Investigating the Antimicrobial, Antidiabetes, and Antioxidant Potential of Hydroxyl‐Containing Schiff Bases, In Vitro, and Computational Studies DOI
Adesola A. Adeleke, Segun D. Oladipo, Robert C. Luckay

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(7)

Published: Feb. 1, 2025

Abstract Four azomethine compounds ( L 1 –L 4 ) derived from the reaction of p ‐hydroxybenzaldehyde and various primary amines are reported herein. Various analytical spectroscopic techniques were employed to characterize synthesized compounds. The antidiabetic properties evaluated by exploring α‐amylase α‐glucosidase assays, where 2 3 displayed good with an IC 50 values 0.06 0.03 mg/ml for assay, respectively, better than acarbose (standard drug) value 0.08 mg/ml. With exception L4, antioxidant activity showed nitric oxide radical scavenging capacity their significant DPPH free ability. antibacterial activities dose‐dependent, notable activities. Computational studies using density functional theory molecular docking methods indicated that had energy gap 7.10 eV, making it least reactive, while 6.52 most chemically reactive.

Language: Английский

Investigating the Antimicrobial, Antidiabetes, and Antioxidant Potential of Hydroxyl‐Containing Schiff Bases, In Vitro, and Computational Studies DOI
Adesola A. Adeleke, Segun D. Oladipo, Robert C. Luckay

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(7)

Published: Feb. 1, 2025

Abstract Four azomethine compounds ( L 1 –L 4 ) derived from the reaction of p ‐hydroxybenzaldehyde and various primary amines are reported herein. Various analytical spectroscopic techniques were employed to characterize synthesized compounds. The antidiabetic properties evaluated by exploring α‐amylase α‐glucosidase assays, where 2 3 displayed good with an IC 50 values 0.06 0.03 mg/ml for assay, respectively, better than acarbose (standard drug) value 0.08 mg/ml. With exception L4, antioxidant activity showed nitric oxide radical scavenging capacity their significant DPPH free ability. antibacterial activities dose‐dependent, notable activities. Computational studies using density functional theory molecular docking methods indicated that had energy gap 7.10 eV, making it least reactive, while 6.52 most chemically reactive.

Language: Английский

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