
examination
available
manufacturing
methods
sustainable,
time-consuming,
scalable
perspective,
toxicity
concerns
relation
to
subdivision
evaluated.
Finally,
specific
applications
whether
used
neat
or
converted
into
administrable
dosage
forms,
analyzed
discussed.
Despite
significant
advancements
recent
years
regarding
these
there
still
many
aspects
that
need
investigation.
These
include
interaction
biological
systems
(gastrointestinal
fluids
mucosa),
long-term
stability,
development
effective
delivery
systems.
Language: Английский
Optimized extraction and characterization of ramie leaf polysaccharides using deep eutectic solvent and microwave: Antioxidant, metal chelation, and UV protection properties
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
unknown, P. 136927 - 136927
Published: Oct. 1, 2024
Language: Английский