The enzyme kinetic studies, DNA protection and antioxidant activities of furan/ thiophene-2-carboxamide derivatives DOI Open Access
Şükriye Çakmak, Semiha Yenigün, Tevfik Özen

et al.

International Journal of Chemistry and Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Three furan and/or thiophene-2-carboxamide compounds, namely N-(furan-2-ylmethyl)thiophene-2-carboxamide (1), N-(furan-2-carbonyl)furan-2-carboxamide (2), and N-(Thiophene-2-ylmethyl)furan-2-carboxamide (3) were investigated the enzyme kinetic studies by urease, acetylcholinesterase (AChE), butyrylcholinesterase (BChE). The inhibition constant (Ki) of Compound (CPD)3 AChE was determined as 0.10 mM, Ki value BChE 0.07 mM. In comparison, CPD1 urease These CPDs examined for antioxidant activity DPPH˙ scavenging method. CPD3 exhibited 98.93% DPPH compared to ascorbic acid, positive control group. Furthermore, DNA-protective activities compounds investigated, DNA protection observed be 78%. findings suggest that thiophene/furan carboxy amide-containing might exploited potential structures evaluating pharmaceuticals with greater potency.

Language: Английский

Untargeted metabolomics approach based on UPLC-ESI-QTOF-MS/MS and evaluation of Antioxidant and Cytotoxic Activities of Nepeta deflersiana Schweinf. ex Hedge Supported by Molecular Modeling and ADMET Analysis DOI

Ines El Mannoubi,

Mozaniel Santana de Oliveira,

Seham Hassan Bashir

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1333, P. 141767 - 141767

Published: Feb. 15, 2025

Language: Английский

Citations

1
The enzyme kinetic studies, DNA protection and antioxidant activities of furan/ thiophene-2-carboxamide derivatives DOI Open Access
Şükriye Çakmak, Semiha Yenigün, Tevfik Özen

et al.

International Journal of Chemistry and Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Three furan and/or thiophene-2-carboxamide compounds, namely N-(furan-2-ylmethyl)thiophene-2-carboxamide (1), N-(furan-2-carbonyl)furan-2-carboxamide (2), and N-(Thiophene-2-ylmethyl)furan-2-carboxamide (3) were investigated the enzyme kinetic studies by urease, acetylcholinesterase (AChE), butyrylcholinesterase (BChE). The inhibition constant (Ki) of Compound (CPD)3 AChE was determined as 0.10 mM, Ki value BChE 0.07 mM. In comparison, CPD1 urease These CPDs examined for antioxidant activity DPPH˙ scavenging method. CPD3 exhibited 98.93% DPPH compared to ascorbic acid, positive control group. Furthermore, DNA-protective activities compounds investigated, DNA protection observed be 78%. findings suggest that thiophene/furan carboxy amide-containing might exploited potential structures evaluating pharmaceuticals with greater potency.

Language: Английский

Citations

0